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Full-Text Articles in Biological Psychology
Serotonin 1a Receptor Modulation On Behavioral Flexibility In Btbr And C57bl/6j Mice, Cassandra Cavazos
Serotonin 1a Receptor Modulation On Behavioral Flexibility In Btbr And C57bl/6j Mice, Cassandra Cavazos
Electronic Theses, Projects, and Dissertations
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by a subset of symptoms known as restricted repetitive behaviors (RRBs). RRBs are categorized into both lower order and higher order RRBs, where the latter can be described as behavioral inflexibility. The BTBR T+ tf/J (BTBR) mouse strain has been an extensively used animal model that demonstrate the behavioral symptoms of these individuals, including inflexible behavior. Currently, there are few effective treatments for individuals with ASD that express RRBs. Past research has investigated treatments that target serotonin due its historic involvement in ASD. 8-OH-DPAT (8-hydroxy-2-(di-n-propylamine) tetralin) is a research …
The Role Of 5-Ht6 Receptor Activation In Learning Consolidation, Jasmine Alyssa Robinson
The Role Of 5-Ht6 Receptor Activation In Learning Consolidation, Jasmine Alyssa Robinson
Electronic Theses, Projects, and Dissertations
The focus on serotonergic dysfunction as a contributor to cognitive deficits in disorders such as autism spectrum disorder, Alzheimer's disease, and schizophrenia drives researchers to investigate the functional impact of specific serotonin receptor types on executive functioning. By discerning the potential enhancement or impairment effects, this endeavor seeks to unravel the complex interplay between serotonin receptors and cognitive abilities. Specifically, within the three domains of learning, acquisition, consolidation, and retrieval, we find serotonergic modulation to be pivotal. Recent studies have highlighted the 5-HT6 receptor as a novel target for cognitive enhancement. However, the majority of the research investigates the effects …