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Full-Text Articles in Biological Psychology
Effects Of Early Amphetamine Exposure On Memory, Wendy Ann Holmquist
Effects Of Early Amphetamine Exposure On Memory, Wendy Ann Holmquist
Theses Digitization Project
The purpose of the current study was to determine if rat pups treated with amphetamine (AMPH) during a critical time of hippocamal development would exhibit deficits in spatial learning and memory when tested in the Morris water maze during adolescence. Exposure to amphetamine during early postnatal development induces long-term reductions in protein kinase A (PKA) activity. Because PKA activity is known to regulate the production of brain derived neurotrophic factor (BDNF), and reductions in BDNF are associated with memory deficits, it was hypothesized that early exposure to amphetamine would lead to declines in both BDNF levels and memory performance. The …