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Articles 2221 - 2250 of 2919

Full-Text Articles in Psychology

Cardiovascular Fitness Associated With Cognitive Performance In Heart Failure Patients Enrolled In Cardiac Rehabilitation, Sarah Garcia, Michael L. Alosco, Mary Beth Spitznagel, Ronald Cohen, Naftali Raz, Lawrence Sweet, Richard Josephson, Joel Hughes, Jim Rosneck, Morgan L. Oberle, John Gunstad Jan 2013

Cardiovascular Fitness Associated With Cognitive Performance In Heart Failure Patients Enrolled In Cardiac Rehabilitation, Sarah Garcia, Michael L. Alosco, Mary Beth Spitznagel, Ronald Cohen, Naftali Raz, Lawrence Sweet, Richard Josephson, Joel Hughes, Jim Rosneck, Morgan L. Oberle, John Gunstad

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Reduced cognitive function is common in persons with heart failure (HF). Cardiovascular fitness is a known contributor to cognitive function in many patient populations, but has only been linked to cognition based on estimates of fitness in HF. The current study examined the relationship between fitness as measured by metabolic equivalents (METs) from a standardized stress test and cognition in persons with HF, as well as the validity of office-based predictors of fitness in this population.

Methods

Forty-one HF patients enrolled in cardiac rehabilitation completed a standardized exercise stress test protocol, a brief neuropsychological battery, the 2-minute step …


The Importance Of Female Choice: Evolutionary Perspectives On Constraints, Expressions, And Variations, David Frederick, Tania A. Reynolds, Maryanne L. Fisher Jan 2013

The Importance Of Female Choice: Evolutionary Perspectives On Constraints, Expressions, And Variations, David Frederick, Tania A. Reynolds, Maryanne L. Fisher

Psychology Faculty Books and Book Chapters

This chapter introduces the reader to some of the influential perspectives on female mate choice in human evolutionary biology, including parental investment theory. We then present two key theories in evolutionary psychology that have been applied to understand variations in women’s mating preferences and choices: sexual strategies theory and strategic pluralism theory. Although the importance of female choice has gained widespread acceptance in the biological sciences, the influence that female choice has on mating systems can be limited by many factors, such as control over mating decisions by parents and men’s control over women’s sexuality. Despite these constraints on female …


Afraid To Help: Social Anxiety Partially Mediates The Association Between 5-Httlpr Triallelic Genotype And Prosocial Behavior, Scott F. Stoltenberg, Christa C. Christ, Gustavo Carlo Jan 2013

Afraid To Help: Social Anxiety Partially Mediates The Association Between 5-Httlpr Triallelic Genotype And Prosocial Behavior, Scott F. Stoltenberg, Christa C. Christ, Gustavo Carlo

Department of Psychology: Faculty Publications

There is growing evidence that the serotonin system influences prosocial behavior. We examined whether anxiety mediated the association between variation in the serotonin transporter gene regulatory region (5-HTTLPR) and prosocial behavior. We collected self-reported tendencies to avoid certain situations and history of helping others using standard instruments and buccal cells for standard 5-HTTLPR genotyping from 398 undergraduate students. Triallelic 5-HTTLPR genotype was significantly associated with prosocial behavior and the effect was partially mediated by social anxiety, such that those carrying the S′ allele reported higher levels of social avoidance and lower rates of helping others. These results are consistent with …


The Applicability Of The Self-Fulfillment Account Of Welfare To Nonhuman Animals, Babies, And Mentally Disabled Humans, Tatjana Visak, Jonathan Balcombe Jan 2013

The Applicability Of The Self-Fulfillment Account Of Welfare To Nonhuman Animals, Babies, And Mentally Disabled Humans, Tatjana Visak, Jonathan Balcombe

Sentience Collection

In this paper we will argue that generality is a virtue of Haybron’s account of welfare. Indeed, reflecting on the applicability of his theory to nonhuman animals will give us a better understanding of its applicability to humans. We will first focus on self-fulfillment and suggest an interpretation of Haybron’s account according to which the self-fulfillment of an individual consists in the fulfillment of the aspects of the self that are applicable to that particular individual. This makes Haybron’s account of welfare applicable to all sentient beings. Then we will focus on sub-personal nature-fulfillment and argue that the same interpretation …


Great Ape Mindreading: What’S At Stake?, Kristin Andrews Jan 2013

Great Ape Mindreading: What’S At Stake?, Kristin Andrews

Ethology Collection

Humans and other great apes are similar in so many ways. We share an extended immaturity and intense infant-caregiver relationships, group living situations, cultural transmission of technology, and many emotions and cognitive capacities. Yet the communities of nonhuman apes are also very different from human communities. Humans build lasting tools, and store them to use later. We build permanent sleeping and living structures. We cook our food. We have courts of law and prisons and ethics books. There are vast technological differences between humans and nonhuman great apes. What is it that accounts for such a difference? On one account, …


Social Learning In Juvenile Lemon Sharks, Negaprion Brevirostris, Tristan L. Guttridge, Sander Van Dijk, Eize Stamhuis, Jens Krause, Samuel Gruber, Culum Brown Jan 2013

Social Learning In Juvenile Lemon Sharks, Negaprion Brevirostris, Tristan L. Guttridge, Sander Van Dijk, Eize Stamhuis, Jens Krause, Samuel Gruber, Culum Brown

Sentience Collection

Social learning is taxonomically widespread and can provide distinct behavioural advantages, such as in finding food or avoiding predators more efficiently. Although extensively studied in bony fishes, no such empirical evidence exists for cartilaginous fishes. Our aim in this study was to experimentally investigate the social learning capabilities of juvenile lemon sharks, Negaprion brevirostris. We designed a novel food task, where sharks were required to enter a start zone and subsequently make physical contact with a target in order to receive a food reward. Naive sharks were then able to interact with and observe (a) pre-trained sharks, that is, ‘demonstrators’, …


Does True Syntax Or Simple Auditory Object Support The Role Of Skylark Song Dialect?, Elodie F. Briefer, Fanny Rybak, Thierry Aubin Jan 2013

Does True Syntax Or Simple Auditory Object Support The Role Of Skylark Song Dialect?, Elodie F. Briefer, Fanny Rybak, Thierry Aubin

Sentience Collection

Parallels between birdsong and human language are numerous and include particular temporal arrangements of acoustic units and the existence of dialects. In animal communication, modifications of the temporal ordering of existing acoustic units have rarely been clearly linked with changes in information content, particularly in a natural environment. Here, we show that the organization of birdsong units (‘syllables’) in sequences supports interindividual relationships within skylark communities. We manipulated the temporal arrangement of song dialect variants (‘shared phrases’) in the skylark, Alauda arvensis, a songbird with a very large repertoire of syllables and complex song. When tested with playback experiments performed …


Assumptions In Animal Cognition Research, Kristin Andrews, Brian Huss Jan 2013

Assumptions In Animal Cognition Research, Kristin Andrews, Brian Huss

Psychology Collection

No abstract provided.


Ape Autonomy? Social Norms And Moral Agency In Other Species, Kristin Andrews Jan 2013

Ape Autonomy? Social Norms And Moral Agency In Other Species, Kristin Andrews

Autonomy Collection

No abstract provided.


Do Painful Sensations And Fear Exist In Fish?, Lynne U. Sneddon Jan 2013

Do Painful Sensations And Fear Exist In Fish?, Lynne U. Sneddon

Distress Collection

The detection of pain and fear in fi sh has been subject to much debate and, since fi sh are a popular experimental model and commercially important in both angling and aquaculture, many procedures that fi sh are subjected to cause injury, fear and stress. These injuries would give rise to the sensation of pain in humans but whether fi sh have the capacity for pain is relatively under explored. Recent evidence has shown that fi sh have the same neural apparatus to detect pain that mammals and humans do, that their brain is active during a potentially painful experience, …


Psychologists And Medications In The Era Of Interprofessional Care: Collaboration Is Less Problematic And Costly Than Prescribing, William N. Robiner, Tim R. Tumlin, Tanya Tompkins Jan 2013

Psychologists And Medications In The Era Of Interprofessional Care: Collaboration Is Less Problematic And Costly Than Prescribing, William N. Robiner, Tim R. Tumlin, Tanya Tompkins

Faculty Publications

Increasing emphasis on interprofessionalism and teamwork in healthcare renders psychologists’ collaborations critical and invites reexamination of psychologists’ roles related to medications. The Collaboration Level outlined by the APA’s Ad Hoc Task Force is more achievable and in synch with health reform than prescription privileges (RxP). RxP remains controversial due to training and safety concerns, lacking support from health professionals, psychologists, and consumers. Differences in educational preparation of psychologists relative to prescribing professionals are discussed. Enactment of only three of 170 RxP initiatives reveals RxP to be a costly, ineffectual agenda. Alternatives (e.g., integrated care, collaboration, telehealth) increase access without risks …


The Effect Of Visual Wulst Lesions And Trigeminal Nerve Sectioning On The Discrimination Of Magnetic Inclination In The Homing Pigeon (Columba Livia), Merissa Acerbi Jan 2013

The Effect Of Visual Wulst Lesions And Trigeminal Nerve Sectioning On The Discrimination Of Magnetic Inclination In The Homing Pigeon (Columba Livia), Merissa Acerbi

Honors Projects

The ability of homing pigeons to return to their loft from unknown places has fascinated scientists for centuries. It is well established that homing pigeons, like migratory birds, posses an innate magnetic inclination compass to determine direction by measuring the angle between the magnetic field vector and the Earth's surface. Recent work has indicated that the avian magnetic compass is light mediated and appears to mediate magnetic information to the brain. This occurs via a visual pathway with processing in the visual Wulst area of the forebrain. There is, however, also evidence from other avian species that magnetic direction may …


Protective Effects Of The Alcohol Dehydrogenase-Adh1b Allele, Neil Dodge Jan 2013

Protective Effects Of The Alcohol Dehydrogenase-Adh1b Allele, Neil Dodge

Wayne State University Theses

Alcohol dehydrogenase is a critical enzyme in the metabolism of alcohol. Expression of three alleles at the ADH1B locus results in enzymes that differ in turnover rate and affinity for alcohol. The ADH1B*3 allele, which appears to be unique to African Americans, is associated with more rapid alcohol metabolism than the more prevalent ADH1B*1 allele. It has been previously demonstrated that the presence of at least one maternal ADH1B*3 allele confers a protective effect against alcohol teratogenicity in African American infants and children. This study was conducted to determine whether the presence of the ADH1B*3 allele in the mother or …


Olanzapine Sensitization And Clozapine Tolerance: From Adolescence To Adulthood In The Conditioned Avoidance Response Model, Jing Qiao, Hong Li, Ming Li Jan 2013

Olanzapine Sensitization And Clozapine Tolerance: From Adolescence To Adulthood In The Conditioned Avoidance Response Model, Jing Qiao, Hong Li, Ming Li

Department of Psychology: Faculty Publications

Disruption of conditioned avoidance response (CAR) in rodents is one trademark feature of many antipsychotic drugs. In adult rats, repeated olanzapine (OLZ) treatment causes an enhanced disruption of avoidance response (sensitization), whereas repeated clozapine (CLZ) treatment causes a decreased disruption (tolerance). The present study addressed (1) whether OLZ sensitization and CLZ tolerance can be induced in adolescent rats, and (2) the extent to which OLZ sensitization and CLZ tolerance induced in adolescence persists into adulthood. Male adolescent Sprague–Dawley rats (approximate postnatal days (BP) 43–47) were first treated with OLZ (1.0 or 2.0 mg/kg, subcutaneously (sc)) or CLZ (10 or 20 …


Guilty By Association: Time-Dependent Memory Consolidation And The Generalization Of Person-Specific Traits To Other Group Members, Luke R. Enge Jan 2013

Guilty By Association: Time-Dependent Memory Consolidation And The Generalization Of Person-Specific Traits To Other Group Members, Luke R. Enge

Open Access Theses & Dissertations

The following study investigated the extent to which time-dependent memory consolidation facilities the generalization of person-specific traits (individuated targets) to other, familiar social group members (familiar targets) Sixty-Nine (N = 69) participants learned to distinguish between two arbitrary groups, one positive and one negative. Participants learned the negative or positive information about a subset of the group members (individuated targets) and no individuating information about the familiar targets. Participants returned either without a time-delay containing sleep (2-6 hours after learning) or a time-delay with sleep (48 hours after learning). Results demonstrated that only after a time-delay containing sleep, negative information …


An Intra-Individual Event-Related Potential-Based Concealed Attitude Test, David R. Herring Jan 2013

An Intra-Individual Event-Related Potential-Based Concealed Attitude Test, David R. Herring

Open Access Theses & Dissertations

The evaluative oddball is an implicit measure for detecting (concealed) attitudes. In evaluative oddball studies, low occurrence stimuli such as negative pictures are presented among high occurrence context stimuli such as positive pictures. Late positive potentials (LPPs) of the event-related potential (ERP) are larger to evaluatively incongruent stimuli such as negatives compared to congruent stimuli such as positives with the context (e.g., positives). In prior evaluative oddball paradigms, this evaluative congruity effect of the LPP was reduced when participants concealed compared to truthfully reported attitudes. Because prior evaluative oddballs have been focused on the group level analysis, it has been …


Assessing Naturalistic Decision Making By Experienced And Inexperienced Interrogators In High Stakes Interviews, Amy Bethany Ross Jan 2013

Assessing Naturalistic Decision Making By Experienced And Inexperienced Interrogators In High Stakes Interviews, Amy Bethany Ross

Open Access Theses & Dissertations

The current thesis aimed to improve the ecological validity of human intelligence interrogation research. Although field practitioners and researchers have worked together to improve the scientific validity and practical execution of interrogation techniques, research has yet to understand how, when and why interrogators implement such techniques. This thesis investigated the active decision making processes of interrogators that occur during high value interrogations. The theory of Naturalistic Decision Making was used to capture the naturalistic characteristics of high value interrogations- ambiguity, time pressure and high stakes. To capture the decision-making processes that are associated with skilled performance, this research conducted in-depth …


The Lives Of Others: Social Rationality In Animals, Jeffrey R. Stevens, Andrew J. King Jan 2013

The Lives Of Others: Social Rationality In Animals, Jeffrey R. Stevens, Andrew J. King

Jeffrey Stevens Publications

Darwin (1871) boldly claimed that humans and other animals differ very little in their cognition; a statement that has raised the ire of many scientists (Bolhuis & Wynne, 2009; Penn, Holyoak, & Povinelli, 2008). Rather than stating this continuity as a fact, we will explore the similarities and differences between humans and animals in the social rationality of their decision making. We find this a fruitful exercise because it can profit researchers of both humans and animals. Our purpose here is to provide an evolutionary background of social rationality: Why do animals attend to the lives of others? To this …


Changing Room Cues Reduces The Effects Of Proactive Interference In Clark’S Nutcrackers, Nucifraga Columbiana, Jody L. Lewis, Alan C. Kamil, Kate E. Webbink Jan 2013

Changing Room Cues Reduces The Effects Of Proactive Interference In Clark’S Nutcrackers, Nucifraga Columbiana, Jody L. Lewis, Alan C. Kamil, Kate E. Webbink

Avian Cognition Papers

To determine what factors are important for minimizing interference effects in spatial memory, Clark’s Nutcrackers, Nucifraga columbiana were tested for their spatial memory for two serial lists of locations per day. In this experiment two unique landmark sets were either different between List 1 and List 2 or the same. We found that Nutcrackers were most susceptible to interference when the landmark sets were the same. This study suggests that repeatedly testing animal memory in the same room, with the same cues, can hamper recall due to interference.


Differences In Relative Hippocampus Volume And Number Of Hippocampus Neurons Among Five Corvid Species, Kristy L. Gould, Karl E. Gilbertson, Andrew J. Hrvol, Joseph C. Nelson, Abigail L. Seyfer, Rose M. Brantner, Alan C. Kamil Jan 2013

Differences In Relative Hippocampus Volume And Number Of Hippocampus Neurons Among Five Corvid Species, Kristy L. Gould, Karl E. Gilbertson, Andrew J. Hrvol, Joseph C. Nelson, Abigail L. Seyfer, Rose M. Brantner, Alan C. Kamil

Avian Cognition Papers

The relative size of the avian hippocampus (Hp) has been shown to be related to spatial memory and food storing in two avian families, the parids and corvids. Basil et al. [Brain Behav Evol 1996;47: 156-164] examined North American food-storing birds in the corvid family and found that Clark’s nutcrackers had a larger relative Hp than pinyon jays and Western scrub jays. These results correlated with the nutcracker’s better performance on most spatial memory tasks and their strong reliance on stored food in the wild. However, Pravosudov and de Kort [Brain Behav Evol 67 (2006), 1-9] raised questions …


Impulsiveness Mediates The Association Between Gabra2 Snps And Lifetime Alcohol Problems, S. Villafuerte, V. Strumba, S. F. Stoltenberg, R. A. Zucker, M. Burmeister Jan 2013

Impulsiveness Mediates The Association Between Gabra2 Snps And Lifetime Alcohol Problems, S. Villafuerte, V. Strumba, S. F. Stoltenberg, R. A. Zucker, M. Burmeister

Department of Psychology: Faculty Publications

Genetic variants in GABRA2 have previously been shown to be associated with alcohol measures, electroencephalography (EEG) β waves and impulsiveness-related traits. Impulsiveness is a behavioral risk factor for alcohol and other substance abuse. Here, we tested association between 11 variants in GABRA2 with NEO-impulsiveness and problem drinking. Our sample of 295 unrelated adult subjects was from a community of families with at least one male with DSM-IV alcohol use diagnosis, and from a socioeconomically comparable control group. Ten GABRA2 SNPs (single-nucleotide polymorphisms) were associated with the NEO-impulsiveness (P < 0.03). The alleles associated with higher impulsiveness correspond to the minor alleles identified in previous alcohol dependence studies. All ten SNPs are in linkage disequilibrium (LD) with each other and represent one effect on impulsiveness. Four SNPs and the corresponding haplotype from intron 3 to intron 4 were also associated with Lifetime Alcohol Problems Score (LAPS, P < 0.03) (not corrected for multiple testing). Impulsiveness partially mediates (22.6% average) this relation between GABRA2 and LAPS. Our results suggest that GABRA2 variation in …


Rats Acquire Stronger Preference For Flavors Consumed Towards The End Of A High-Fat Meal, Kevin P. Myers Jan 2013

Rats Acquire Stronger Preference For Flavors Consumed Towards The End Of A High-Fat Meal, Kevin P. Myers

Faculty Journal Articles

Rats learn to prefer flavors associated with postingestive effects of nutrients. The physiological signals underlying this postingestive reward are unknown. We have previously shown that rats readily learn to prefer a flavor that was consumed early in a multi-flavored meal when glucose is infused intragastrically (IG), suggesting rapid postingestive reward onset. The present experiments investigate the timing of postingestive fat reward, by providing distinctive flavors in the first and second halves of meals accompanied by IG fat infusion. Learning stronger preference for the earlier or later flavor would indicate when the rewarding postingestive effects are sensed. Rats consumed sweetened, calorically-dilute …


Ketamine Induced Deficits In Working Memory With Relevance To Schizophrenia, Michael A. Langhardt, Jefferson Kinney Jan 2013

Ketamine Induced Deficits In Working Memory With Relevance To Schizophrenia, Michael A. Langhardt, Jefferson Kinney

McNair Poster Presentations

Schizophrenia is a chronic debilitating brain disorder, which affects approximately one per­cent of the adult population worldwide. The symptoms of schizophrenia are commonly divided into three broad classes: positive symptoms, negative symptoms, and cognitive disturbances (Kay, et al., 1987). The positive symptoms of schizophrenia include hallucinations, delusions, and dis­organized thinking, while the negative symptoms include affective flattening, social withdrawal, and an inability to plan and carry out future activities. The cognitive disturbances exhibited in schizophrenia include deficits in spatial reference and working memory as well as difficulties with focus and attention (Lewis et. al., 2007). Several models have been proposed …


An Acute Inflammatory Response In A Diabetic Alzheimer’S Disease Model, Krystal Courtney D. Belmonte, Jefferson Kinney Jan 2013

An Acute Inflammatory Response In A Diabetic Alzheimer’S Disease Model, Krystal Courtney D. Belmonte, Jefferson Kinney

McNair Poster Presentations

Alzheimer’s disease (AD) is the most common form of dementia, accounting for 50 to 80 percent of all dementia cases. This neurodegenerative disease leads to neuronal death and tissue loss in the brain, resulting in the slow deterioration of memory, thinking skills, and eventually even the ability perform daily tasks. While it is not a normal part of aging, AD is mostly diagnosed in people over the age of 65; thus, the main risk factor for Alzheimer’s disease is increased age, though it is most likely other additional factors also contribute (Heese & Akatsu, 2006). Neuropathological hallmarks of AD include …


Expression Of Borderline Personality Disorder Symptoms Across The Ovulatory Cycle: A Multilevel Investigation, Tory A. Eisenlohr-Moul Jan 2013

Expression Of Borderline Personality Disorder Symptoms Across The Ovulatory Cycle: A Multilevel Investigation, Tory A. Eisenlohr-Moul

Theses and Dissertations--Psychology

Borderline Personality Disorder (BPD) is a disabling condition characterized by chronic emotion dysregulation and behavioral impulsivity. Prospective studies that test proposed mechanisms of within-person change in BPD hold the key to improving symptom predictability and control in this disorder. A small body of evidence suggests that fluctuations in estradiol such as those occurring naturally at ovulation during the monthly female reproductive cycle may increase symptoms in women with BPD (DeSoto et al., 2003). Furthermore, there is preliminary evidence that both self-esteem and feelings of social rejection are highest at ovulation, when estradiol peaks (Durante and Hill, 2009; Eisenlohr-Moul et al., …


Developmental Changes In Postural Stability During The Performance Of A Precision Manual Task, Jeffrey M. Haddad, Laura J. Claxton, Dawn Melzer, Joseph Hamill, Richard E. A. Van Emmerik Jan 2013

Developmental Changes In Postural Stability During The Performance Of A Precision Manual Task, Jeffrey M. Haddad, Laura J. Claxton, Dawn Melzer, Joseph Hamill, Richard E. A. Van Emmerik

Psychology Faculty Publications

Posture becomes integrated with other goal-directed behaviors early in infancy and continues to develop into the second decade of life. However, the developmental time course over which posture is stabilized relative to the base of support during a dynamic manual precision task has not been examined. Postural-manual integration was assessed in 7-year-olds, 10-year-olds, and adults using a postural-manual task in which task precision (target fitting size) and postural difficulty (reaching distance to a target) were manipulated. The main dependent variable was postural time-to-contact (TtC). Results indicated systematic age effects in which TtC was shortest in the 7-year-olds, increased in the …


Prenatal Stress, Depression, And Herpes Viral Titers, Pao-Chu Hsu Jan 2013

Prenatal Stress, Depression, And Herpes Viral Titers, Pao-Chu Hsu

USF Tampa Graduate Theses and Dissertations

Recent studies suggest that some cases of prenatal depression may be associated with reactivation of latent infections of the herpesvirus family. The possible relationships among stress, prenatal depression, and herpes viral reactivation in pregnancy are understudied and the molecular pathways such as the neuroimmune biogenic amine pathway are unidentified. Chronic stress shifts the T helper-1 cell (Th1) cytokine profile to a Th2 profile, which favors virus induced pathogenesis and survival. Pregnancy is also associated with a similar Th2 dominance. In non-pregnant individuals, exposure to psychological or physical stress may be associated with latent herpes viral reactivation and could result in …


A Preliminary Investigation Of The Validity Of Time-Based Measures Of Sustained Attention For Children, Michael R. Kulfan Jan 2013

A Preliminary Investigation Of The Validity Of Time-Based Measures Of Sustained Attention For Children, Michael R. Kulfan

Antioch University Dissertations & Theses

This study is a preliminary investigation of the validity of using time-based measures to quantify sustained attention in children ages 6-12. Problems with sustained attention negatively affect childhood learning and development. The prevalence of disorders known to impact sustained attention performance continue to rise in the United States. Currently, commercially available, objective measures of sustained attention use normative comparisons that provide limited information about the effect such problems have on child performance in natural settings. We reviewed test data from 290 charts of children ages 6-12 referred for neuropsychological evaluation. The Test of Everyday Attention for Children (TEA-Ch) is an …


Chronic Stress Elevates Telomerase Activity In Rats, Annaliese K. Beery, Jue Lin, Joshua S. Biddle, Darlene D. Francis, Elizabeth H. Blackburn, Elissa S. Epel Dec 2012

Chronic Stress Elevates Telomerase Activity In Rats, Annaliese K. Beery, Jue Lin, Joshua S. Biddle, Darlene D. Francis, Elizabeth H. Blackburn, Elissa S. Epel

Neuroscience: Faculty Publications

The enzyme telomerase lengthens telomeres—protective structures containing repetitive DNA sequences at chromosome ends. Telomere shortening is associated with diseases of ageing in mammals. Chronic stress has been related to shorter immune-cell telomeres, but telomerase activity under stress may be low, permitting telomere loss, or high, partially attenuating it. We developed an experimental model to examine the impacts of extended unpredictable stress on telomerase activity in male rats. Telomerase activity was 54 per cent higher in stressed rats than in controls, and associated with stress-related physiological and behavioural outcomes. This significant increase suggests a potential mechanism for resilience to stress-related replicative …


Effects Of Neonatal Hypoxic Ischemic Brain Injury On Spatial Working Memory, Amanda L. Smith Dec 2012

Effects Of Neonatal Hypoxic Ischemic Brain Injury On Spatial Working Memory, Amanda L. Smith

Master's Theses

Children born prematurely or at very low birth weight (VLBW) have an increased risk for hypoxic ischemic brain injury (HI). HI refers to a lack of adequate blood and oxygen flow in the brain. HI can also occur in the term infant due to birth complications such as prolonged labor, placental dysfunction, or cord prolapse. In both populations (though exact patterns of neuropathology vary) brain damage is likely to occur in the form of decreased hippocampal and cortical volume, and enlargement of the ventricles (Kesler et al., 2004, Nagy et al., 2009). Resulting neuropathology can in turn lead to cognitive …