Biological Psychology Commons^™

Amygdala Hyperreactivity In Borderline Personality Disorder: Implications For Emotional Dysregulation, Nelson H. Donegan, Charles A. Sanislow, Hilary P. Blumberg, Robert K. Fulbright, Cheryl Lacadie, Pawel Skudlarski, John C. Gore, Ingrid R. Olson, Thomas H. Mcglashan, Bruce E. Wexler

Charles A. Sanislow, Ph.D.

BACKGROUND: Disturbed interpersonal relations and emotional dysregulation are fundamental aspects of borderline personality disorder (BPD). The amygdala plays important roles in modulating vigilance and generating negative emotional states and is often abnormally reactive in disorders of mood and emotion. The aim of this study was to assess amygdala reactivity in BPD patients relative to normal control subjects. We hypothesized that amygdala hyperreactivity contributes to hypervigilance, emotional dysregulation, and disturbed interpersonal relations in BPD.

METHODS: Using functional magnetic resonance imaging, we examined neural responses to 20-sec blocks of neutral, happy, sad, and fearful facial expression (or a fixation point) in 15 …

The Practice Of Adoption: History, Trends, And Social Context, Amanda Baden, Kathy P. Zamostny, Karen M. O'Brien, Mary O'Leary Wiley

Department of Counseling Scholarship and Creative Works

This article presents an overview of the practice of adoption to counseling psychologists to promote clinical understanding of the adoption experience and to stimulate research on adoption. The article includes definitions of adoption terminology, important historical and legal developments for adoption, a summary of adoption statistics, conceptualizations of adoption experience, themes and trends in adoption outcome research related to adoptees and birthparents, and selected theoretical models of adoption. The importance of considering social context variables in adoption practice and research is emphasized.

A Longitudinal Examination Of Flow As A Predictor Of Recreational Exercise, Brian Michael Chichester

Loma Linda University Electronic Theses, Dissertations & Projects

Flow state is a valued psychological state of enjoyment and well-being. It is characterized by feelings of intrinsic self-reward and marked by nine dimensions theorized to contribute to flow state. Flow has been studied mostly in elite athletes, whom report highly lucid flow experiences; to a much lesser extent it has been studied in recreational exercisers. Most prior research methodologies involve experience sampling or qualitative techniques, such as interviewing. Only one demonstrably valid and reliable flow instrument is widely available for efficient, quantitative measure of flow experiences. This study measures flow longitudinally in a recreational exercising population by comparing a …

Validation Of A Serotonin Checklist In A Parkinson’S Disease Population, Kelly Diane Darby-Holder

Loma Linda University Electronic Theses, Dissertations & Projects

Although the distinctive pathological marker of Parkinson’s Disease is the progressive death of neurons that produce dopamine, there are also alterations in the production of quantities of other neurotransmitters, such as norepinephrine and serotonin that contribute to the disease. Parkinson’s Disease (PD) can be divided into two distinct classes based on the manifestation of motor symptoms, Type A and Type B Parkinson’s Disease. Type B PD patients often manifest symptoms in which serotonin deficiency plays an important role, which often includes a history of depression. Within the brain and spinal cord serotonin has wide spread projections, acting as an important …

The Representation Of Four Personality Disorders By The Schedule For Nonadaptive And Adaptive Personality Dimensional Model Of Personality, Leslie C. Morey, Megan B. Warner, M. Tracie Shea, John G. Gunderson, Charles A. Sanislow, Carlos M. Grilo, Andrew E. Skodol, Thomas H. Mcglashan

Charles A. Sanislow, Ph.D.

This study examined the relationships of the Schedule for Nonadaptive and Adaptive Personality (SNAP) model of personality to 4 targeted personality disorders (PDs) in a large multisite sample of patients. Data were examined from 529 patients, who were assigned 1 of 5 primary diagnoses: borderline, schizotypal, avoidant, and obsessive–compulsive PDs and major depression without PD. Patients were administered the SNAP questionnaire and results were compared among diagnostic groups and between patient groups and nonclinical norms. Results indicated that the dimensions of the model appear to have considerable promise in differentiating normal from abnormal personality, particularly in the propensity of individuals …

Neural Correlates Of Memories Of Abandonment In Women With And Without Borderline Personality Disorder, Christian G. Schmahl, Bernet M. Elzinga, Eric Vermetten, Charles A. Sanislow, Thomas H. Mcglashan, J. Douglas Bremner

Charles A. Sanislow, Ph.D.

BACKGROUND: Borderline personality disorder (BPD) is a common psychiatric disorder that is often linked to early stressors. One particularly salient feature of the disorder is fear of abandonment. This pilot study was conducted to measure neural correlates of memories of abandonment in women with and without BPD.

METHODS: Twenty women with a history of childhood sexual abuse underwent measurement of brain blood flow with positron emission tomography imaging while they listened to scripts describing neutral and personal abandonment events. Brain blood flow during exposure to abandonment and neutral scripts was compared among women with and without BPD.

RESULTS: Memories of …

Gender Differences In Borderline Personality Disorder: Findings From The Collaborative Longitudinal Personality Disorders Study, Dawn M. Johnson, M. Tracie Shea, Shirley Yen, Cynthia L. Battle, Caron Zlotnick, Charles A. Sanislow, Carlos M. Grilo, Andrew E. Skodol, Donna S. Bender, Thomas H. Mcglashan, John G. Gunderson, Mary C. Zanarini

Charles A. Sanislow, Ph.D.

A majority of the literature on borderline personality disorder (BPD) focuses on its occurrence in women or does not specifically assess for gender differences in clinical presentations. Some studies report that men with BPD may be more likely to be diagnosed with substance use disorders, as well as paranoid, passive-aggressive, narcissistic, sadistic, and antisocial personality disorders (PDs). Additionally, women with BPD appear to be more likely to report histories of adult physical and sexual abuse and to meet diagnostic criteria for post-traumatic stress disorder (PTSD) and eating disorders. The purpose of the present study was to further examine gender differences …

The Effects Of Gamma-Hydroxybutyrate On Response Acquisition, Sean Patrick Laraway

Dissertations

In the last 10 years, the use and abuse of the club drug gamma-hydroxybutyrate (GHB) has noticeably increased. Because GHB has only recently emerged as a drug of abuse, relatively little is known about the drug's behavioral effects, including its effects on learning. Therefore, the present study sought to characterize GHB's effects on rats' acquisition of a lever-press response using a two-lever, resetting/cancellation procedure. Under this procedure, responses on one ( reinforcement ) lever produced a single food pellet after a delay of 0, 20, or 40 s. Presses on the second ( cancellation ) lever during a delay interval …

Finding The Feathers In “Birds Of A Feather”: An Antiterrorist And Counterterrorist Dilemma In Profiling, Ibpp Editor

International Bulletin of Political Psychology

This article describes a significant challenge for intelligence analysts attempting to identify individuals, groups, and organizations that have joined, are joining, or will join forces in terrorist enterprises.

The World Wide Web And The Laboratory: A Comparison Using Face Recognition, Mitchell M. Metzger, Valerie L. Kristof, Yoest J. Donald

Mitchell Metzger, PhD

No abstract provided.

Long-Term Effects Of 3,4- Methylenedioxymethamphetamine (Mdma) On Serotonergic And Dopaminergic Functioning, Jodi Lynn Kohutek

Theses Digitization Project

Methylenedioxymethamphetamine (MDMA) popularly known as "Ecstasy" continues to gain popularity as a recreational drug that has been shown to increase serotonin and dopamine levels. The present study has demonstrated that repeated exposure to MDMA produces long-term damage to serotonergic and dopaminergic neurons in various regions of the rat brain.

The Effects Of Lesions To The Superior Colliculus And Ventromedial Thalamus On [Kappa]-Opioid-Mediated Locomotor Activity In The Preweanling Rat, Arturo Rubin Zavala

Theses Digitization Project

The purpose of this thesis was to determine the neuronal circuitry mediating U50,488-induced locomotion in preweanling rats. To this end, preweanling rats received bilateral electrolytic lesions of the ventromedial thalamus or superior colliculus and, two days later, the same rats received a challenge injection of U50,488. It was predicted that bilateral lesions of the ventromedial thalamus or superior colliculus would attenuate the U50,488-induced locomotor activity of 18-day-old rats.

Acutely-Administered Ethanol Participates In Testosterone Synthesis And Increases Testosterone In The Rat Brain., Laura O'Dell

Laura Elena O'Dell

No abstract provided.

Induction And Expression Of Cocaine-Induced Behavioral Sensitization: Modulation By A Partial D₂-Like Agonist, Janet Marie Sibole

Theses Digitization Project

The purpose of this study was to investigate whether a partial D₂-like dopamine agonist (i.e. terguride) would block the induction or expression of cocaine-induced behavioral sensitization in pre-weanling rats. The ability of terguride to induce behavioral sensitization was also examined, as partial D₂-like agonists have agonistic actions in cases of low dopaminergic tone.

Plausibility And Possible Determinants Of Sudden 'Remissions' In Borderline Patients, John G. Gunderson, Donna S. Bender, Charles A. Sanislow, Shirley Yen, Jennifer Bame Rettew, Regina Dolan-Sewell, Ingrid R. Dyck, Leslie C. Morey, Thomas H. Mcglashan, M. Tracie Shea, Andrew E. Skodol

Charles A. Sanislow, Ph.D.

THIS STUDY documents dramatic improvements in patients with borderline personality disorder (BPD) and explores their possible determinants. From a sample of the 160 carefully diagnosed borderline patients on whom prospective follow-along data was collected, a subsample of 18 was identified whose DSM-IV criteria count fell to two or fewer during the course of the first 6 months of the study and retained that improvement for the next 6 months. Follow-along data including month-by-month ratings of BPD criteria; week-by-week ratings of Axis I disorders, medication changes, and life events were then used to establish concensus ratings on four hypothesized causes: Axis …