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Full-Text Articles in Biological Psychology
The Role Of Glucose Transporter 4 During Cognitive Enhancement By Angiotensin Iv, Leslie Ann Sandusky
The Role Of Glucose Transporter 4 During Cognitive Enhancement By Angiotensin Iv, Leslie Ann Sandusky
Legacy Theses & Dissertations (2009 - 2024)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized behaviorally by profound cognitive impairment. Currently, there is no cure for this disorder and available therapeutics only slow the progression of cognitive decline in a subset of the AD population Recent research has shifted to upregulation of the insulin signaling pathway as a mechanism to restore cognition in the AD population, as this system is known to be impaired in the AD brain. A possible novel therapeutic for the treatment of cognitive impairment is Angiotensin IV (Ang IV). Ang IV is an endogenous pentapeptide inhibitor of the insulin-regulated aminopeptidase (IRAP) and …