Forensic Science and Technology Commons^™

Identifying Cystic Fibrosis (Cf) Skeletally: A Proposed Differential Diagnosis, Clare Remy

EURēCA: Exhibition of Undergraduate Research and Creative Achievement

Cystic fibrosis (CF) is an inherited disorder that affects the mucosal lining of the lungs and digestive system due to a defective gene that causes blockages of tubes, ducts, and passageways. The type of mutation correlates with the severity of the condition, but with modern medicine individuals can live into their 50s. We propose a differential diagnosis for identifying CF in the skeleton based on bony pathologies that occur in higher frequency in CF patients. CF patients exhibit chronic sinusitis, clubbing of hands and feet, vertebral fractures/collapse and abnormal curvature, significantly shorter stature, lower bone density, rib fractures, and an …