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Full-Text Articles in Biological Psychology
249— The Role Of The Indirect Basal Ganglia Pathway In A Mouse Model Of Repetitive Circling Behavior, Gavin Vaughan, Allison R. Bechard
249— The Role Of The Indirect Basal Ganglia Pathway In A Mouse Model Of Repetitive Circling Behavior, Gavin Vaughan, Allison R. Bechard
GREAT Day Posters
Repetitive behaviors are associated with a variety of disorders in humans and are diagnostic for autism spectrum disorders. Repetitive behaviors can be modeled in rodents. In our previous experiments, we have been able to reduce repetitive circling behaviors in mice using a ketogenic diet. The mechanisms behind the ketogenic diet are still under investigation. Previous investigations have indicated that the ketogenic diet plays a role in neurotransmitter functioning. This study sought to investigate the potential role of neurotransmitters in repetitive behaviors by investigating how three drugs (L-741,626, a dopamine receptor antagonist; CGS21680, an adenosine agonist; & CDPPB, a glutamate positive …
258— Differential Response To Cocaine In Mice Exposed To Stress, Gavin Vaughan, Melissa Herman, Isabel Ross, Katie Bugbee, April Rowell, Jennifer Bodzon, Allison R. Bechard Ph.D.
258— Differential Response To Cocaine In Mice Exposed To Stress, Gavin Vaughan, Melissa Herman, Isabel Ross, Katie Bugbee, April Rowell, Jennifer Bodzon, Allison R. Bechard Ph.D.
GREAT Day Posters
Exposure to trauma is a risk factor for substance use disorders. Using a mouse model of PTSD, we tested the effects of exposure to a stressor (synthetic fox pheromone: TMT) on response to cocaine. Cocaine induced locomotion and cocaine seeking behavior in a conditioned place preference (CPP) were assessed. TMT was an effective stressor, indicated by freezing behavior, which is a known fear response in mice. In both males and females, TMT-exposed mice showed a greater locomotor response to cocaine compared to control mice, resulting in the interaction between time and TMT treatment. TMT-exposed males, but not females, were overall …