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Full-Text Articles in Biological Psychology
Cognitive Differences In Parkinson’S Disease With Amyloid Positivity And Negativity, Kenya Luna
Cognitive Differences In Parkinson’S Disease With Amyloid Positivity And Negativity, Kenya Luna
Electronic Theses, Projects, and Dissertations
In Parkinson’s Disease (PD), research has shifted to investigate how biomarkers commonly seen in Alzheimer’s Disease (AD), such as amyloid beta (AB), may be associated with cognitive functioning in PD. AB is considered a reliable biomarker for AD pathology, however in PD there is a lacking biomarker that can accurately reflect severity of cognitive impairment. AD research has shown an association between low AB and cognitive decline, but the data in PD has mixed results. Most studies that analyze cognitive decline and biomarkers do not use a cutoff level and the few that do have a threshold vary greatly in …
Cerebrospinal Fluid Biomarkers Not Associated With Neurologic Compromise Among Mild Cognitively Impaired Reverters With Parkinson's Disease, Cameron Ryczek
Cerebrospinal Fluid Biomarkers Not Associated With Neurologic Compromise Among Mild Cognitively Impaired Reverters With Parkinson's Disease, Cameron Ryczek
Electronic Theses, Projects, and Dissertations
Parkinson's Disease (PD) is a neurodegenerative disease characterized by motor (e.g. tremors) and non-motor symptoms (e.g. cognitive impairment). PD patients' change in cognitive functioning can be observed using the following classifications: cognitively intact, mild cognitive impairment (MCI), or dementia (PDD). MCI has many subtypes, one of which is MCI reversion which is defined as those with MCI at one time point reverting to cognitively intact later. While there is limited research into the utility of MCI reversion and its relationship with cerebrospinal fluid (CSF) biomarkers in PD, this study will begin to elucidate this relationship. To this end, data from …