Biological Psychology Commons^™

Effects Of Foster Children’S Epigenetics In Abusive Environments, Shamika Ellis, Theresa Moore

Undergraduate Research Symposium

Abstract: Effects of Foster Children’s Epigenetics in Abusive Environments

Shamika Ellis, Theresa A. Moore, Hannah B. White, PhD

This presentation will review the literature on the epigenetics of abused foster children, and the subsequent acute, delayed, and long-term physiological, cognitive, and behavioral effects. One study experimentally investigated the effects of sexual and physical abuse on 150 foster children from 8 to 19 years of age and found post-traumatic stress disorder (PTSD) was diagnosed in 64% of children who experienced sexual abuse and 42% of children who experienced physical abuse Further, of the foster children who had not experienced either form …

Hiv And Early Life Stress On Neuroimaging And Risky Behavior, Paola Garcia Egan

Dissertations

This study examined the interactive effects of early life stress (ELS) and HIV on brain morphometry, diffusion-basis-spectrum-imaging (DBSI), risky decision-making, and sex-risk behavior. 122 people with HIV (PWH) and 113 people without HIV (PWoH), free of major psychiatric illness and neurological confounds, were stratified into high (≥ 3 events) vs. low (< 3 events) ELS [PWoH/low ELS (n = 57), PWoH/high ELS (n =56), PWH/low ELS (n = 43), PWH/high ELS (n = 79)] and underwent structural magnetic resonance imaging, DBSI, neuropsychological, and risky-behavior assessment; all PWH were virologically controlled. Compared to PWoH, PWH had smaller orbitofrontal cortex (OFC), parietal lobes, insula, caudate and anterior cingulate. No ELS effects were detected in volumetric measures. Significant interactions were found between HIV serostatus and ELS on the OFC and on cellularity of the inferior fronto-occipital fasciculus after multiple comparisons adjustment. Specifically, PWH/high ELS exhibited significantly smaller OFC and PWoH/high ELS show significantly larger OFC than the other groups. PWoH/high ELS exhibited higher DBSI cellularity (neuroinflammation proxy) of the inferior-occipital-fasciculus compared to PWoH/high ELS. Regardless of HIV status, executive function moderated the relationship between the OFC and sex-risk behavior such that individuals within the sample who performed above average on a measure of executive function and had a larger OFC reported fewer sex partners in past six months than individuals with smaller volumes. No interaction was found between HIV serostatus and ELS on risky behavior measures. Clustering analyses defined ELS subgroups in PWH that were determined by demographic characteristics, duration of infection, recent CD4+ T-cell count, nadir CD4+ T-cell count and high/low ELS.Even in PWH that are virologically controlled, without major current psychiatric comorbidities, there is evidence of a synergistic impact of ELS and HIV on OFC volumes. Higher volumes in the OFC were detrimental when associated with lower executive function scores or advantageous when associated with higher executive function. Findings suggest that ELS is associated with different brain signatures among PWoH and virally suppressed PWH. However, ELS was not directly associated with risky behaviors, and subgroups in PWH were characterized by demographic variables, past substance use and HIV clinical variables.

Cortisol Administration Normalizes Aberrant Functional Connectivity In Women With Depression, Adam C. Runyan

Dissertations

Previous resting-state functional connectivity (rsFC) research has identified aberrant connectivity in several large brain networks in depression, including the default mode (DMN), frontoparietal (FPN), and salience networks (SN). Connectivity of these networks is also related to depressive symptom severity and is affected by cortisol levels. To our knowledge, this is the first study to investigate the effects of acute cortisol administration on rsFC of DMN, FPN, and SN in individuals varying in depression history and severity. We collected resting-state fMRI scans for 74 women with and without a history of depressive disorder after administration of cortisol and placebo using a …

Heart Rate Variability Following Treatment For Ptsd: Testing The Polyvagal Theory, Brittany F. Goodman

Dissertations

Posttraumatic stress disorder (PTSD) has been linked to lower heart rate variability (HRV), including measures of vagal tone. Treatments targeting the autonomic nervous system (ANS) have demonstrated efficacy in improving vagal tone, but it is less clear whether similar effects can also be achieved with cognitive therapies. The polyvagal theory has suggested that symptoms of social dysfunction are linked to vagal tone through a phylogenetically organized response to stress. HRV was collected during rest, reactivity (exposure to personalized trauma scripts), and recovery using a scripted imagery paradigm in female PTSD positive physical and sexual assault survivors (N = 41) …

The Relationship Between Infant-Family Routines, Number Of Caregivers And Infant Basal Cortisol, Vanessa Newell, Hannah B. White

Undergraduate Research Symposium

Background: Family routines have been found to be related to child adjustment, marital satisfaction, and parenting competence (Fiese, 2002). Persistent stress, and the resulting frequent activation of the body’s stress responses, can result in excessive wear-and-tear on the body and brain known as allostatic load (McEwen, 2000). In infants, basal cortisol levels act as an instrument to measure allostatic load (White, 2020). To our knowledge, no existing work on the impact of routines on infant development has examined the role of family structure. In traditional and minority cultures it is common for caregiving responsibilities to be divided among multiple individuals. …

Regulation Of Self-Love, Kruti Surti

Dissertations

While the concept of self-love is well-known in today’s society, it remains unknown how self-love can be increased. Increasing self-love may help individuals decrease stress and promote well-being. The current study tested how self-love and pleasantness can be increased and whether anxiety levels and personality traits such as neuroticism and conscientiousness are associated with self-love increase. In this study, participants (N = 108; 86 women, 20 men, 1 gender queer, 1 other (not specified)) completed questionnaires related to self-compassion, self-efficacy, anxiety, and personality. Then, participants completed an online self-love regulation task in which they read prompts that encouraged them …

Bold Signal Variability Patterns In Neural Correlates Of Reflection And Brooding Components Of Rumination, Katie Leutzinger, Carissa Philippi

Undergraduate Research Symposium

Researchers have established that rumination is a debilitating symptom that positively correlates with symptoms of depression. Rumination involves self-focused attention, often negative, as a means of coping with a depressed mood or sadness. The Ruminative Responses Scale (RRS) is a tool used to measure rumination severity that includes two subsets of rumination: brooding and reflection. Brooding rumination is related to passive and judgmental thoughts about one’s circumstances and is therefore associated with higher levels of past and current depression. Although brooding is thought to be a maladaptive response to feelings of depression, past studies suggest that the reflection subtype may …

Stress, Resilience, And Impulsivity, Kendra Clark, Adam Runyan, Carissa Philippi

Undergraduate Research Symposium

Stress is a phenomenon that everyone will experience. Stress that is unmanageable can become chronic, which is linked to various negative psychological effects (Le Fevre, Matheny, & Kolt, 2003). Although stress research often focuses on the negative long-term effects, there are times where individuals develop a trait known as resilience. Resilient individuals eventually learn how to buffer the negative effects of stress (Cicchetti, 2010), and researchers have begun investigating the positive effects of resilience on stress (Cicchetti, 2010; Kermott, Johnson, Sood, R., Jenkins, & Sood, A., 2019). Currently, few studies have been conducted to identify any additional traits that may …

Chronic Stress In Relation To Locus Of Control, Kendra Clark, Miranda Jany, Carissa Philippi

Undergraduate Research Symposium

Stress is prominent in everyone’s lives, and if the right precautions are not taken, stress can become chronic and harmful to an individual’s health (Schmitz, Neumann, & Oppermann, 2000). To prevent chronic stress, researchers seek to find out important factors that lead to chronic stress. One of the most prominent factors leading to chronic stress is locus of control (LOC), or how much control people feel they have over situations (Cummins, 1988). People can endorse an internal locus of control which means individual attributes events occurring in their life to their own behavior, or an external, which one would consider …

Neurobiological Mechanisms Of Cognitive Processing Therapy For Post-Traumatic Stress Disorder: A Brain Network Approach, Tessa Vuper

Dissertations

Psychotherapy research is increasingly targeting both psychological and neurobiological mechanisms of therapeutic change. This trend is evident in and applicable to post-traumatic stress disorder (PTSD) treatment research given the high nonresponse rate of individuals with PTSD who undergo cognitive-behavioral therapy (CBT). A review of the literature investigating neurobiological mechanisms of CBT in PTSD reveals inconsistent results that fail to fully support dual process or learning models of CBT effects in the brain. However, network-based models of psychopathology provide a new framework from which to understand both mental disorder symptoms and therapeutic mechanisms. The current study investigated a) whether brain networks …

Sedative And Neurotoxic Properties Of Brexanolone Compared To Midazolam In The Developing Rodent Brain, Jacob Huffman

Dissertations

The developing brain is susceptible to extensive neurotoxicity following exposure to sedative/anesthetic drugs (SADs). Every year hundreds of thousands of children around the world are exposed to SADs with no viable non-neurotoxic agents approved for clinical use. Allopregnanolone (AlloP) has well-established sedative effects in adults and neonates. AlloP and many SADs produce sedation/anesthesia through allosteric modulation of GABA_A receptors, which is one of two principal mechanisms behind SAD-induced neurotoxicity. Evidence suggests AlloP has the unique capacity to regulate key apoptotic factors in adults and is widely involved with critical stages of neurodevelopment, indicating this neurosteroid might serve as a …

Influences Of Salvinorin A And Sex Differences On Depressive- And Anxiety-Like Behaviors In A Chronic Mild Stress Paradigm, Sarah Mitchell

Theses

Kappa opioid receptors are colocalized with dopamine receptors and are frequently associated with depression, anxiety, stress, and drug use and abuse. KOR antagonism has widely been considered anti-depressive and anxiolytic in animal models while agonism is pro-depressive and anxiogenic. However, recent findings suggest that SalvA, a natural kappa agonist derived from a plant in the mint family, can reduce depressive- and anxiety-like behavior in rats. The current study investigated the effects of chronic mild stress on behavior, attenuation by SalvA, and sex differences. 52 Long-Evans rats, 26 males and 26 females, were exposed to six weeks of CMS. Animals received …

The Vulnerability Of Chronic Stress: Implications For Feeling Like Giving Up, Miranda Jany

Theses

The feeling of learned helplessness has been associated with prolonged stress and trauma. Additionally, many previous studies have examined the relationship between stress and decreased feelings of control, such as self-efficacy and locus of control. However, these forms of control have been primarily self-reported. The present study aimed to investigate the relationships among learned helplessness, chronic stressors, and self-agency using a computer-based task. We also measured heart rate variability (HRV) during the self-agency task to assess psychophysiological correlates of these variables. Seventy-four participants completed a series of questionnaires that were used to assess lifelong stressors (e.g., exposure to natural disasters, …

Meaning In The Noise: Neural Signal Variability In Major Depressive Disorder, Sally M. Pessin

Theses

Clinical research has revealed aberrant activity and connectivity in default mode (DMN), frontoparietal (FPN), and salience (SN) network regions in major depressive disorder (MDD). Recent functional magnetic resonance imaging (fMRI) studies suggest that variability in brain activity, or blood oxygen level-dependent (BOLD) signal variability, may be an important novel predictor of psychopathology. However, to our knowledge, no studies have yet determined the relationship between resting-state BOLD signal variability and MDD nor applied BOLD signal variability features to the classification of MDD history using machine learning (ML). Thus, the current study had three aims: (i) to investigate the differences …

More Than Just Words On A Screen: A Biopsychosocial Approach To Understanding Effects Of Race-Related Media, Melinda Kittleman

Dissertations

Racial disparities in physical and mental health are ongoing and well-documented problems in the United States. Black Americans, compared to White Americans, have higher risk of obesity, heart disease, cancer, depression, and substance abuse. Research suggests prejudice and discrimination play a role in racial health disparities. Everyday discrimination is considered a chronic, psychosocial stressor that impacts the health of Black Americans. A biopsychosocial approach states there are various factors that contribute to the pathway from discrimination to disease and proposes complex relationships that explain effects of racial discrimination on health. The current study examined social factors (race-related media), biological factors …

Validation Of The Barkley Deficits Of Executive Functioning Scale-Short Form, Brian Sheble

Dissertations

The Barkley Deficits of Executive Functioning-Short Form (BDEFS-SF) is a short rating scale measuring executive functioning in adults. The BDEFS-SF was developed using the 5 highest loading questions from the BDEFS-LF. Consequently, the psychometric qualities of the BDEFS-SF were not investigated using formal methods. In this study, the psychometric attributes of the BDEFS-SF were examined using two separate but similar groups. The first group of 264 men and women aged 18-35 years old completed the BDEFS-SF via an internet survey. The second group of 36 men and women aged 18-35 years old completed the BDEFS-SF and individualized assessments of executive …

Neuroimaging And Cognitive Outcomes In Adults With Human Immunodeficiency Virus And Early Life Stress, Laurie M. Baker

Dissertations

Brain abnormalities persist in individuals with human immunodeficiency virus (HIV) despite the use of highly active antiretroviral therapy (HAART). To date, limited work has focused on the association between early life stress (ELS) and brain integrity in individuals with HIV, although ELS is highly prevalent in this population. The present study was conducted to determine whether ELS corresponds to the expression of persistent HIV–related neuroimaging abnormalities and cognitive dysfunction. A total of 130 HIV+ individuals on HAART and 76 HIV– individuals underwent 3T structural magnetic resonance imaging, diffusion tensor imaging, and neuropsychological assessment. Individuals were free of major psychiatric illness …