Biological Psychology Commons^™

The Effect Of Early Life Stress On Methamphetamine Damage In The Striatum, Emily Hensleigh

UNLV Theses, Dissertations, Professional Papers, and Capstones

Methamphetamine (METH) abuse impacts the global economy through costs associated with drug enforcement, emergency room visits, and treatment. Hyperthermia is a leading cause of METH induced emergency room visits and may lead to neural damage. Previous research has demonstrated early life stress, such as childhood abuse, increases the likelihood of developing a substance abuse disorder. However, the effects of early life stress on neuronal damage induced by chronic METH administration are unknown. We aimed to elucidate the effects of early life stress on METH induced dopamine damage in the striatum. Animals were separated three hours per day during the first …