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Full-Text Articles in Biological Psychology
Impact Of Perinatal Escitalopram Exposure On Adolescent Behavior, Jessica Bezenah - Bottorff
Impact Of Perinatal Escitalopram Exposure On Adolescent Behavior, Jessica Bezenah - Bottorff
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Escitalopram (EST), a selective serotonin reuptake inhibitor (SSRI), is an antidepressant frequently used during pregnancy, yet there is limited knowledge of its long-term effects on maternal use. Past studies suggest that maternal exposure may adversely affect the fetus, which may be due to the hyperserotonergic environment caused by the nature of SSRIs during early development. Modifications of the serotonergic system in offspring during certain critical periods of development may result in long-term behavioral and cognitive changes in adulthood. Further, recent human studies have demonstrated that prenatal exposure to SSRIs in humans may increase susceptibility to autism spectrum disorder (ASD) and …
Repeated Treatment With 5-Ht1a And 5-Ht1b Receptor Agonists: Evidence Of Tolerance And Behavioral Sensitization, Jordan Taylor
Repeated Treatment With 5-Ht1a And 5-Ht1b Receptor Agonists: Evidence Of Tolerance And Behavioral Sensitization, Jordan Taylor
Electronic Theses, Projects, and Dissertations
Serotonin has been found to regulate several cognitive and physiological functions, and its role in depression and other neuropsychiatric disorders has been a focus of research. More specifically, a wealth of research regarding serotonin focuses on serotonergic medications in the treatment of neuropsychiatric disorders, such as depression and anxiety, and stimulates the 5-HT1A and 5-HT1B receptors. Within the last decade, there has been an increase in prescriptions of psychotropic medication for children, however, the efficacy and adverse effects of these drugs have not been evaluated in younger populations. While antidepressants reduce symptoms of depression in adults, they are …
Effects Of Nicotine Exposure On Methamphetamine Oral Self-Administration, Extinction, And Reinstatement In Adolescent Rats, Zachary Robert Harmony
Effects Of Nicotine Exposure On Methamphetamine Oral Self-Administration, Extinction, And Reinstatement In Adolescent Rats, Zachary Robert Harmony
Electronic Theses, Projects, and Dissertations
Adolescence is a vulnerable developmental period in regards to drug initiation and use. The gateway hypothesis suggests that adolescent cigarette smoking may result in a heightened risk for methamphetamine use. However, little is understood about the role of nicotine on adolescent methamphetamine addiction. The aim of the present study was to determine whether early, late, or continuous adolescent nicotine exposure would alter oral methamphetamine self-administration, extinction, or reinstatement. A total of 164 male and female Sprague-Dawley rats were pretreated with saline or nicotine (0.16, or 0.64 mg/kg, sc) beginning on postnatal day (PD) 25 for 10 consecutive days. On PD …