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Full-Text Articles in Biological Psychology
The Role Of The Progesterone Receptor In The Development Of The Ventromedial Nucleus And Female Sexual Behaviors, Keith L. Gonzales
The Role Of The Progesterone Receptor In The Development Of The Ventromedial Nucleus And Female Sexual Behaviors, Keith L. Gonzales
Legacy Theses & Dissertations (2009 - 2024)
Steroid induced gene transcription plays an important role in neural sex differences within many mammalian species. Steroid hormones actions within the developing brain have profound, permanent effects in the development of neurochemical processes and behaviors. Within the developing ventromedial nucleus of the hypothalamus (VMN), a potent transcription factor, the progesterone receptor (PR), is highly expressed within female rats. Furthermore, the regulation of PR within the developing VMN of the female rat is anatomically and developmentally specific. Typically, PR expression is highly dependent on the activity of estradiol acting at ERα. As such, circulating levels of estradiol act to induce PR …
The Effects, Brain Targets, And Mechanisms Of Estradiol For Affective Behavior, Alicia Ann Walf
The Effects, Brain Targets, And Mechanisms Of Estradiol For Affective Behavior, Alicia Ann Walf
Legacy Theses & Dissertations (2009 - 2024)
Although estradiol (E2) has numerous effects in the central nervous system, this review will focus on addressing the effects of E2 on behaviors related to mood in women and animal models and include recent findings from our laboratory related to this topic. E2's anti-anxiety and anti-depressant-like effects may depend upon many factors (e.g. age, reproductive history/status, time in E2 deficient state before initiation of E2 therapy, regimen and dosing of E2, neuropsychiatric/stress history). First, evidence of how factors may alter responses to E2 in people and in animal models will be discussed. Second, interactions of E2 with the hypothalamic-pituitary-adrenal axis/stress …