Biological Psychology Commons^™

Black Hearts Matter: A Comparative Study Of Sociodemographic, Clinical, And Psychosocial Characteristics In Black And White Persons With Heart Failure, Hannah M Anderson Hughes

Theses and Dissertations

Heart failure (HF) is a chronic, progressive, debilitating illness that disproportionately affects Black individuals, often leading to poor quality of life (QOL). Various sociodemographic, clinical, and psychological characteristics are related to QOL in patients with HF. Because most studies do not include representative Black samples or report findings from racial subgroup analyses, these relationships and any existing racial differences are not well understood. The purpose of this descriptive, comparative study was to explore the relationships among sociodemographic, clinical, and psychological characteristics and QOL in patients with HF and to determine if there were racial differences between Black and White individuals. …

Transcriptomic Profiling Of Postmortem Prefrontal Cortex And Nucleus Accumbens From Chronic Alcohol Abusers., Eric S. Vornholt

Theses and Dissertations

Alcohol use disorder (AUD) is a debilitating psychiatric illness that develops from a combination of genetic and environmental factors. While it is well documented that AUD is heritable, the shift from recreational alcohol use to abuse/dependence is poorly understood. In this dissertation, using postmortem brain tissue from individuals with alcohol dependence (AD), we profiled the genome-wide expression of circular RNA (circRNA), microRNA (miRNA), and messenger RNA (mRNA) to better understand the impact of gene expression on the development of AUD. To achieve this, we performed two independent studies that explore transcriptome differences between AD cases and controls. The first of …

Buffering Of Physiological And Affective Reactivity By A Single Proactive 5-Minute Stress Management Technique, Kayla Talia Johnson

Theses and Dissertations

A plethora of recent research highlights the long-term chronic disease risks of elevated blood pressure (BP), heart rate (HR) and affective and cognitive responses to mental stressors and how traditional forms of mindfulness meditation (MM) and progressive muscle relaxation (PMR) may help offset these long-term risks. On top of that, briefer forms of MM (e.g., 3-day training sessions) have shown benefits for emotional and physical health. Further, perseverative cognitions, or the tendency to worry and rumination about stressful events, is linked with heightened CV reactivity, and may impede the success of stress management techniques. The purpose of this study was …

Buffering Of Physiological And Affective Reactivity By A Single Proactive 5-Minute Stress Management Technique, Kayla Talia Johnson

Theses and Dissertations

A plethora of recent research highlights the long-term chronic disease risks of elevated blood pressure (BP), heart rate (HR) and affective and cognitive responses to mental stressors and how traditional forms of mindfulness meditation (MM) and progressive muscle relaxation (PMR) may help offset these long-term risks. On top of that, briefer forms of MM (e.g., 3-day training sessions) have shown benefits for emotional and physical health. Further, perseverative cognitions, or the tendency to worry and rumination about stressful events, is linked with heightened CV reactivity, and may impede the success of stress management techniques. The purpose of this study was …

Genome-Wide Systems Genetics Of Alcohol Consumption And Dependence, Kristin Mignogna

Theses and Dissertations

Widely effective treatment for alcohol use disorder is not yet available, because the exact biological mechanisms that underlie this disorder are not completely understood. One way to gain a better understanding of these mechanisms is to examine the genetic frameworks that contribute to the risk for developing this disorder. This dissertation examines genetic association data in combination with gene expression networks in the brain to identify functional groups of genes associated with alcohol consumption and dependence.

The first study took advantage of the behavioral complexity of human samples, and experimental capabilities provided by mouse models, by co-analyzing gene expression networks …

Shared Genetic And Environmental Influences On Fear, Anxiety, Posttraumatic Stress, And Brain Morphometry, Chelsea Sawyers

Theses and Dissertations

Anxiety disorders (ADs) and stress-related disorders are some of the most common psychiatric disorders in the United States. Like other c0mplex psychiatric illness, genetics and neuroimaging research has focused on understanding their underlying neurobiology. Areas within the fear-network play important roles in threat perception, fear conditioning/learning, cognitive processing, and modulation of fear responses including contextual modulation and extinction and have been implicated in ADs as well as stress disorders such as posttraumatic stress disorder (PTSD). The primary gap in the current search for underlying biological mechanisms is in whether biomarkers associated with disorders share genetic influences with the disorders they …

Effects Of Dietary Preference On The Experience Of Anxiety, Depression And Acute Stress Response, Shaun Stearns

Theses and Dissertations

Research has demonstrated that high saturated fat and low carbohydrate consumption may provide physiological benefit in the treatment of major neurological disorders, though not much research has explored if these benefits extend to the experience of anxiety, depression, stress and physical symptoms. The purpose of this study was to explore the relationship between fat consumption and negative emotional/physiological states (anxiety, depression, stress and physical symptoms). This study also explored how fat consumption can alter one's response to an acute stress. Participants completed an online survey indicating their food preferences and their responses to a number of self-report scales such as …