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Full-Text Articles in Biological Psychology
Discriminative Stimulus Effects Of Cannabidiol Oil In Rats, Rebecca L. Chalme
Discriminative Stimulus Effects Of Cannabidiol Oil In Rats, Rebecca L. Chalme
Graduate Theses, Dissertations, and Problem Reports
Cannabidiol (CBD) is one of the major centrally active phytocannabinoid components of cannabis, and has been approved by the FDA only for the treatment of two rare seizure disorders. However, CBD has been touted as a potential treatment for anxiety in place of more traditional treatments like benzodiazepines. Although there is some evidence of anxiolytic effects of CBD, its suitability as a substitute for benzodiazepines is unknown. This experiment was designed to assess to what extent CBD shares interoceptive discriminative-stimulus properties with the anxiolytic chlordiazepoxide (CDP), a benzodiazepine. In the present experiment, a range of doses (0-333.3 mg/kg) of over-the-counter …
A Bittersweet Investigation Of Availability And Nutritive Value As Determinants Of Volitional Sucrose Consumption, Milan D. Valyear
A Bittersweet Investigation Of Availability And Nutritive Value As Determinants Of Volitional Sucrose Consumption, Milan D. Valyear
Theses and Dissertations (Comprehensive)
Rats given ~24 h access to a 4% sucrose solution every 3rd day (E3DA) consume about 100 g more solution than rats with continuous, everyday access (EDA). Under the same EDA-E3DA conditions rats will consume similar amounts of a more concentrated 8 or 16% sucrose solutions (Eikelboom, Hewitt, & Adams, Unpublished). It maybe that with these more concentrated solutions rats hit a satiety limit that prevents a difference between EDA and E3DA consumption from being evident. Experiment 1 was conducted to investigate the effect of adding quinine to 4% and 8% sucrose solutions with the intention of reducing consumption …