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Full-Text Articles in Biological Psychology
The Role Of Glucose Transporter 4 During Cognitive Enhancement By Angiotensin Iv, Leslie Ann Sandusky
The Role Of Glucose Transporter 4 During Cognitive Enhancement By Angiotensin Iv, Leslie Ann Sandusky
Legacy Theses & Dissertations (2009 - 2024)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized behaviorally by profound cognitive impairment. Currently, there is no cure for this disorder and available therapeutics only slow the progression of cognitive decline in a subset of the AD population Recent research has shifted to upregulation of the insulin signaling pathway as a mechanism to restore cognition in the AD population, as this system is known to be impaired in the AD brain. A possible novel therapeutic for the treatment of cognitive impairment is Angiotensin IV (Ang IV). Ang IV is an endogenous pentapeptide inhibitor of the insulin-regulated aminopeptidase (IRAP) and …
The Role Of Igf-Ii In Memory Enhancement : Implications For Autism Spectrum Disorders, Amy S. Kohtz
The Role Of Igf-Ii In Memory Enhancement : Implications For Autism Spectrum Disorders, Amy S. Kohtz
Legacy Theses & Dissertations (2009 - 2024)
Cognitive and memory impairments significantly affect multiple domains in life and play major roles in disease. Identifying critical mechanisms and factors that mediate memory consolidation and enhancement may represent an important approach for increasing cognition in normal adults and preventing or treating cognitive impairments. The expression of the C/EBP- target gene insulin-like growth factor 2, (IGF-II) is required for memory consolidation; furthermore, IGF-II administration during memory consolidation produces memory enhancement, increased memory persistence and prevents forgetting. In this thesis, I investigated the therapeutic potential of IGF-II to promote memory consolidation when administered systemically. In addition, I investigated one particularly interesting …