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Full-Text Articles in Biological Psychology
Serotonin 1b/1a Receptor Modulation On Behavioral Flexibility In C57bl/6j Mice, Brandon L. Oliver
Serotonin 1b/1a Receptor Modulation On Behavioral Flexibility In C57bl/6j Mice, Brandon L. Oliver
Electronic Theses, Projects, and Dissertations
Pharmacological activation of the 5-HT1B and 1A receptors has been implicated in OCD-like behaviors in rodents such as increased perseverative circling, checking behaviors, and locomotor stereotypy. However, little is understood about the effects of 5-HT1B and 1A receptor activation on behavioral inflexibility, a common symptom associated with OCD. The present study utilized the 5-HT1B/1A receptor agonist RU24969 at 0.01, 0.1, and 1.0 mg/kg to test three hypotheses. The first hypothesis predicted RU24969 would lead to a dose-dependent impairment on behavioral flexibility in C57BL/6J mice. It was also predicted that male C57BL/6J mice would be more inflexible than female C57BL/6J mice …
Circuits Underlying Serotonin Mediated Sex Differences In Fear Learning, Rebecca Ravenelle
Circuits Underlying Serotonin Mediated Sex Differences In Fear Learning, Rebecca Ravenelle
Dissertations, Theses, and Capstone Projects
Post-traumatic stress disorder (PTSD) is a trauma-related disorder characterized by intense fearful memory formation. Women are twice as likely as men to develop PTSD, indicating there may be sex differences in the underlying neural circuits. Given that serotonin (5-HT) dysfunction is implicated in PTSD, and 5-HT modulates fear learning, we investigated whether there are sex differences in the modulation of fear learning by 5-HT. We administered the selective serotonin reuptake inhibitor (SSRI) citalopram (20mg/kg or 10m/kg, i.p.) once to male and female mice prior to auditory fear conditioning and tested the effects on fear memory the next day. We found …