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Genetic And Ontogenetic Variation In Response To Scopolamine And D-Amphetamine In Three Strains Of Mice, Gary Remington

Theses and Dissertations (Comprehensive)

Highly inbred mice of three strains (A/J, DBA/2J and C57BL/6J) were tested in an acitivity task at 14, 21, or 28 days of age. Ten minutes prior to testing, mice received treatment of either saline, scopolamine (0.1 or 1.0 mg/kg) or d-amphetamine (0.5, 1.0 or 5.0 mg/kg). At 14 days of age DBA mice exhibited higher levels of activity than either A or C57 mice. However, the increase in activity in C57 was such that at 21 and 28 days no difference was observed relative to DBA mice, and activity was higher than that of A mice. With respect to …