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Articles 1 - 14 of 14
Full-Text Articles in Biological Psychology
Sucrose Demand And Essential Value In Mice With Early-Life Exposure To Risperidone, Megan Federoff
Sucrose Demand And Essential Value In Mice With Early-Life Exposure To Risperidone, Megan Federoff
LSU Master's Theses
Second-generation antipsychotics (SGAs), such as risperidone, are widely prescribed to children, but the long-term effects of SGA treatment are not well understood. This study investigated the impact of early-life risperidone treatment on sucrose demand in mice in adulthood. Mice were administered risperidone or vehicle from postnatal day (PND) 33 to 60 and trained in adulthood (>PND 120) to nose poke for a sucrose solution reinforcer. The fixed ratio (FR) value (the number of responses required to produce sucrose delivery; the “price” of sucrose) was varied from 1 to 45, and the resulting consumption versus FR value data were analyzed …
Associations Between Cannabis, Psychosis, And Schizophrenia In Adolescents, Lauren Moment
Associations Between Cannabis, Psychosis, And Schizophrenia In Adolescents, Lauren Moment
Academic Leadership Journal in Student Research
The effects of cannabis use on the brain, mind, and body have been studied for decades. The developing brain, particularly the adolescent and young adult brain, undergoes critical development that makes it especially susceptible to the effects of cannabis use. Among the adverse effects of cannabis use in adolescence and young adulthood, psychosis and psychotic disorders (e.g., schizophrenia) have been examined. The association of cannabis use with schizophrenia was first elucidated in a Swedish study of army conscripts. Specifically, conscripts reported their cannabis use exposure and were followed longitudinally to assess the emergence of schizophrenia. The authors found that those …
Sex Differences In The Anatomy Of Mam E17 Treated Rats: A Developmental Model Of Schizophrenia, Cassandra Hartsgrove
Sex Differences In The Anatomy Of Mam E17 Treated Rats: A Developmental Model Of Schizophrenia, Cassandra Hartsgrove
Honors Program Theses and Projects
Enlarged ventricles and reduced cortical volume are neuroanatomical abnormalities correlated with schizophrenia and typically more severe in males. The MAM model of schizophrenia is a developmental disruption model that involves exposing animals to a teratogen, methylazoxymethanol acetate (MAM), to reflect the neuroanatomical traits of schizophrenia. Rodents exposed to MAM on embryonic day 17 (E17) experience a reduction of cortical volume and increased ventricular volume. Measuring brain weight and ventricular volume can be used to inversely measure the severity of cortical reduction. The circling method was used to measure the lateral ventricles of a sample of 27 rodents; 8 MAM-females, 7 …
Decreases In The Frontal Cortical Areas Following A Developmental Disruption Model Of Schizophrenia, Anna Healy
Decreases In The Frontal Cortical Areas Following A Developmental Disruption Model Of Schizophrenia, Anna Healy
Honors Program Theses and Projects
Methylazoxmethanol Acetate (MAM) is a toxin that temporarily blocks mitosis in developing embryonic brains. Exposure in rats on embryonic day 17 (E17) selectively targets frontal and hippocampal regions of the brain and produces behavioral and anatomical effects strikingly similar to those seen in human patients with schizophrenia. While previous studies examining these induced neuroanatomical disruptions support E17 MAM exposure as an animal model of schizophrenia, the vast majority focused on male rats. However, there have been a dearth of studies specifically looking at female rats in this model. This is significant since there is evidence of sex differences in the …
The Effects Of Two Novel Anti-Inflammatory Compounds On Prepulse Inhibition And Neural Microglia Cell Activation In A Rodent Model Of Schizophrenia, Heath W. Shelton
The Effects Of Two Novel Anti-Inflammatory Compounds On Prepulse Inhibition And Neural Microglia Cell Activation In A Rodent Model Of Schizophrenia, Heath W. Shelton
Electronic Theses and Dissertations
Recent studies have shown elevated neuroinflammation in a large subset of individuals diagnosed with schizophrenia. A pro-inflammatory cytokine, tumor necrosis factor-alpha (TNFα), has been directly linked to this neuroinflammation. This study examined the effects of two TNFα modulators (PD2024 and PD340) produced by our collaborators at P2D Bioscience, Inc., to alleviate auditory sensorimotor gating deficits and reduce microglial cell activation present in the polyinosinic:polycytidylic (Poly I:C) rodent model of schizophrenia. Auditory sensorimotor gating was assessed using prepulse inhibition and microglial activation was examined and quantified using immunohistochemistry and confocal microscopy, respectively. Both PD2024 and PD340 alleviated auditory sensorimotor gating deficits …
A Not-So Beautiful Mind: A Review Of The Genetics Of Schizophrenia, Lydia Pack
A Not-So Beautiful Mind: A Review Of The Genetics Of Schizophrenia, Lydia Pack
Oswald Research and Creativity Competition
Schizophrenia is often called “the cancer of the brain” because of the lifelong, horrendous implications of the disease. Though research has been conducted on schizophrenia for a century or more, it has just recently been realized how large a role genetics may play in the development of the disease. This review will discuss why research on schizophrenia genes has been difficult, what genes have been found, how the current treatments are being revolutionized, and how to progress in this field. The difficulty in research is due in part to the complex genetics behind the disease as well as possible environmental …
Effort-Related Decision Making In Comt Variant Mice: Pharmacological Studies And Genetic Susceptibility To Motivational Dysfunction, Suzanne Cayer
Effort-Related Decision Making In Comt Variant Mice: Pharmacological Studies And Genetic Susceptibility To Motivational Dysfunction, Suzanne Cayer
Honors Scholar Theses
Effort-related decision making tasks in animals can model motivational symptoms in humans, which are a set of symptoms spanning a multitude of neuropsychiatric disorders, such as major depressive disorder and the negative symptoms of schizophrenia. The present studies aimed to evaluate the effort-related effects of the Val158Met polymorphism of human catechol-methyltransferase (COMT), by testing mice carrying either the human COMT Val (n=8) or Met allele (n=8) with Wild-Type control mice (n=15) by using concurrent FR2 and FR4/pellet choice tasks in a touchscreen operant conditioning apparatus. The Val158Met polymorphism has been repeatedly associated with neuropsychiatric disorders, and the Val allele has …
The Effects Of Antipsychotic Treatment Upon Nicotine Associative Reward In A Neonatal Quinpirole Model Of Schizophrenia, Adam Ray Denton
The Effects Of Antipsychotic Treatment Upon Nicotine Associative Reward In A Neonatal Quinpirole Model Of Schizophrenia, Adam Ray Denton
Undergraduate Honors Theses
Research has revealed that schizophrenics are significantly more likely to smoke cigarettes than the general population, and consume nicotine products at a much more prevalent rate. Further exacerbating this issue, it has been previously demonstrated in clinical populations that the type of antipsychotic treatment administered (typical versus atypical) may result in either an increase or a decrease of already heightened smoking behavior within the schizophrenic population. With these clinical issues in mind, the present study sought to examine the effects of antipsychotic treatment upon the associative reward of nicotine within the neonatal quinpirole model of schizophrenia. We found that treatment …
Behavioral Phenotyping Of Vmat1 Knockout Mice: Relevance To Neuropsychiatric Disorders, Kevin A. Webster Ph.D.
Behavioral Phenotyping Of Vmat1 Knockout Mice: Relevance To Neuropsychiatric Disorders, Kevin A. Webster Ph.D.
Theses and Dissertations
Schizophrenia is a debilitating mental disorder that causes a large economic burden and is prevalent across all cultures and countries around the world. Although both environmental factors and genetics are known to play an important role in the etiology of schizophrenia, the exact role of genetics and its interaction with environmental factors in an individual’s predisposition to develop schizophrenia is poorly understood. Schizophrenia is characterized by symptoms that include positive symptoms (e.g. delusions, hallucinations, disorganized thinking and speech), negative symptoms (e.g. avolition, anhedonia, depressive-like behavior), and cognitive dysfunctions (e.g. executive functioning deficits in learning and memory, attention, and vigilance). Genomic …
Breaking Apart The Reinforcement Learning Deficit In Schizophrenia, Adam Culbreth
Breaking Apart The Reinforcement Learning Deficit In Schizophrenia, Adam Culbreth
Arts & Sciences Electronic Theses and Dissertations
Reinforcement learning deficits have long been associated with schizophrenia. However, tasks traditionally used to assess these deficits often rely on multiple processing streams leaving the etiology of these task deficits unclear. In the current study, we borrowed a recent framework from computational neuroscience, which separates reinforcement-learning into two distinct systems, model-based and model-free. Under this framework, the model-free system learns about the value of actions in the immediate context, while the model-based system learns about the value of actions in both immediate and subsequent states that may be encountered as a result of their actions. Using a decision task that …
Electrophysiological Changes In P200 Latency And Amplitude Of Jittered Orientation Visual Integration Task In Healthy Participants: A Multi-Block Design Eeg Study, Monika M. Rozynski, Chi-Ming Chen
Electrophysiological Changes In P200 Latency And Amplitude Of Jittered Orientation Visual Integration Task In Healthy Participants: A Multi-Block Design Eeg Study, Monika M. Rozynski, Chi-Ming Chen
Honors Scholar Theses
Visual integration, the ability to fuse environmental information such as light, color, shades, and motion to form a representation of a whole cohesive higher-order visual image, is impaired in persons with schizophrenia. Little is known how the P200 component, an event-related potential (ERP) in the parieto-occipital region, is affected in persons with schizophrenia while they perform visual integration tasks, when compared to healthy persons. This study administered Gabor contours that varied in high and low degrees of orientational jitter through the Jitter Orientation Visual Integration (JOVI) task to investigate visual integration by analyzing latency and amplitude of the P200 component. …
Ketamine Induced Deficits In Working Memory With Relevance To Schizophrenia, Michael A. Langhardt, Jefferson Kinney
Ketamine Induced Deficits In Working Memory With Relevance To Schizophrenia, Michael A. Langhardt, Jefferson Kinney
McNair Poster Presentations
Schizophrenia is a chronic debilitating brain disorder, which affects approximately one percent of the adult population worldwide. The symptoms of schizophrenia are commonly divided into three broad classes: positive symptoms, negative symptoms, and cognitive disturbances (Kay, et al., 1987). The positive symptoms of schizophrenia include hallucinations, delusions, and disorganized thinking, while the negative symptoms include affective flattening, social withdrawal, and an inability to plan and carry out future activities. The cognitive disturbances exhibited in schizophrenia include deficits in spatial reference and working memory as well as difficulties with focus and attention (Lewis et. al., 2007). Several models have been proposed …
The Glutamate Hypothesis Of Schizophrenia: Assessment Of A Novel Antipsychotic In Zebrafish Larvae, William Vitale
The Glutamate Hypothesis Of Schizophrenia: Assessment Of A Novel Antipsychotic In Zebrafish Larvae, William Vitale
Senior Projects Spring 2012
The glutamate hypothesis is a new theory of schizophrenia which proposes that deficient glutamatergic transmission at the NMDA receptor underlies the positive, negative, and cognitive symptoms of the disorder. In addition to tracing the development of the glutamate hypothesis in depth, this senior project presents a study investigating the effects of a novel antipsychotic in zebrafish. Zebrafish are an emerging model of several CNS disorders, including schizophrenia, and it has been demonstrated that NMDA-R antagonism induces motor hyperactivity in zebrafish adults and larvae. Previous research supports an ability of typical and atypical antipsychotics to reverse these motor effects in zebrafish …
Schizophrenia: A Critical Examination, Charles A. Sanislow, Robert C. Carson
Schizophrenia: A Critical Examination, Charles A. Sanislow, Robert C. Carson
Charles A. Sanislow, Ph.D.
No abstract provided.