Biological Psychology Commons^™

Identifying Trauma Related Predictors Of Dissociation In Maltreated Youth, Amanda L. Mraz

UNLV Theses, Dissertations, Professional Papers, and Capstones

Maltreated youth who experience traumatic dissociation are at an increased risk for various psychopathological difficulties. Much is still unknown about the machinations behind experiences of dissociation post-trauma. This study aimed to identify variables that place maltreated youth at risk for experiencing traumatic dissociation (e.g., dissociative amnesia, absorption and imaginative involvement, passive influence, depersonalization and derealization, and total adolescent dissociative experiences symptoms (A-DES)). Investigatory variables included demographic (e.g., age, gender, and racial identity), cognitive (e.g., resiliency and posttraumatic cognitions), and psychological (e.g., posttraumatic stress disorder symptoms (PTSD) and anxiety) factors. Classification and regression tree (CART) analysis was utilized to observe the …

Examination Of Performance Validity And The Relationship To Cognition And Symptoms In Schizophrenia Spectrum Disorders, Erick A. Rogers

UNLV Theses, Dissertations, Professional Papers, and Capstones

Approximately one-in-five individuals with psychotic disorders (i.e., schizophrenia spectrum disorders [SSD]) fail performance validity indicators (PVIs) during neurocognitive testing. Ensuring the validity of neurocognitive test results is necessary if the test scores are to be of use for diagnostic consideration, intervention selection and planning, predicting outcomes, and following changes in cognition over time in response to intervention, spontaneous recovery, or disease progression. PVIs are designed to require only a minimum level of engagement with the evaluation, which means nearly everyone is expected to “pass,” even those with moderate to severe brain damage. Traditional interpretations of PVI failure suggest a noncredible …

Using Motor Imagery As An Alternative To Exercise For Improvement Of Mental Health: A Qualitative Investigation, Madelyn Colbert

Spectra Undergraduate Research Journal

Exercise is a commonly used non-pharmacological treatment to improve the mental and physical health of patients with varying conditions. However, not all patients have the means to participate in exercise and/or physical exertion. Motor imagery training (MIT) is visualizing a task without motor output. Evidence has demonstrated MIT to enhance physical function with and without adjacent physical practice. A qualitative research study was conducted to examine the effectiveness of utilizing MIT as a depression and anxiety reducing alternative to exercise. Seven participants meeting the selection criteria were randomized into (a) the exercise group, or (b) the MIT group. The three …

Is Pristine Inner Experience Linked To Biology? An Examination Of Experience Across The Menstrual Cycle Among Women With Premenstrual Distress, Alek E. Krumm

UNLV Theses, Dissertations, Professional Papers, and Capstones

The link between mind and biology is intuitively known: We notice changes in our mood and behavior when hungry, in pain, or under the influence of substances. Yet, the specifics of this link—for example, how changes in biology affect directly apprehended conscious experience— are not well known. The present study was an exploratory attempt toward filling that gap by using a state-of-the-art, beeper-driven method for exploring directly apprehended conscious experience (Descriptive Experience Sampling; DES) across one of the most predictable and wellknown biological cycles: menstruation. We screened approximately 300 college women to identify those who reported clinically significant symptoms of …

Validating Empathy As Captured By The Meanness In Psychopathy-Self Report, Stephanie Marie Molina

UNLV Theses, Dissertations, Professional Papers, and Capstones

Psychopathy is a distinctive personality disorder with an array of interpersonal and affective deficits. In particular, deficits in affective and cognitive empathy skills are noted to be a central feature of psychopathy. Specifically, the construct of psychopathic meanness, which is conceptualized as a tendency to act aggressively without regard for others, is preferentially related to deficient empathy. To elucidate the relationship between psychopathic meanness and empathy, three studies were conducted utilizing the Meanness in Psychopathy-Self Report (MiP- SR). The MiP-SR is a new measure that parses apart the construct of psychopathic meanness into three factors: Malice, Coldness, and Imperviousness. MiP-SR …

Developmental Seizures And Mortality Result From Reducing Gabaa Receptor Α2-Subunit Interaction With Collybistin, Rochelle M. Hines, Hans Michael Maric, Dustin J. Hines, Amit Modgil, Patrizia Panzanelli, Yasuko Nakamura, Anna J. Nathanson, Alan Cross, Tarek Deeb, Nicholas J. Brandon, Paul Davies, Jean-Marc Fritschy, Hermann Schindelin, Stephen J. Moss

Psychology Faculty Research

Fast inhibitory synaptic transmission is mediated by γ-aminobutyric acid type A receptors (GABAARs) that are enriched at functionally diverse synapses via mechanisms that remain unclear. Using isothermal titration calorimetry and complementary methods we demonstrate an exclusive low micromolar binding of collybistin to the α2-subunit of GABAARs. To explore the biological relevance of collybistin-α2-subunit selectivity, we generate mice with a mutation in the α2-subunit-collybistin binding region (Gabra2-1). The mutation results in loss of a distinct subset of inhibitory synapses and decreased amplitude of inhibitory synaptic currents. Gabra2–1 mice have a striking phenotype characterized by increased susceptibility to seizures and early mortality. …

Experiencing Parental Loss During Adolescence And Factors Influencing Hospital Involvement And The Grieving Process, Vaida Kazlauskaite

UNLV Theses, Dissertations, Professional Papers, and Capstones

Experiencing the death of a loved one can be traumatic and painful to anyone. Adolescents in particular experience death in a unique way, during a time in their lives when they are developing their own autonomy and independence. Experiencing the deteriorating conditions of a terminally ill parent may affect an adolescent in many ways. However, there is relatively little research on adolescent involvement in the medical setting during a parent’s terminal illness and how this may affect the adolescent’s bereavement. This qualitative study utilized heuristic inquiry and procedures of Grounded Theory to investigate factors influencing the involvement in the hospital …

A Comparison Of The Effects Of Different Doses Of Gabab Receptor Ligands On Spatial Learning And Memory And Memory Flexibility, Chelcie Heaney

UNLV Theses, Dissertations, Professional Papers, and Capstones

The principal inhibitory neurotransmitter in the brain, gamma amino-butyric acid (GABA), mediates several types of learning and memory. Of the two main receptor subtypes for GABA, the in vivo role of GABAB receptor in learning and memory is less well characterized and the current data often conflict. Based on the current literature, it is unclear, for instance, whether enhancing GABAergic activity via the GABAB receptor could be beneficial for or detrimental to learning and memory. Hippocampally-dependent learning and memory tasks are of particular interest due to their clinical relevance to patients with schizophrenia or Alzheimer’s disease, who exhibit impaired performance …

Faculty Recital, Nathan Tanouye, Albina Asryan

Faculty Recitals

No abstract provided.

The Effect Of Acute Lps-Induced Immune Activation And Brain Insulin Signaling Disruption In A Diabetic Model Of Alzheimer's Disease, Andrew Scott Murtishaw

UNLV Theses, Dissertations, Professional Papers, and Capstones

Alzheimer's disease (AD) is a neurodegenerative disorder marked by progressive cognitive impairments and pathological hallmarks that include amyloid plaques, neurofibrillary tangles, and neuronal loss. Several well-known mutations exist that lead to early-onset familial AD (fAD). However, these cases only account for a small percentage of total AD cases. The vast majority of AD cases are sporadic in origin (sAD) and are less clearly influenced by a single mutation but rather some combination of genetic and environmental risk.

The etiology of sAD remains unclear but numerous risk factors have been identified that increase the chance of developing AD. Among these risk …

Implicit Theories Of Intelligence And Learning A Novel Mathematics Task, Nathan Oehme Rudig

UNLV Theses, Dissertations, Professional Papers, and Capstones

The social-cognitive model of motivation states that students adopt a theory of the nature of intelligence that guides their goals in academia and their responses to academic setbacks. Students who believe intelligence is an unchanging entity within them are more likely to adopt goals to display high ability, hide low ability, and respond helplessly to failed schoolwork. Conversely, a student who believes intelligence is a measure of effort and persistence will be motivated to gather knowledge and acquire new skills. The current study investigated the role theories of intelligence play in the field of mathematics understanding. In two experiments, participants …

The Effect Of Early Life Stress On Methamphetamine Damage In The Striatum, Emily Hensleigh

UNLV Theses, Dissertations, Professional Papers, and Capstones

Methamphetamine (METH) abuse impacts the global economy through costs associated with drug enforcement, emergency room visits, and treatment. Hyperthermia is a leading cause of METH induced emergency room visits and may lead to neural damage. Previous research has demonstrated early life stress, such as childhood abuse, increases the likelihood of developing a substance abuse disorder. However, the effects of early life stress on neuronal damage induced by chronic METH administration are unknown. We aimed to elucidate the effects of early life stress on METH induced dopamine damage in the striatum. Animals were separated three hours per day during the first …

Early Life Stress, Drug Abuse, Exercise Effects On Bdnf And Sex-Influenced Excercise Differences, Karissa Dold

Honors College Theses

In 2011, the U.S. reported 3 million child maltreatment cases, an uncomfortably high but recurring figure each year. Research shows exposure to early life stress (ELS) increases an individual’s susceptibility to substance abuse, specifically of nicotine, alcohol, and cocaine. Increased susceptibility may result from dysregulation of the HPA axis sustaining activation into adulthood after ELS. Hyperactivation of the HPA axis significantly reduces hippocampal BDNF, a neurotrophin involved in neuronal growth and plasticity. Reduced hippocampal BDNF may be a factor in substance abuse vulnerability. Additionally, research shows exercise protects hippocampal BDNF from stress induced down-regulation. To explore these relationships, this study …

Untangling Cultural Differences In Behavioral, Physiological, And Psychological Symptoms Of Dementia And Alzheimer’S Disease, John S. Avant

Calvert Undergraduate Research Awards

According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR; 4^th ed. Revised; American Psychiatric Association) and (BPSD) there are many behavioral, physiological, and psychological issues that have been correlated with the progression of the Alzheimer’s disease and other dementias. Examples of these issues include; emotional regulation problems, variations in eating behavior, and an advancing decline in memory. Though certain symptoms of the disease seem to be widely universal, current literature shows that a number of disparities do exist. There are several differences between and within populations suffering from Alzheimer’s disease and dementia that are influenced by various …

Ketamine Induced Deficits In Working Memory With Relevance To Schizophrenia, Michael A. Langhardt, Jefferson Kinney

McNair Poster Presentations

Schizophrenia is a chronic debilitating brain disorder, which affects approximately one per­cent of the adult population worldwide. The symptoms of schizophrenia are commonly divided into three broad classes: positive symptoms, negative symptoms, and cognitive disturbances (Kay, et al., 1987). The positive symptoms of schizophrenia include hallucinations, delusions, and dis­organized thinking, while the negative symptoms include affective flattening, social withdrawal, and an inability to plan and carry out future activities. The cognitive disturbances exhibited in schizophrenia include deficits in spatial reference and working memory as well as difficulties with focus and attention (Lewis et. al., 2007). Several models have been proposed …

Pain Tolerance And Thresholds In Women With Dyspareunia: Do Pain And Sex Primes Have Differential Effects?, Lea Thaler

UNLV Theses, Dissertations, Professional Papers, and Capstones

Dyspareunia, defined as recurrent pain in the genital/pelvic region during sexual intercourse, is one of the most common types of female sexual dysfunction, affecting approximately 15% of women between the ages of 18 and 24. Women with dyspareunia display similar cognitive and emotional styles evidenced in other chronic pain conditions (e.g. hypervigilance for pain information, catastrophization, and negative affect); however, dyspareunia is a unique pain disorder in that it directly involves sexual functioning. This pairing of pain and sex raises the issue of conditioning. Is it possible that because intercourse is painful for women with dyspareunia, the presentation of any …

International Study Program For Indoor Environmental Research, Stoil Pamoukov

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study examined the effect on student performance, perception and mood caused by different physical classroom environmental conditions. Three classroom physical environmental conditions were investigated; room temperature, light intensity and sound level. A two phase pilot study was performed where these conditions were compounded into one and two levels were selected in such a way to create a normal and extreme classroom physical environment. A total of 154 undergraduate UNLV students participated in the two phase pilot laboratory study in which they completed tasks related to reading and listening to an oral presentation of a passage of high density technical …

Testosterone And Vasopressin In Men’S Reproductive Behavior, Eric T. Steiner

UNLV Theses, Dissertations, Professional Papers, and Capstones

One common practice used by researchers is to divide human reproduction into two major domains: mating and parenting. Adaptive problems men faced over the millennia may have produced evolutionary pressure for hormone responses and behavior that facilitate both mating and parenting, either separately or simultaneously. The sometimes competing domains of mating and parenting in men are often mediated by a number of the same hormones, such as testosterone (T) and arginine vasopressin (AVP). One aim of the current study was to examine differences in baseline levels of T and AVP between childless men who were not in an exclusive, romantic …

The Effect Of Early Environmental Manipulation On Locomotor Sensitivity And Methamphetamine Condition Place Preference Reward, Emily Hensleigh

UNLV Theses, Dissertations, Professional Papers, and Capstones

Early life stress has drastic effects on neurological development, affecting health and well-being later in life. Instances of child abuse and neglect are associated with higher rates of depression, risk taking behavior, and an increased risk of drug abuse later in life (Chapman,D.P. 2004; Dube,S.R. 2003). This study used repeated neonatal separation of rat pups as a model of early life stress. Rat pups were either handled and weighed as controls or separated for 180 minutes per day during postnatal days 2-8. In adulthood, rats were tested for methamphetamine conditioned place preference reward and methamphetamine induced locomotor activity. Tissue samples …

Neuropsychological And Emotion Processing Abnormalities In Bipolar Disorder I And Ii, Carol Randall

UNLV Theses, Dissertations, Professional Papers, and Capstones

Bipolar disorder illness is marked by emotional lability and mood disturbance, as well as various neuropsychological deficits, and the neuroanatomical correlates of many of these deficits are beginning to be identified. Numerous studies have implicated specific cortical and sub-cortical abnormalities in areas associated with executive function, memory, motor function, and the processing of emotion. Although a large body of research has been devoted to the investigation of cognitive and emotion-processing deficits in bipolar disorder, relatively few studies have been devoted to the investigation of how these deficits differ among bipolar disorder subtypes. This is surprising in light of known symptomatological …

Examining The Inner Experience Of Left-Handers Using Descriptive Experience Sampling, Aadee Mizrachi

UNLV Theses, Dissertations, Professional Papers, and Capstones

Research suggests that there are anatomical asymmetries of the human brain in relation to hand preference. In addition, left-handedness has been related to a wide range of psychological and physical problems. Despite these relationships, little is known about the inner experience of left-handers. The present study used Descriptive Experience Sampling (DES) to explore the inner experience of 6 left-handed participants. Descriptive Experience Sampling is a nonquantitative sampling method designed to explore and describe inner experience. Undergraduate psychology students were recruited from UNLV to participate in the study. Recruitment consisted of three phases: screening, qualification, and sampling. Students who reported writing …

Taking Charge Of Adult Adhd, P. S. Mcmillen

Library Faculty Publications

Barkley is one of the leading researchers and most prolific writers on attention deficit/hyperactivity disorder (ADHD) across the life span, having produced materials for mental health professionals and self-help books like this volume.