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Monoamine Modulation Of Separation-Induced Ultrasonic Vocalizations In Preweanling F344 And Sd Rats, Cynthia Elizabeth Britt

Theses Digitization Project

The purpose of this study was to determine if Fischer 344 (F344) rats, a strain which naturally shows deficits in social communication during adolescence, could be used as a model of the social communication deficits observed in autism. Thus, the goal was to determine if F344 rats would also show fewer emissions of isolated-induced ultrasonic vocalizations (an early onset form of social interaction) as compared to SD rats. Subjects consisted of 142 F344 rat pups (67 male and 75 female). Subjects were treated according to the "Guide for the Care and Use of Mammals in Neuroscience and Behavioral Research" under …