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Full-Text Articles in Biological Psychology
The Effect Of Early Psychostimulant Treatment On Abuse Liability And Dopamine Receptors, Steven Wayne Villafranca
The Effect Of Early Psychostimulant Treatment On Abuse Liability And Dopamine Receptors, Steven Wayne Villafranca
Theses Digitization Project
Examines whether the reinforcing properties of drugs of abuse were altered in adulthood by methylphenidate, more commonly known as Ritalin. Subjects were 108 rats of Sprague-Dawley descent (Harlan). Methylphenidate, or saline was administered daily to the subjects from the postnatal period (11-20 days old). The rats preference for morphine during early adulthood was measured using conditioned place preference. The number of dopamine D₂ receptors was measured in each rat and the correlation between receptor number and morphine preference was determined. Results indicate that rats pretreated with methylphenidate showed greater preference for morphine than saline pretreated rats and suggests that exposure …
Effect Of Preweanling Methylphenidate Exposure On The Induction, Extinction And Reinstatement Of Morphine-Induced Conditioned Place Preference In Rats, Kellie Lynn Kucher
Effect Of Preweanling Methylphenidate Exposure On The Induction, Extinction And Reinstatement Of Morphine-Induced Conditioned Place Preference In Rats, Kellie Lynn Kucher
Theses Digitization Project
This study examined the effect of preweanling methyphenidate exposure on later drug reward. We examined the induction, extinction, and reinstatement of morphine induced conditioned place preference (CPP) in rats that received methylphenidate pretreatment during the preweanling period.