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Articles 1 - 9 of 9
Full-Text Articles in Biological Psychology
Effects Of Development On Hpa Function Following Pubertal Stress, Brittany D. Elliott
Effects Of Development On Hpa Function Following Pubertal Stress, Brittany D. Elliott
Graduate Theses, Dissertations, and Problem Reports
For women, two of the greatest risk factors for affective disorders are adversity experienced during puberty and later becoming pregnant. We have created a translationally relevant mouse model where we address these complex risk factors. Previously, we discovered that pregnant mice (dams) that experienced chronic variable stress (CVS) during puberty display a blunted hypothalamic-pituitary-adrenal (HPA) response when exposed to an acute stressor. Interestingly, this alteration only first becomes apparent during pregnancy, which is a sensitive period for these effects due to normative neuroendocrine changes. Further investigation of the mechanisms underlying this dysfunction revealed altered gene expression in the paraventricular nucleus …
Sleep And Cardiovascular Reactivity To An Acute Virtual Stressor, Alaina Grace Tiani
Sleep And Cardiovascular Reactivity To An Acute Virtual Stressor, Alaina Grace Tiani
Graduate Theses, Dissertations, and Problem Reports
Inappropriate response and magnitude of cardiovascular reactivity (CVR) to stress is a proposed mechanism through which environmental stressors are linked with poor cardiovascular health outcomes (Chida & Steptoe, 2010; Krantz & Manuck, 1984). Studies of reactivity to various laboratory tasks commonly control for factors known to influence CVR such as smoking, medication use, caffeine intake, and BMI; however, few have considered the influence of sleep on CVR. In order to determine whether sleep characteristics need to be assessed and considered in studies of CVR, this study aimed to examine the association between indices of sleep quality and the magnitude and …
Discriminative Stimulus Effects Of Cannabidiol Oil In Rats, Rebecca L. Chalme
Discriminative Stimulus Effects Of Cannabidiol Oil In Rats, Rebecca L. Chalme
Graduate Theses, Dissertations, and Problem Reports
Cannabidiol (CBD) is one of the major centrally active phytocannabinoid components of cannabis, and has been approved by the FDA only for the treatment of two rare seizure disorders. However, CBD has been touted as a potential treatment for anxiety in place of more traditional treatments like benzodiazepines. Although there is some evidence of anxiolytic effects of CBD, its suitability as a substitute for benzodiazepines is unknown. This experiment was designed to assess to what extent CBD shares interoceptive discriminative-stimulus properties with the anxiolytic chlordiazepoxide (CDP), a benzodiazepine. In the present experiment, a range of doses (0-333.3 mg/kg) of over-the-counter …
Frontal Brain Injury: Effects On Flexibility, Impulse Control, And Attention, Christopher Matthew O'Hearn
Frontal Brain Injury: Effects On Flexibility, Impulse Control, And Attention, Christopher Matthew O'Hearn
Graduate Theses, Dissertations, and Problem Reports
Traumatic Brain Injury (TBI) is defined as an impact to the head, penetration of the skull, or rapid deceleration of the skull, resulting in an alteration of brain function or neurological deficit. Cognitive deficits are common following TBI and often go unresolved due to a lack of effective treatments. These deficits often perseverate into the chronic post injury phase, so the development of rehabilitative strategies is imperative. Behavioral flexibility, impulse control, and attention are a few cognitive processes that are commonly affected by TBI. The current research compares these processes between rats with and without a severe frontal brain injury …
The Role Of High-Fat Diets In Exacerbating Cognitive Deficits After Traumatic Brain Injury, Michelle A. Frankot
The Role Of High-Fat Diets In Exacerbating Cognitive Deficits After Traumatic Brain Injury, Michelle A. Frankot
Graduate Theses, Dissertations, and Problem Reports
Traumatic brain injury (TBI) can cause chronic psychiatric-like impairments that may be driven by inflammation in the brain. In the current study, inflammation was upregulated using a high-fat diet (HFD) to assess the role of inflammation in TBI-induced deficits. Rats were randomly assigned to receive an HFD or calorie-matched low-fat diet (LFD) for the duration of the experiment. After two weeks of free access to their respective diets, rats began behavioral training on the Rodent Gambling Task (RGT), during which they were allowed to freely choose to nosepoke in one of four holes in a standard operant chamber. Responses in …
Minocycline As A Treatment For Traumatic Brain Injury-Induced Impulsive And Attentional Deficits, Kristen M. Pechacek
Minocycline As A Treatment For Traumatic Brain Injury-Induced Impulsive And Attentional Deficits, Kristen M. Pechacek
Graduate Theses, Dissertations, and Problem Reports
Traumatic brain injury (TBI) impacts millions worldwide and can cause lasting psychiatric symptoms. Chronic neuroinflammation is a characteristic of post-injury pathology and is positively associated with psychiatric conditions such as ADHD and bipolar disorder. Therefore, the current study sought to treat TBI-induced impulsivity and inattention using minocycline, an antibiotic with anti-inflammatory properties. Rats were trained on the five-choice serial reaction time task (5CSRT), a measure of motor impulsivity and attention. After behavior was stable on the 5CSRT, rats received either a bilateral frontal TBI or sham procedure. Minocycline was given at either 1 h post-injury or beginning at 8 weeks …
Dispositional Empathy And Autonomic Reactivity During A Comfort Interaction, Alaina G. Tiani
Dispositional Empathy And Autonomic Reactivity During A Comfort Interaction, Alaina G. Tiani
Graduate Theses, Dissertations, and Problem Reports
The purpose of the current study was to examine the association between dispositional (trait) empathy and autonomic reactivity during dyadic interactions among women enrolled in undergraduate psychology courses. The primary research question was: do individuals who are deemed higher in dispositional empathy according to self-report exhibit differential autonomic reactivity patterns during a task in which they are asked to comfort another student experiencing emotional distress than those who are deemed lower in dispositional empathy? The literature on this relation has been mixed and has utilized photos or videos to evoke emotion; thus this study sought to examine the relation between …
Untangling The Reciprocal Relation Of The Behavioral And Physiological Immune Systems, Baris Sevi
Untangling The Reciprocal Relation Of The Behavioral And Physiological Immune Systems, Baris Sevi
Graduate Theses, Dissertations, and Problem Reports
In the past decade, there has been an exponential increase in the study of the Behavioral Immune System (BIS), a suite of psychological processes that serves an infectious disease avoidance function. The BIS is proposed to be inherently intertwined with the physiological immune system. However, very few studies have actually demonstrated this fundamental, theoretical assumption. The purpose of this thesis was to test the possible relation between the physiological and behavioral immune systems in two studies. In Study 1 (N = 388), the relation between implied activation of the physiological immune system and BIS sensitivity was examined. Participants who reported …
Short-Term Abstinence Effects In Experienced Electronic Cigarette Users, Nicholas J. Felicione
Short-Term Abstinence Effects In Experienced Electronic Cigarette Users, Nicholas J. Felicione
Graduate Theses, Dissertations, and Problem Reports
Nicotine/tobacco dependence is a problem that negatively affects health at an individual and population level. Nicotine/tobacco dependence may be best assessed by measuring withdrawal symptoms of a nicotine/tobacco user who abstains from use. Withdrawal symptoms experienced by cigarette smokers are well characterized, including deficits in attention and memory, as well as self-reported cravings, urges, and other symptoms. While withdrawal in cigarette smokers has been studied extensively, little is known about dependence and withdrawal associated with newer products, such as electronic cigarettes (ECIGs). ECIGs can deliver nicotine comparably to tobacco cigarettes, indicating that they may have the potential to cause dependence. …