Biological Psychology Commons^™

Developing Constructs For Psychopathology Research: Research Domain Criteria, Charles A. Sanislow, Daniel S. Pine, Kevin J. Quinn, Michael J. Kozak, Marjorie A. Garvey, Robert K. Heinssen, Philip Sung-En Wang, Bruce N. Cuthbert

Charles A. Sanislow, Ph.D.

There exists a divide between findings from integrative neuroscience and clinical research focused on mechanisms of psychopathology. Specifically, a clear correspondence does not emerge between clusters of complex clinical symptoms and dysregulated neurobiological systems, with many apparent redundancies. For instance, many mental disorders involve multiple disruptions in putative mechanistic factors (e.g., excessive fear, deficient impulse control), and different disrupted mechanisms appear to play major roles in many disorders. The Research Domain Criteria (RDoC) framework is a heuristic to facilitate the incorporation of behavioral neuroscience in the study of psychopathology. Such integration might be achieved by shifting the central research focus …

Taking Charge Of Adult Adhd, P. S. Mcmillen

Library Faculty Publications

Barkley is one of the leading researchers and most prolific writers on attention deficit/hyperactivity disorder (ADHD) across the life span, having produced materials for mental health professionals and self-help books like this volume.

Effect Of Depression On Attention Via Mood Induction In A Healthy Population, Cheryl Mae Calvano

Loma Linda University Electronic Theses, Dissertations & Projects

This project continues research into the cognitive attention of persons with a sad mood similar to that experienced by dysthymia. The project utilizes the Dot Probe Task to evaluate attention to affective stimuli presented in the International Affective Picture Set (IAPS). Participants were psychology students recruited from La Sierra University. Participants completed a word task that intended to induce a sad or neutral mood. The Positive and Negative Affect Scale (PANAS) was used to evaluate the efficacy of the mood induction. Overall, participant’s negative PANAS scale did not differ between groups. Groups differed between administrations of the PANAS on the …

Immune Function And Health Outcomes In Women With Depression, Cherie Howk, Mary P. Bennett

Nursing Faculty Publications

This research reports immune function and health outcomes in women with depression, as compared with a nondepressed control group. Using Psychoneuroimmunolgy theory and a descriptive comparison design, scores on the Beck Depression Inventory (BDI) were used to divide 40 non-hospitalized Caucasian women between the ages of 18 and 65 years into either the control or depression comparison group. Women with depression were found to report significantly more incidences of illness over the previous two months and they were found to have significantly more indicators of illness at the time of the exam as compared to the controls. However, contrary to …

Methodological Considerations For Treatment Trials For Persons With Borderline Personality Disorder, Mary C. Zanarini, Barbara Stanley, Donald W. Black, John C. Markowitz, Marianne Goodman, Paul Pilkonis, Thomas R. Lynch, Kenneth Levy, Peter Fonagy, Martin Bohus, Joan Farrell, Charles A. Sanislow

Charles A. Sanislow, Ph.D.

BACKGROUND: The National Institute of Mental Health convened an international group of experts to examine the conduct of treatment trials for persons with borderline personality disorder (BPD). The rapid growth of treatment research had led to the recognition that investigators face unique methodological issues with these challenging patients.

METHODS: Conference members reviewed critical aspects of psychotherapy and pharmacotherapy trial design for patients with BPD.

RESULTS: This article summarizes discussions held on March 17-18, 2005.

CONCLUSION: This paper addresses the most pressing issues in sample selection and trial design pertaining to BPD; issues that have bedeviled both investigators submitting applications and …

Cognitive And Psychiatric Predictors To Psychosis In Velocardiofacial Syndrome: A 3-Year Follow-Up Study, Kevin M. Antshel, Robert J. Shprintzen, Wanda Fremont, Anne Marie Higgins, Stephen V. Faraone, Wendy R. Kates

Communication Disorders Faculty Publications

Objective: To predict prodromal psychosis in adolescents with velocardiofacial syndrome (VCFS). Method: 70 youth with VCFS, 27 siblings of youth with VCFS and 25 community controls were followed from childhood (Mean age = 11.8 years) into mid-adolescence (mean age 15.0 years). Psychological tests measuring intelligence, academic achievement, learning/memory, attention and executive functioning as well as measures of parent and clinician ratings of child psychiatric functioning were completed at both time point. Results: Major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder diagnoses increased in the VCFS sample. With very low false positive rates, the best predictor of adolescent prodromal …

Markers Of Marijuana Use Outcomes Within Adolescent Substance Abuse Group Treatment, Paul Amrhein, Brett Engle, Mark Macgowan, Eric Wagner

Department of Psychology Faculty Scholarship and Creative Works

Objectives: Despite their popularity, little is known about what distinguishes effective from ineffective or even iatrogenic adolescent group interventions. Methods: Audio recordings and transcripts from 19, 8—10 session, school-based treatment groups comprised of 108, substance abusing 10- to 19-year olds were analyzed. Group leader empathy was measured globally, while two new constructs, group commitment, and peer response, were measured using discourse analysis. All variables were measured at the group level. Results: Associations among these process variables were tested and supported, as were the hypothesized associations between both group member language constructs and marijuana use outcomes. Conclusions: These findings were consistent …

Epigenetics: Blurring The Line Between Nature And Nurture, Elizabeth H. Rose

CMC Senior Theses

This long-standing nature versus nurture debate is cited in behavioral and physical expressions of disease dysfunctions, resiliencies, and recovery. Their purposes are noted both in scientific pursuits as well as literature. This discourse has been particularly intense in the fields of psychology, psychiatry, and biology where there is a long history of scientists’ attempts to disprove or discredit others’ intellectual and professional measures. Interestingly, recent advances in the neurosciences and genetic technologies have brought these fields closer together with a new focus – the interactional relationship between nature and nurture – epigenetics.

Illness Uncertainty, Ways Of Coping, And Psychological Adjustment Among 18--25-Year-Olds With Anaphylactic Food Allergy, Susan J. Cohen

Walden Dissertations and Doctoral Studies

The prevalence of food allergy is increasing, with adolescents and young adults being the group most likely to die from food-induced anaphylaxis. Behavioral and psychological factors contribute to this risk. This study investigated the relationship between illness uncertainty (as measured by the Mishel Uncertainty in Illness Scale Community Form) and emotion- and problem-focused coping (as measured by the Ways of Coping Scale), to see if they contributed to psychological adjustment (as measured by the Depression Anxiety Stress Scale-21) in this population. A cognitive diathesis-stress model was used to explain individual differences in adjustment. Multiple regression was used to test illness …

Using A Structured Decision Making Protocol To Stratify Caseloads In The Child Support Program, Steven J. Golightly

Walden Dissertations and Doctoral Studies

Although structured decision making and risk assessment protocols have successfully been used in human service programs, little research has been done on their applicability in the child support program. In this study, problems identified with child support case management were examined, along with positive and negative attributes of various risk assessment tools utilized in other arenas. The overall research problem asserted that there are no structured decision making protocols in the child support program to support case assignment by enforcement difficulty. The primary research question asked whether or not a process stratified by risk and level of enforcement difficulty could …

A Phenomenological Inquiry Of Chronic Homeless Individuals' Challenges To Independence, Dewana Hall

Walden Dissertations and Doctoral Studies

Homelessness is a comprehensive social problem affecting approximately 744,000 people in the U.S. Despite consistent efforts from politicians, state and local leaders, and service providers, the number of homeless people continues to rise. Although there are some explanations in the literature to account for the increase of homelessness, the literature tends to not include the voices of the homeless themselves. The purpose of this phenomenological study, which used Maslow's hierarchy of needs as its conceptual framework, was to understand the life experiences of members of the homeless population, as perceived by four male residents of a mission in an eastern …

Comparison Of Affective Analgesia And Conditioned Place Preference Following Cholinergic Activation Of, Elena Schifirnet

Wayne State University Dissertations

Activation of the dopaminergic mesolimbic reward circuitry that originates in the ventral tegmental area (VTA) is postulated to preferentially suppress affective reactions to noxious stimuli (affective analgesia, AA). VTA dopamine neurons are activated via cholinergic inputs, and we have observed that microinjections of the acetylcholine agonist carbachol suppressed vocalizations of rats that occur following administration of brief (1 sec) tail-shocks (vocalization afterdischarges = VAD). VADs are a validated rodent model of pain affect. In addition, the capacity of carbachol to support reinforcement appears to be regionally dependent within VTA. Ikemoto and Wise (2002) reported that carbachol was self-administered in the …

Functionality, Parsimony, Discovery, Avoiding Hamartia: How Evolutionary Perspectives Are Changing Psychology, Brooke N. Jenkins, Aaron T. Goetz

Psychology Faculty Articles and Research

Evolutionary psychology offers an important perspective to scientific psychology. Evolutionary psychology, in its short existence, has added an abundance of knowledge to the social sciences, let alone psychology. The study of human cognition and behavior remains incomplete without an evolutionary perspective. Here, we argue that evolutionary psychology uniquely provides a complete understanding of scientific psychology because it explains the functions of our psychological traits, provides us with the most parsimonious explanation of many psychological phenomena, predicts undocumented phenomena, and possibly allows us to avoid the downfalls of some of our contemptible evolved psychological mechanisms.

Research Domain Criteria (Rdoc): Toward A New Classification Framework For Research On Mental Disorders, Thomas R. Insel, Bruce N. Cuthbert, Marjorie A. Garvey, Robert K. Heinssen, Daniel S. Pine, Kevin J. Quinn, Charles A. Sanislow, Philip S. Wang

Charles A. Sanislow, Ph.D.

Current versions of the DSM and ICD have facilitated reliable clinical diagnosis and research. However, problems have increasingly been documented over the past several years, both in clinical and research arenas (e.g., 1, 2). Diagnostic categories based on clinical consensus fail to align with findings emerging from clinical neuroscience and genetics. The boundaries of these categories have not been predictive of treatment response. And, perhaps most important, these categories, based upon presenting signs and symptoms, may not capture fundamental underlying mechanisms of dysfunction. One consequence has been to slow the development of new treatments targeted to underlying pathophysiological mechanisms.