Health Communication Commons^™

Sex And Gender In Ageing And Longevity: Highlights From An International Course, Giuseppina Candore, Giulia Accardi, Anna Aiello, Giovannella Baggio, Tiziana Bellini, Vittorio Calabrese, Anna Paola Carreca, Ignazio Carreca, Anna Masucci, Monica Cattaneo, Serena Dato, Danilo Di Bona, Luca Fabris, Caterina Gambino, Gabriele Di Lorenzo, Claudio Franceschi, Mattia Emanuela Ligotti, Maria Cristina Manfrinato, Annibale Alessandro Puca, Martina Tamburello, Roberta Vassallo, Calogero Caruso

Translational Medicine @ UniSa

Gender medicine is a multidisciplinary science and represents an important perspective for pathophysiological and clinical studies in the third millennium. Here, it is provided an overview of the topics discussed in a recent course on the Role of Sex and Gender in Ageing and Longevity. The paper highlights three themes discussed in the course, i.e., the interaction of gender/sex with, i) the pathophysiology of age-related diseases; ii), the role of genetics and epigenetics in ageing and longevity and, iii) the immune responses of older people to pathogens, vaccines, autoantigens, and allergens. Although largely unexplored, sex and gender are modulators …

Dpo: Diffuse Pulmonary Ossification - A Diagnostic Challenge, Gaetano Rea, Giuliana Giacobbe, Danila Caroppo, Silvia Iovine, Roberta Lieto, Marialuisa Bocchino, Tullio Valente, Angelantonio Maglio, Alessandro Vatrella

Translational Medicine @ UniSa

Diffuse pulmonary ossification (DPO) is a rare condition of DLD (diffuse lung disease) characterized by the presence of metaplastic ectopic bone in the lungs and is less frequent in patients without a clear background of lung diseases. DPO is characterized by very small calcific nodules, often with bone mature located in both lungs and often in peripheral areas of the lungs. Two patterns of DPO have been recognized dendriform and nodular. The dendriform type is less common and is characterized by a coral-like network of bone spiculae along the alveolar septa and is often related to interstitial fibrosis or chronic …

Globularia Alypum L. Modulates Inflammatory Markers In The Human Colon And Shows A Potential Antioxidant Role In Myeloid Leukemic Cells, Najla Hajji, Elodie Hudik, Paola Iovino, Nacim Zouari, Hichem Sebai, Oliver Nusse, Carolina Ciacci

Translational Medicine @ UniSa

Globularia alypum (GA), a plant of the Globulariacea family, has long been used as a traditional cure for inflammatory and metabolic illnesses.In addition to various in vitro model studies, the current work focuses on GA'santioxidant and anti-inflammatory properties in human colon biopsies.

Liquid Chromatography-Electrospray Ionization Mass Spectrometry identified the phenol components in GA aqueous extract (GAAE).The antioxidant ability of GAAE was tested in vitro utilizing chemiluminescence and flow cytometry using fluorescent yeastsn conjunction with PLB-985-human myeloid leukemia cells. Experiments on human colon biopsies after a biopsy challenge with Escherichia coli-lipopolysaccharides aimed tosee if GAAE had an anti-inflammatory impact on human …

The Time For A Consensus Regarding The Coeliac Disease Diagnosis In Adults Has Come: Balancing The Pros And Cons Of Omitting The Biopsy, Carolina Ciacci, Julio C. Bao

Translational Medicine @ UniSa

How balancing the pros and cons of omitting the biopsy in diagnosing CeD in adults?

Possible Association Of Telomere Length With Sleep Duration. A Preliminary Pilot Study In A Sicilian Cohort With Centenarians., Anna Aiello, Giulia Accardi, Sawan Alì, Calogero Caruso, Maxine Chen, Immaculata De Vivo, Mattia Emanuela Ligotti, Giovanni Scapagnini, Sergio Davinelli, Giuseppina Candore

Translational Medicine @ UniSa

Telomere length (TL) is considered a biomarker of ageing although this topic is still debated. Also, sleep pattern changes are physiological part of the normal ageing process. In fact, it is widely recognized that sleep duration declines with age, leading to dysregulation of circadian rhythms. The aim of our study was to analyse the possible association of sleep duration with TL in a sample of 135 subjects with ages ranging from 20 to 111 years, recruited from Palermo and neighbouring municipalities in Sicily (Italy). Preliminary data suggest that relative TL (RTL) decreases with age in both men and women. However, …

Role Of Bpifb4 In Immune System And Cardiovascular Disease: The Lesson From Centenarians, Francesco Montella, Valentina Lopardo, Monica Cattaneo, Albino Carrizzo, Carmine Vecchione, Elena Ciaglia, Annibale A. Puca

Translational Medicine @ UniSa

Recent discoveries have shed light on the participation of the immune system in the physio pathology of the cardiovascular system underpinning the importance of keeping the balance of the first to preserve the latter. Aging, along with other risk factors, can challenge such balance triggering the onset of cardiovascular diseases.

Among several mediators ensuring the proper cross-talk between the two systems, bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) has been shown to have a pivotal role, also by sustaining important signals such as eNOS and PKC-alpha.

In addition, the Longevity-associated variant (LAV), which is an haplotype allele in BPIFB4characterized by …

The Iterative Model Of Ethical Analysis For Large-Scale Implementation Of Ict Solutions, Carina Dantas

Translational Medicine @ UniSa

This manuscript presents a model and the methodology to understand and define the ethical management of the large-scale implementation of ICT solutions for Active and Healthy Ageing. Based on project expertise, including experience from the Pharaon project Horizon2020, this model includes an understanding of the main ethical challenges and the development of the necessary guidelines, measures, and tools for different stakeholder profiles. This model extends beyond conventional ethical guidelines, providing a methodology to actively discuss ethical and societal challenges within a project based on interactive and iterative dialogue between the entire value-chain of stakeholders. One of the cornerstones in the …

The Ant Home Care Model In Palliative And End-Of-Life Care. An Investigation On Family Caregivers’ Satisfaction With The Services Provided., Veronica Zavagli

Translational Medicine @ UniSa

The World Health Organization plan for a Decade of Healthy Ageing 2020-2030 has established some priorities in the field of palliative and end-of-life care. It states that “people require non-discriminatory access to good-quality palliative and end-of-life care” and recommends the “implementation of strategies for the provision of information, training, respite and support for informal caregivers”. The priorities described are in line with the home care services that National Tumor Assistance (ANT) Foundation has been providing in Italy. This 5-years investigation was designed to measure caregivers’ satisfaction and determine what types of support services are associated with greater satisfaction. 5.441 family …

Learning To Implement Smart Healthy Age-Friendly Environments, Willecke Van Staalduinen

Translational Medicine @ UniSa

To develop trainings on the implementation of smart healthy age-friendly environments for people who aim to support, for example, their parents, their neighbours or local community, there are precautionary measures that have to be taken into account: the role of the facilitator (volunteer or self-employed), the level of skills, the needs of the end-users, training content and methodologies together with the sustainability of the learning. This article examines these aspects, based on desk research and expert interviews in the Smart Healthy Age-Friendly Environments (SHAFE) fields

From The Bench To Practice – Field Integration Of Community-Based Services For Older Citizens With Different Levels Of Functional Limitation Across European Regions, Regina Roller-Wirnsberger

Translational Medicine @ UniSa

The meeting of the European Innovation Partnership on Active and Healthy Ageing (EIPonAHA) action group A3 together with members of the Reference site collaborative network (RSCN) in December 2019 in Rome focused on integration of evidence-based approaches on health and care delivery for older citizens at different levels of needs with expertise coming from stakeholder across Europe. It was the final aim of the group to co-create culturally sensitive pathways and facilitate co-ownership for further implementation of the pathways in different care systems across Europe.

The study design is a mixed method approach. Based on data analysis from a cohort …

Go For It! Exercising Makes You Happy And Strong., Donatella Tramontano

Translational Medicine @ UniSa

Despite it is generally recognized the beneficial role of physical activity, large portion of the population is physically inactive. Very alarmingly, the well-known gender gap in physical activity is constantly increasing. Several barriers obstacle women to perform physical activity although exercising would be of paramount importance for their health in particular during pregnancy and menopause. In addition to physical health benefits, physical activity may influence well-being and resilience, greatly impacting on quality of life.

Here we explore the relationship between physical activity resilience and well-being in a group of 1107 female residents in the Metropolitan area of Naples.

Pilot Study On The Effectiveness Of Reminiscence Therapy On Cognition, Depressive Symptoms, And Quality Of Life In Nursing Home Residents, Isabel Gil

Translational Medicine @ UniSa

This study aimed to assess the effectiveness of the group Reminiscence Therapy (RT) on cognition, depressive symptoms, and quality of life (QOL) in older adults recruited in nursing homes. Methods: A pilot study with a one-group pretest-posttest design was conducted between September 2017 and March 2018 in five nursing homes from central Portugal. A comprehensive RT program (Core program followed by a Follow-up program) was provided to clinically stable volunteers aged 65 years or more, who did not have severe cognitive impairment. Results: From the 50 older adults (32 women and 18 men, with mean age of 83.32±7.76, and mean …

The Management Of Asymptomatic Carotid Stenosis: Is There A Benefit To Operate Elderly Patients?, Mohamed Nadjib Bouayed

Translational Medicine @ UniSa

We present a retrospective study of a series of 40 patients over the age of 75 operated for an asymptomatic carotid stenosis. The results were evaluated during an average of 3 years of follow-up. Material and method. The study is retrospective and monocentric. The series includes 40 patients aged over 75 years and with an average age of 78.5 years (range 75-82). Patients underwent surgery for an asymptomatic carotid stenosis of more than 80%. The technique in all case was a carotid endarterectomy. Results. There have been no postoperative deaths or neurological adverse events. During an average follow-up of 3 …

Good Practices For A “Decade For Active And Healthy Ageing”, Maddalena Illario

Translational Medicine @ UniSa

Ageing is a success story of Public Health worldwide, but poses many challenges that hinder its transformation into an opportunity for sustainable development: infectious outbreaks and public health emergencies, chronic diseases, social inequalities, environmental issues and more.

Head And Neck Surgery Residency During Covid-19 Pandemic. Lessons From Southern Italy, Pietro De Luca

Translational Medicine @ UniSa

A letter to the Editor from an otolaryngology-head and neck surgery resident.

Decluttering, Carolina Ciacci, Ornella Piazza

Translational Medicine @ UniSa

our point of view on the COVID-19 pandemic in a confessional style.

Saving Limited Resources During Covid-19 Pandemic, Ornella Piazza

Translational Medicine @ UniSa

An epidemic is not only a disease but a social crisis.

Assessing The Impact Of A Community-Based Pro-Active Monitoring Program Addressing The Need For Care Of Community-Dwelling Citizens Aged More Than 80: Protocol For A Prospective Pragmatic Trial And Results Of The Baseline Assessment, Elisa Terracciano

Translational Medicine @ UniSa

The aim of this paper is to describe the protocol of a study assessing the impact of a Communitybased pro-Active Monitoring Program, by measuring the effect in counteracting the adverse outcomes related to frailty. Methods: a prospective pragmatic trial will be carried out to describe the impact of an intervention on people aged>80, adjusted for relevant parameters: demographic variables, comorbidities, disability and bio-psycho-social frailty. They have been assessed with the Functional Geriatric Evaluation questionnaire that is a validated tool. Mortality, Acute Hospital Admission rates, Emergency Room Visit rates and Institutionalization rates are the main outcomes to be evaluated annually, …

The Frailty Of The Invincible, Donatella Tramontano

Translational Medicine @ UniSa

The COVID-19 pandemic has unveiled the frailty of our societies from too many points of view to look away. We need to understand why we were all caught unprepared. On the one hand, we have all short memories. As we forget too quickly, we were unable to recognize key factors influencing response and preparedness to public health threats. For many years, economic evaluation pushed governments all over the world to cut resources for public health systems, with COVID-19 pandemic the question arises: do we spend too much or too little on health care? What is the right amount to spend …