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Full-Text Articles in Biological Psychology
Investigating Differing Degrees Of Foxo3a Expression In Adult Neural Stem Cells Between Age Groups In Zebrafish, Francis G. Bacik
Investigating Differing Degrees Of Foxo3a Expression In Adult Neural Stem Cells Between Age Groups In Zebrafish, Francis G. Bacik
Cal Poly Humboldt theses and projects
One factor influencing organismal longevity is the activity of transcription factors of the “fork head domain” family, otherwise known as “Forkhead box” (Fox) proteins. Studies of the four isoforms of the “O” subclass of Fox proteins found in human genes have revealed a direct relationship between FoxO3a-dependent gene expression and the conservation of neural stem cell (NSC) in the adult brain, specifically in the subgranular zone of the dentate gyrus in the hippocampus and the subventricular zone of the cortex. This transcription factor has also been shown to regulate apoptosis in nervous tissue during embryonic development in zebrafish. The current …
Are Caffeine’S Effects On Neuronal Calcium Levels Due To The Caffeine Metabolite, Paraxanthine?, Kendra Jean Hartsuyker
Are Caffeine’S Effects On Neuronal Calcium Levels Due To The Caffeine Metabolite, Paraxanthine?, Kendra Jean Hartsuyker
Cal Poly Humboldt theses and projects
Caffeine has diverse effects on neurons including, potentially, protection against Parkinson’s-related neurodegeneration. Caffeine may protect neurons from damage by limiting mitochondrial membrane permeability through a calcium-dependent mechanism. This study was a first step investigating calcium’s role in caffeine neuroprotection in vivo using zebrafish larvae. Elavl3:GCaMP6s zebrafish, which express a genetically encoded fluorescent calcium indicator protein in most CNS neurons, received caffeine (0, 50, 125, 250 µM, bath applied) in an ascending dose series during fluorescence calcium imaging of a central catecholaminergic nucleus (a proposed zebrafish homolog of the locus coeruleus, a structure affected in Parkinson’s disease). Parallel experiments tested effects …