Biological Psychology Commons^™

Preclinical Behavioral Assessment Of Chronic, Intermittent Low-Dose Psilocybin In Rodent Models Of Depression And Anxiety, Harmony I. Risca

Dissertations

Recent studies have demonstrated the clinical efficacy of psychedelic-assisted psychotherapy for treatment-resistant depression and anxiety. Amidst the overall success of recent clinical trials using a single high dose of psilocybin, anecdotal reports indicate anxiolytic and antidepressant effects following a repeated low dose regimen. As therapeutic outcomes are often tightly intertwined with the individual’s subjective experience, animal models are used as objective measures to investigate the underlying mechanisms responsible for the putative antidepressant/anxiolytic effects of psychedelics. Three rodent models predictive of anxiolytic or antidepressant effects were used to evaluate effects of chronic intermittent low dose (CILD) psilocybin treatment; the Light/Dark conflict …

Assessment Of Dopaminergic And Serotonergic Receptor Antagonists In Male Rats Trained To Discriminate 4-Methylmethcathinone (Mephedrone), Rachel L. Burroughs

Masters Theses

Preclinical drug discrimination studies of the synthetic cathinone, 4-methylmethcathinone (mephedrone) have demonstrated its effects are comparable to those of other popular psychostimulant drugs. Few studies have directly examined the contribution of specific neurotransmitter receptors to mephedrone’s discriminative stimulus effects. The present study investigated the role of dopamine and serotonin receptors in these effects. Eight adult male Sprague-Dawley rats were trained to discriminate 3.0 mg/kg mephedrone from saline. After dose-response curves were determined with mephedrone (0.375-3.0 mg/kg), a series of stimulus antagonism tests were conducted with dopamine antagonists (Sch 23390, haloperidol) and serotonin antagonists (WAY 100,635, MDL 100,907, pirenperone) administered as …

The Effects Of Low Dose Lysergic Acid Diethylamide Administration In A Rodent Model Of Delay Discounting, Robert J. Kohler

Dissertations

The resurgence of Lysergic Acid Diethylamide (LSD) as a therapeutic tool requires a revival in research, both basic and clinical, to bridge gaps in knowledge left from a previous generation of work. Currently, no study has been published with the intent of establishing optimal microdose concentrations of LSD in an animal model. In the present study, rats were administered a range of LSD doses to quantify potential augmentations in choice behavior in a rodent model of delay discounting. In the first experiment, rats were administered LSD (20 or 40 μg/kg, i.p.) or saline at the start of terminal baseline training …

Differential Effects Of Methylenedioxypyrovalerone (Mdpv) And Mephedrone In Rats Trained To Discriminate Mdma Or A D-Amphetamine+Mdma Mixture, Eric Louis Harvey

Masters Theses

Recent reports on the abuse of novel synthetic cathinone derivatives call attention to serious public health risks of these substances. In response to this concern, a growing body of preclinical research has characterized the psychopharmacology of these substances, particularly mephedrone (MEPH) or methylenedioxypyrovalerone (MDPV), noting their similarities to MDMA and cocaine. The present study employed drug discrimination methodology to assess the discriminative stimulus effects of MEPH and MDPV in male Sprague-Dawley rats trained to discriminate 1.5 mg/kg 3,4 methylenedioxymethamphetamine (MDMA) or a mixture of 1.5 mg/kg MDMA and 0.5 mg/kg d-amphetamine (MDMA+AMPH). After establishing dose response functions with each training …

Effects Of Altering Motivation In Pigeons Performing A Titrating-Delayed-Matching-To-Sample Task, Zachary J. Zimmermann

Masters Theses

In order to better understand the role motivating operations (MOs) serve in preceding and evoking behavior, it is useful to examine the effects of whether manipulating motivation can influence performance on tasks with known behavioral outcomes. It is well established that altered stimulus control is responsible for changes in responding on tasks of generalization and discrimination. Therefore, if stimulus control could be influenced by MOs, then perhaps stimulus discriminations could be improved by manipulating the relevant MO. To this end, the effects of altering motivation via food deprivation were examined in pigeons using a titrating-delayed-matching-to-sample task. Additional pharmacological variables (i.e., …

The Neurobehavioral Consequences Of Gestational And Chronic Atrazine Exposure In Male And Female Sprague Dawley Rats, Jennifer L. Walters

Dissertations

The adverse health risks of exposure to the herbicide, atrazine, in humans are not fully understood. Although numerous studies have demonstrated atrazine to be an endocrine disrupter, the neurobehavioral consequences of atrazine exposure have not been thoroughly examined. The aim of this study was to investigate the effects of environmentally-relevant levels

of gestational followed by continued chronic atrazine exposure on motor function, learning and memory, anxiety, and striatal dopamine content in rodents. Pregnant Sprague Dawley rats were treated by gavage with 100 µg/kg atrazine (ATZ low), 10 me/kg atrazine (ATZ high), or vehicle on

gestational day l through postnatal day …

Short-Term Nicotine Abstinence And Decision Making, Gabriel D. Searcy

Dissertations

Research has shown that acute drug administration may affect impulsivity (i.e., choice for small, immediate rewards over large, delayed rewards) on laboratory delay-discounting tasks. Few studies have investigated how drug abstinence affects impulsivity. Investigating how drug abstinence affects impulsivity may be relevant to preventing relapse. Two previous studies have investigated the effects of short-term nicotine abstinence on impulsivity using delay-discounting tasks. The results were mixed, one study suggested that choices became more impulsive (i.e., delayed money was devalued) under nicotine deprivation. One goal of the present research was to further investigate how nicotine deprivation affects delay-discounting for money rewards. In …

Evaluation Of A School-Based Program Targeting Pediatric Asthma Self-Management Skills In An Urban Population, Dawn J. Dore-Stites

Dissertations

Asthma is the most commonly diagnosed chronic disorder in childhood and is linked with several problematic outcomes including frequent school absences, increased hospitalizations and decreased quality of life. Further, urban populations struggling with low socioeconomic status are disproportionately represented in prevalence statistics and suffer from increased functional morbidity relative to other children with asthma. These findings exist in the midst of largely effective pharmacological interventions.

Asthma self-management programs (SMPs) target several behaviors linked to improved outcomes and are often used as an adjunct to medication management. SMPs have been employed using a variety of techniques and treatment targets in a …

The Effects Of Gamma-Hydroxybutyrate On Response Acquisition, Sean Patrick Laraway

Dissertations

In the last 10 years, the use and abuse of the club drug gamma-hydroxybutyrate (GHB) has noticeably increased. Because GHB has only recently emerged as a drug of abuse, relatively little is known about the drug's behavioral effects, including its effects on learning. Therefore, the present study sought to characterize GHB's effects on rats' acquisition of a lever-press response using a two-lever, resetting/cancellation procedure. Under this procedure, responses on one ( reinforcement ) lever produced a single food pellet after a delay of 0, 20, or 40 s. Presses on the second ( cancellation ) lever during a delay interval …

Assessment N>E Discriminative Stimulus Effects Of (±)-3,4-Methylenedioxymethamphetamine (Mdma, "Ecstasy") And (+Lysergic Add Diethylamide (Lsd) In A Three-Lever Drug Discrimination Procedure, Amy K. Goodwin

Dissertations

(±)3,4-Methylenedioxymethamphetamine (MDMA) is a common drug of abuse known as "ecstasy." Currently, MDMA is classified into the traditional drug classes as both a "stimulant" and a "hallucinogen" because it is reported to share both subjective and physiological properties of both classes. MDMA is thought to produce its psychoactive effects by acting as both a serotonin and a dopamine agonist. However, the relative importance of the serotonin and dopamine neurotransmitter systems in mediating the stimulus properties of MDMA remains unclear.

The drug discrimination assay is used to classify drugs as "similar" or "dissimilar," as well as to examine underlying neurochemical changes …