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Articles 301 - 330 of 860
Full-Text Articles in Psychology
Maladaptive Personality Traits And Health Behaviors, Health Perceptions, And Inflammatory Biomarkers In Older Adults, Joshua R. Oltmanns
Maladaptive Personality Traits And Health Behaviors, Health Perceptions, And Inflammatory Biomarkers In Older Adults, Joshua R. Oltmanns
Theses and Dissertations--Psychology
Traits from dimensional models of normal-range personality have been shown to predict physical health outcomes including health behaviors, health perceptions, disease, and mortality. Maladaptive traits of personality disorders may predict even more variance in physical health indicators. Dimensional models of maladaptive personality traits are replacing categorical models of personality disorder, and the five-factor model of personality disorder (FFMPD) has been shown to be a useful dimensional model of maladaptive traits. However, there has been little work investigating the criterion validity of the FFMPD for predicting physical health indicators. The present study examines FFMPD scales in the prediction of health behaviors, …
Intentional Personality Change: Toward The Prevention Of Problem Drinking, Elizabeth N. Riley
Intentional Personality Change: Toward The Prevention Of Problem Drinking, Elizabeth N. Riley
Theses and Dissertations--Psychology
Personality stability across the lifespan has been well documented, but within that overall stability there is also evidence of meaningful change. There is both theoretical and empirical evidence to suggest that personality change can occur at the volition of the individual, through behavioral processes. The current study tested whether an emotion modulation intervention that promoted behavior change could be applied to reduce a related, high-risk personality trait (negative urgency) and a high-risk behavior (heavy alcohol consumption) using a three-week long, mixed laboratory design. Participants (n=23) were a sample of heavy drinking but otherwise healthy volunteers who were randomly assigned to …
Influences Among Affect Based Risk Factors And Problem Drinking In College Students, Emily Atkinson
Influences Among Affect Based Risk Factors And Problem Drinking In College Students, Emily Atkinson
Theses and Dissertations--Psychology
Broad negative affect has been consistently shown to predict problematic alcohol use. More specific affect-based constructs, though, have been shown to predict problem drinking above and beyond broad negative affectivity. The current study aims to investigate transactions among and predictive roles of broad negative affectivity and specific affective-based factors in relation to problem drinking among a sample of 358 students assessed twice during their first year of college. Participants were assessed for negative urgency (the tendency to act rashly when highly emotional), affective lability (the tendency to experience rapid and intense shifts in mood), negative affectivity, and problem drinking via …
The Role Of Attachment And Cognitive Pre-Sleep Arousal On Associations Between Sleep Concordance And Sleep Quality, Taylor L. Elsey
The Role Of Attachment And Cognitive Pre-Sleep Arousal On Associations Between Sleep Concordance And Sleep Quality, Taylor L. Elsey
Theses and Dissertations--Psychology
The amount of time someone spends co-sleeping with their partner, known as sleep concordance, has implications for sleep quality in couples. Attachment security has emerged as an important moderator of the association between sleep concordance and subjective sleep quality (Elsey et al., 2019). The current study tested whether cognitive pre-sleep arousal explains this pattern of moderation. Prior research suggests that these associations between sleep concordance, attachment security, and subjective sleep quality may be stronger for women than men, therefore gender differences in associations were also examined. Participants were 204 (68% female) individuals in an exclusive relationship lasting at least 3 …
Examining The Impact Of Social Media Use On Body Dissatisfaction And Eating Disorder Symptomatology Among Adolescents, Ilyssa P. Salomon
Examining The Impact Of Social Media Use On Body Dissatisfaction And Eating Disorder Symptomatology Among Adolescents, Ilyssa P. Salomon
Theses and Dissertations--Psychology
Media exposure is often cited as a causal factor in the development of body dissatisfaction, or negative thoughts and feelings toward the body (Grogan, 2017; Thompson, Heinberg, Atlabe, & Tantleff-Dunn, 1999). While eating disorders most commonly emerge during late adolescence (18-21 years), risk factors that predict the later onset of eating disorders emerge much earlier and escalate during adolescence (13-16 years; Hudson, Hiripi, Pope, & Kessler, 2007; Rhode, Stice, & Marti, 2016). Overall, links between exposure to traditional forms of mainstream media (e.g. television and magazines), body dissatisfaction, and eating disorder symptomatology are well- established in the literature, with robust …
Advancing The Measurement Of Trauma-Related Shame Among Women With Histories Of Interpersonal Violence, Alyssa Jones
Advancing The Measurement Of Trauma-Related Shame Among Women With Histories Of Interpersonal Violence, Alyssa Jones
Theses and Dissertations--Psychology
Shame is a predominant emotion for some trauma-exposed individuals—particularly survivors of interpersonal violence (IPV)—that is associated with more severe symptoms of posttraumatic stress disorder (PTSD; see Saraiya & Lopez-Castro, 2016). Despite growing evidence of shame’s importance in recovery from trauma and PTSD, measurement challenges have played a large role in difficulties understanding and comparing the impact of shame across studies. These challenges include: 1) the use of measures that assess trait shame as opposed to trauma-related shame, 2) inconsistent use of established shame measures across studies, and 3) failure to acknowledge the co-occurrence of shame and guilt. These limitations are …
Elementary School Children’S Understanding Of Disproportionate Discipline, Sharla D. Biefeld
Elementary School Children’S Understanding Of Disproportionate Discipline, Sharla D. Biefeld
Theses and Dissertations--Psychology
In the U.S. Black students, particularly Black boys, receive more out of school punishments, are punished more frequently, and are punished for more subjective behaviors than their White peers (Skiba, Michael, Nardo, & Peterson, 2002). This phenomenon is referred to as disproportionate discipline and is an early precursor to the disproportionate number of Black men and boys incarcerated in the U.S. Disproportionate discipline begins as early as preschool, and continues throughout elementary, middle, and high school (Gregory & Fergus, 2017). Perceptions of discrimination greatly impact children’s school involvement, school belonging, and educational outcomes (Brown, 2017, for review). However, little is …
Attentional Control In Infancy: The Role Of Sociodemographic Risk, Cortisol, And The Home Environment, Hannah B. White
Attentional Control In Infancy: The Role Of Sociodemographic Risk, Cortisol, And The Home Environment, Hannah B. White
Theses and Dissertations--Psychology
Infants’ ability to channel their cognitive resources by controlling their visual attention allows them to be active agents in their learning and development. Individual differences in attentional control have been linked to a wide variety of developmental outcomes including disparities between social classes in cognitive functioning. However, it is yet unknown when in development differences in attentional control related to sociodemographic factors emerge, or how factors of the home environment and the infant’s stress response relate to this effect. Accordingly, Experiment 1 examined whether certain sociodemographic factors, such as socioeconomic and minority status, predict 3.5-month-old infants’ (N = 102) …
Ethanol Sustains Phosphorylated Tau Protein Immunofluorescence In The Cultured Neonatal Rat Hippocampus: Implications For Fetal Alcohol Spectrum Disorders, Caleb Seth Bailey
Ethanol Sustains Phosphorylated Tau Protein Immunofluorescence In The Cultured Neonatal Rat Hippocampus: Implications For Fetal Alcohol Spectrum Disorders, Caleb Seth Bailey
Theses and Dissertations--Psychology
Fetal Alcohol Spectrum Disorders (FASDs) are comprised of developmental, behavioral, and cognitive abnormalities caused by prenatal alcohol exposure, affecting an estimated 2%-5% of childrenand costing up to $4 billion annually in the United States alone. Although some behavioral therapies can help, the biochemical mechanisms that underpin FASDs need further elucidation for development of more efficacious therapeutics. The tau protein modulates cytoskeletal structure in neurons, and thereby plays an integral role in proper development and function of the central nervous system, but its function is altered by its phosphorylation state, such that increased phosphorylation reduces tau protein function. The tau protein …
Structure And Demographic Correlates Of Individual Trait Responses To Emotions, Anita Adams
Structure And Demographic Correlates Of Individual Trait Responses To Emotions, Anita Adams
Theses and Dissertations--Psychology
From a functionalist perspective, emotions inform people of their needs and influence responses to the environment. Responses to emotion encompass more than emotion regulation strategies. Individual differences emerge from the consistent way that people cope with their emotions, called trait responses to emotion (TRE). We hypothesized approach/avoidance and control/dyscontrol would characterize the dimensional structure of TRE and that dimensions would correlate with age, gender, and early life experiences. The present study developed a multidimensional model to explore TRE from a TurkPrime sample (N = 284). Participants completed a web-based battery of surveys with demographic, early life experience, and TRE questionnaires. …
Co-Prescription Network Reveals Social Dynamics Of Opioid Doctor Shopping, Brea L. Perry, Kai Cheng Yang, Patrick Kaminski, Meltem Odabas, Jaehyuk Park, Michelle M. Martel, Carrie B. Oser, Patricia R. Freeman, Yong-Yeol Ahn, Jeffery C. Talbert
Co-Prescription Network Reveals Social Dynamics Of Opioid Doctor Shopping, Brea L. Perry, Kai Cheng Yang, Patrick Kaminski, Meltem Odabas, Jaehyuk Park, Michelle M. Martel, Carrie B. Oser, Patricia R. Freeman, Yong-Yeol Ahn, Jeffery C. Talbert
Psychology Faculty Publications
This paper examines network prominence in a co-prescription network as an indicator of opioid doctor shopping (i.e., fraudulent solicitation of opioids from multiple prescribers). Using longitudinal data from a large commercially insured population, we construct a network where a tie between patients is weighted by the number of shared opioid prescribers. Given prior research suggesting that doctor shopping may be a social process, we hypothesize that active doctor shoppers will occupy central structural positions in this network. We show that network prominence, operationalized using PageRank, is associated with more opioid prescriptions, higher predicted risk for dangerous morphine dosage, opioid overdose, …
Socioemotional Selectivity And Psychological Health In Amyotrophic Lateral Sclerosis Patients And Caregivers: A Longitudinal, Dyadic Analysis, Suzanne C. Segerstrom, Edward J. Kasarskis, David W. Fardo, Philip M. Westgate
Socioemotional Selectivity And Psychological Health In Amyotrophic Lateral Sclerosis Patients And Caregivers: A Longitudinal, Dyadic Analysis, Suzanne C. Segerstrom, Edward J. Kasarskis, David W. Fardo, Philip M. Westgate
Psychology Faculty Publications
Objective: Socioemotional selectivity theory predicts that as the end of life approaches, goals and resources that provide immediate, hedonic reward become more important than those that provide delayed rewards. This study tested whether these goal domains differentially affected psychological health in the context of marital dyads in which one partner had been diagnosed with amyotrophic lateral sclerosis (ALS), a life-limiting disease.
Design: ALS patients (N = 102) being treated in three multidisciplinary clinics and their spouses (N = 100) reported their loneliness, financial worry and psychological health every 3 months for up to 18 months.
Main …
Opportunities For Self-Evaluation Increase Student Calibration In An Introductory Biology Course, Jennifer L. Osterhage, Ellen Usher, Trisha A. Douin, William M. Bailey
Opportunities For Self-Evaluation Increase Student Calibration In An Introductory Biology Course, Jennifer L. Osterhage, Ellen Usher, Trisha A. Douin, William M. Bailey
Biology Faculty Publications
Accurate self-evaluation is critical for learning. Calibration describes the relationship between learners’ perception of their performance and their actual performance on a task. Here, we describe two studies aimed at assessing and improving student calibration in a first-semester introductory biology course at a 4-year public institution. Study 1 investigated students’ (n = 310) calibration (the difference between estimated and actual exam performance) across one semester. Students were significantly miscalibrated for the first exam: their predicted scores were, on average, significantly higher than their actual scores. The lowest-performing students had the most inaccurate estimates. Calibration improved with each exam. By …
The Relationship Between Psychological States And Health Perception In Individuals At Risk For Cardiovascular Disease, Kyoung Suk Lee, Frances J. Feltner, Alison L. Bailey, Terry A. Lennie, Misook L. Chung, Brittany L. Smalls, Donna L. Schuman, Debra K. Moser
The Relationship Between Psychological States And Health Perception In Individuals At Risk For Cardiovascular Disease, Kyoung Suk Lee, Frances J. Feltner, Alison L. Bailey, Terry A. Lennie, Misook L. Chung, Brittany L. Smalls, Donna L. Schuman, Debra K. Moser
Family and Community Medicine Faculty Publications
Backgrounds: Perceptions of health are important to motivate people to change behaviors. Non-adherence to healthy behaviors that prevent cardiovascular disease may result from inadequate health perceptions. However, there are few studies investigating relationships between health perceptions and psychological states.
Objective: To determine whether psychological states (ie, depressive symptoms and anxiety) are associated with the congruency between health perception and estimated risk for cardiovascular disease in adults with 2 or more cardiovascular disease risk factors.
Methods: Community dwellers at risk for cardiovascular disease were asked to complete the Patient Health Questionnaire-9 and the anxiety subscale of the Brief Symptom Inventory to …
Associations Of First Trimester Co-Use Of Tobacco And Cannabis With Prenatal Immune Response And Psychosocial Well-Being, Kristin Ashford, Amanda Fallin-Bennett, Andrea Mccubbin, Amanda T. Wiggins, Sheila Barnhart, Joshua A. Lile
Associations Of First Trimester Co-Use Of Tobacco And Cannabis With Prenatal Immune Response And Psychosocial Well-Being, Kristin Ashford, Amanda Fallin-Bennett, Andrea Mccubbin, Amanda T. Wiggins, Sheila Barnhart, Joshua A. Lile
Perinatal Research and Wellness Center Faculty Publications
PURPOSE: This study aims to describe the association of first trimester co-use of tobacco and cannabis with maternal immune response and psychosocial well-being, relative to tobacco use only.
METHODS: A preliminary midpoint analysis included 138 pregnant women with biologically verified tobacco use, 38 of whom (28%) also tested positive for recent cannabis use. Maternal perceived stress (Perceived Stress Scale), depressive symptoms (Edinburgh Postnatal Depression Scale), and serum immune markers (IL-1β, IL-2, IL-6, IL-8, IL-10, TNFα, CRP, MMP8), were collected, although cytokine data were only available for 122 women.
RESULTS: Participant average age was 29.1 years, approximately half had a high …
A Not-So Beautiful Mind: A Review Of The Genetics Of Schizophrenia, Lydia Pack
A Not-So Beautiful Mind: A Review Of The Genetics Of Schizophrenia, Lydia Pack
Oswald Research and Creativity Competition
Schizophrenia is often called “the cancer of the brain” because of the lifelong, horrendous implications of the disease. Though research has been conducted on schizophrenia for a century or more, it has just recently been realized how large a role genetics may play in the development of the disease. This review will discuss why research on schizophrenia genes has been difficult, what genes have been found, how the current treatments are being revolutionized, and how to progress in this field. The difficulty in research is due in part to the complex genetics behind the disease as well as possible environmental …
Efficient Identification Of Function: A Comparison Of Different Implementers During Functional Analyses, Katelyn E. Nicklow
Efficient Identification Of Function: A Comparison Of Different Implementers During Functional Analyses, Katelyn E. Nicklow
Theses and Dissertations--Early Childhood, Special Education, and Counselor Education
Functional analyses (FAs) are a common tool used in the assessment and treatment of severe problem behaviors and often occur in the context of clinical settings with unfamiliar, trained staff. Previous research suggests that inconsistent outcomes can emerge when caregivers with an existing history of seeing their child’s challenging behavior are trained to implement the assessment in place of clinical staff. The purpose of the current study was to expand on existing literature by comparing FA implemented by clinical staff and caregivers in the context of a clinical setting. Results demonstrate that efficient identification of function and differentiated rates of …
Defining Infidelity And Identifying Offending Spouses, Yabin Tang
Defining Infidelity And Identifying Offending Spouses, Yabin Tang
Theses and Dissertations--Family Sciences
Research on infidelity has suffered from inconsistency in how infidelity has been operationalized across studies. This study was designed to advance methodological considerations for defining infidelity and identifying offending spouses. A subjective definition of infidelity was obtained from each respondent via both closed- and open-ended items. The open-ended responses were applied to explore the definition of infidelity. Additionally, an indirect questioning method was adopted to identify offending spouses according to their own subjective definitions of cheating and test the effectiveness of this approach relative to direct questioning for identifying offending spouses. Furthermore, gender differences in acknowledging infidelity through both direct …
Effects Of Naltrexone On Alcohol And Nicotine Use In Female P Rats, Usman Z. Hamid, Sarah E. Maggio, Meredith A. Saunders, Kimberly Nixon, Mark A. Prendergast, Richard L. Bell, Michael T. Bardo
Effects Of Naltrexone On Alcohol And Nicotine Use In Female P Rats, Usman Z. Hamid, Sarah E. Maggio, Meredith A. Saunders, Kimberly Nixon, Mark A. Prendergast, Richard L. Bell, Michael T. Bardo
Posters-at-the-Capitol Presentations
The objective of the present study was to determine the effectiveness of the opioid antagonist naltrexone at reducing the consumption of EtOH and nicotine in female alcohol-preferring (P) rats. P rats have been selectively bred to have a genetic predisposition for alcohol abuse, which allows them to be used as an animal model of alcoholism. P rats readily self-administer i.v nicotine (Le et al., 2016), have EtOH consumption during adolescence that is similar to that seen in adulthood, and operantly respond for EtOH until they are impaired/intoxicated (Bell et al., 2006). Thus, P rats are a useful model for studying …
Effects Of Methamphetamine Isomers On D-Methamphetamine Self-Administration And Food-Maintained Responding In Male Rats, Michael T. Bardo, Emily D. Denehy, Lindsey R. Hammerslag, Linda P. Dwoskin, B. E. Blough, A. Landavazo, Jack Bergman, S. J. Kohut
Effects Of Methamphetamine Isomers On D-Methamphetamine Self-Administration And Food-Maintained Responding In Male Rats, Michael T. Bardo, Emily D. Denehy, Lindsey R. Hammerslag, Linda P. Dwoskin, B. E. Blough, A. Landavazo, Jack Bergman, S. J. Kohut
Psychology Faculty Publications
Rationale Methamphetamine (METH) abuse is generally attributed to the d-isomer. Self-administration of l-METH has been examined only in rhesus monkeys with a history of cocaine self-administration or drug-naïve rats using high toxic doses.
Objectives In this study, the ability of l-METH and, for comparison, d-METH to engender self-administration in experimentally naïve rats, as well as to decrease d-METH self-administration and food-maintained responding, was examined.
Methods Male Sprague-Dawley rats were used in 3 separate experiments. In experiment 1, the acquisition of l- or d-METH self-administration followed by dose-response determinations was studied. In experiment 2, rats were trained to self-administer d-METH (0.05 …
The Effects Of Parental Divorce And Remarriage On Emerging Adult’S Romantic Attachment Styles, Bailey Mortis
The Effects Of Parental Divorce And Remarriage On Emerging Adult’S Romantic Attachment Styles, Bailey Mortis
Theses and Dissertations--Family Sciences
This study shined light on the gap in literature about the impact of communication and involvement of stepparents has on emerging adult’s romantic attachment styles. A sample of 289 college students between the ages of 18 and 22 at the University of Kentucky was recruited to complete an online survey about their perceived experience with their stepparent and parental figures and the effects on their romantic attachment styles. Parental involvement in children’s lives and having good communication, sets the foundation for individuals to have secure attachment styles. Emerging adults who experience parental figures and stepparents as being uninterested or passive …
A Survey Of Providers And Patients Assessing The Need For And Use Of Prevention Practitioners To Combat Obesity In The Primary Care Setting, Amanda R. Lyons
A Survey Of Providers And Patients Assessing The Need For And Use Of Prevention Practitioners To Combat Obesity In The Primary Care Setting, Amanda R. Lyons
DNP Projects
Purpose: The overall aim of this project was to gather information from two groups of stakeholders, providers and patients, on the feasibility of implementing prevention practitioners in the primary care system to address overweight and obesity.
Methods: This study utilized a quantitative descriptive design through the use of electronic surveys. Provider surveys were explained and presented during a monthly provider meeting. Patient flyers were posted in exam rooms and surveys were accessible through a provided link and QR code.
Results: Providers (N=10) agreed that they saw a need for the use of a prevention practitioner (Mean=4.44, SD=.88) as well as …
Consumer Embarrassment – A Meta-Analytic Review And Experimental Examination, Alexander H. Ziegler
Consumer Embarrassment – A Meta-Analytic Review And Experimental Examination, Alexander H. Ziegler
Theses and Dissertations--Marketing and Supply Chain
This dissertation consists of two essays that discuss the influence of embarrassment on consumers. In the first essay, I examine consumers’ coping responses to embarrassment in a meta-analytic review. In essay two, I utilize an experimental approach to investigate the impact of embarrassing encounters on unrelated consumers who merely observe the situation.
In the first essay, the meta-analysis is guided by findings in the literature that demonstrate embarrassment can both promote and detract from consumer well-being. However, despite being investigated for decades, little is known about how consumers cope with embarrassing situations, and when and why consumers respond in positive …
Suicide Attitudes And Terror Management Theory, Athena Kheibari
Suicide Attitudes And Terror Management Theory, Athena Kheibari
Theses and Dissertations--Social Work
Virtually every mental health problem carries stigma, but suicide appears to run so counter to our accumulative, achievement-oriented society, that it poses even greater threat of stigma. While suicide is inherently troubling in that it opposes the fundamental human instinct for self-preservation, the tendency to stigmatize and reject individuals affected by suicide appears to be counterproductive and excessive. Hence, the purpose of this three-manuscript dissertation is to gain a more nuanced understanding of suicide attitudes from an exploratory and terror management theory perspective. More specifically, this dissertation attempts to answer three general questions: (1) how do suicide attitudes differ from …
A Closer Look At Internet Addiction, Jakub Mikuška
A Closer Look At Internet Addiction, Jakub Mikuška
Theses and Dissertations--Family Sciences
Based on a sample of 1,012 late adolescents and young adults (ages 18-26), the current three interrelated studies tested a series of specific questions and hypotheses focused on understanding Internet Addiction.
Study 1 sought to directly compare psychometric properties of four of the most widely used Internet addiction scales based on citation metrics (Internet Addiction Test, Problematic Internet Use Questionnaire, Generalized Problematic Internet Use Scale 2 and Chen Internet Addiction Scale), and to aggregate the best items across all scales into a new measure using bifactor IRT analyses. The resulting 10-item Aggregated Internet Addiction Scale (AIAS) consists of the best …
Caregivers Of Parents With Alzheimer’S Disease: Quality Of Life For Caregivers: Perspectives & Family Dynamics, Matthew Cornu
Caregivers Of Parents With Alzheimer’S Disease: Quality Of Life For Caregivers: Perspectives & Family Dynamics, Matthew Cornu
Theses and Dissertations--Family Sciences
This study furthers Alzheimer’s family literature regarding the impact of caregiver attachment, readiness to provide care, and caregiver quality of life. A sample of 33 participants caring for a parent with Alzheimer’s disease in the state of Kentucky was recruited to complete a questionnaire for the study. The questionnaire consisted of an online survey about participants’ experiences and attachments growing up with their parents, their experiences becoming caregivers to their parents with Alzheimer’s disease, and participants’ current perspectives of their own quality of life. Positive perspectives in regards to quality of life among caregivers seem to be a predictor of …
Beyond Telling: A Phenomenology Of Adoptive Parents' Adoption Communication Openness With Early Adolescents, Jane D. Samuel
Beyond Telling: A Phenomenology Of Adoptive Parents' Adoption Communication Openness With Early Adolescents, Jane D. Samuel
Theses and Dissertations--Family Sciences
Despite calls for increased Adoption Communication Openness (ACO) within the adoptive family, research indicates that families still struggle to accomplish the recommended elements and levels of openness. What could be holding families back from this key process? Three focus groups comprised of 17 adoptive parents of early adolescents (aged 10-14) who were age 0-2 at the time of placement were thematically coded. This inductive analysis revealed the complexity rooted in being —sometimes successfully and sometimes not—communicatively open. Four key themes emerged painting a vivid and rich picture of: a) the breadth and depth of this experience; b) the work entailed; …
Developmental Sequelae In Language, Empathy, Self-Control, And Psychopathy From Infancy To Middle Adolescence, Magda Javakhishvili
Developmental Sequelae In Language, Empathy, Self-Control, And Psychopathy From Infancy To Middle Adolescence, Magda Javakhishvili
Theses and Dissertations--Family Sciences
The present empirical work aims to discern the underlying mechanisms of purported developmental links among several key human characteristics including language skills, self-control, empathy, and psychopathic traits. Accordingly, three interrelated studies are carried out testing the longitudinal associations of various kinds (e.g., direct, indirect, bidirectional) among these constructs. All three studies are conceptually framed in consideration of the extant research and relevant theories. They employ the data set provided by the National Institute of Child Health and Human Development of Early Child Care and Youth Development Study of N = 1,364 children followed from infancy through middle adolescence.
Study 1 …
Environmental Enrichment And Drug Value: A Behavioral Economic Analysis In Male Rats, Justin R. Yates, Michael T. Bardo, Joshua S. Beckmann
Environmental Enrichment And Drug Value: A Behavioral Economic Analysis In Male Rats, Justin R. Yates, Michael T. Bardo, Joshua S. Beckmann
Psychology Faculty Publications
Rats raised in an enriched condition (EC) show decreased stimulant self-administration relative to rats reared in an isolated condition (IC). However, few studies have examined the behavioral mechanisms underlying this environment-induced difference in self-administration. Because economic demand for drugs of abuse predicts addiction-like behavior in both humans and animals, we applied a behavioral economic analysis to cocaine self-administration data in EC and IC rats. During cocaine self-administration, the dose decreased across blocks of trials (0.75–0.003 mg/kg/inf), which allowed for a determination of demand intensity and demand elasticity. Demand intensity did not differ between EC and IC rats; however, cocaine was …
Gz-11608, A Vesicular Monoamine Transporter-2 Inhibitor, Decreases The Neurochemical And Behavioral Effects Of Methamphetamine, Na-Ra Lee, Guangrong Zheng, Markos Leggas, Venumadhav Janganati, Justin R. Nickell, Peter A. Crooks, Michael T. Bardo, Linda P. Dwoskin
Gz-11608, A Vesicular Monoamine Transporter-2 Inhibitor, Decreases The Neurochemical And Behavioral Effects Of Methamphetamine, Na-Ra Lee, Guangrong Zheng, Markos Leggas, Venumadhav Janganati, Justin R. Nickell, Peter A. Crooks, Michael T. Bardo, Linda P. Dwoskin
Psychology Faculty Publications
Despite escalating methamphetamine use and high relapse rates, pharmacotherapeutics for methamphetamine use disorders are not available. Our iterative drug discovery program had found that R-N-(1,2-dihydroxypropyl)-2,6-cis-di-(4-methoxy-phenethyl)piperidine hydrochloride (GZ-793A), a selective vesicular monoamine transporter-2 (VMAT2) inhibitor, specifically decreased methamphetamine’s behavioral effects. However, GZ-793A inhibited human-ether-a-go-go-related gene (hERG) channels, suggesting cardiotoxicity and prohibiting clinical development. The current study determined if replacement of GZ-793A’s piperidine ring with a phenylalkyl group to yield S-3-(4-methoxyphenyl)-N-(1-phenylpropan-2-yl)propan-1-amine (GZ-11608) diminished hERG interaction while retaining pharmacological efficacy. VMAT2 inhibition, target selectivity, and mechanism of GZ-11608-induced inhibition of methamphetamine-evoked vesicular dopamine release were determined. We used GZ-11608 doses that decreased methamphetamine-sensitized …