Social and Behavioral Sciences Commons^™

The Effect Of Henna And Bleach Treatments On Cocaine Hair External Contamination, Alexandra Dombroski

Student Theses

Hair external contamination is a challenging phenomenon that may compromise hair testing interpretation. Previous research has found that cosmetic hair treatments can decrease concentrations of drugs that are already present in the hair shaft, however little is known about the impact of these treatments on the hair when the drugs are deposited externally. The aims of the present study were to explore how henna and bleach treatments influence cocaine external contamination. Sixteen authentic hair samples were collected from volunteers with varying hair colors and shapes and were confirmed negative for cocaine and benzoylecgonine by a fully validated LC-MS/MS method. Each …

Effects Of External Decontamination Of Methamphetamine In Juvenile Hair, Rebecca Mitrani

Student Theses

Methamphetamine is a common illicit substance abused in the United States. Hair is one matrix that is analyzed to determine the presence and concentration of methamphetamine. When hair is analyzed, an external decontamination step is commonly performed prior to drug extraction to avoid a potential positive result from environmental exposure in someone that has not ingested the drug themselves. In child-custody scenarios, however, it is important to know if a child is often around such illicit substances. This study serves to assess if there is a significant difference in methamphetamine concentrations in samples from children up to 12 years old …

Elisa Validation Method For The Detection Of Ketamine In Hair, Daria A. Centonza

Student Theses

An ELISA method was developed and validated to detect ketamine in human hair samples. Ketamine is an anesthetic drug that causes memory loss, dissociative sensations, and hallucinations. Due to these adverse effects, ketamine is a common drug used in drug facilitated sexual assaults (DFSAs). It is very important to be able to detect the substances used in DFSAs over a longer period of time due to the delayed reporting of these crimes. Victims, often out of fear and from the sedative/memory loss effects of the drugs, tend to report these crimes when it is too late to use urine and …

Drug-Facilitated Sexual Assault At The University Of Arkansas, Barrett Weidman

Chemical Engineering Undergraduate Honors Theses

This work was written to fulfill two main purposes. First, to help survivors of Drug-Facilitated Sexual Assault (DFSA) process their experience by compiling the toxicological, pharmacological, and distribution of the three most used date-rape drugs. Second, to gauge the knowledge and interest of University of Arkansas students regarding drug impairments, sexual assault education, and bystander intervention training. A survey was conducted for the latter and revealed that 91.6% of students believe the University’s existing sexual assault prevention education and bystander intervention training have room for improvement. Also, 37.1% of students who have received this education report that the programming does …

Assessment Of Quechers Extraction Protocol For The Lc-Ms/Ms Detection Of Emerging Fentanyl Analogs In Biological Specimens For Clinical And Forensic Purposes, Kylea M. Morris

Graduate Theses, Dissertations, and Problem Reports

Drug abuse within the United States is a dynamic and pervasive issue that affects the quality and life expectancy of our society. One of the major drug classes that are constantly utilized is opioids. Opioids are prescribed for pain management in patients suffering from cancer and other medical illnesses. Long-term use of opioids could lead to tolerance in humans, which poses a risk of reaching fatal overdose levels. Unfortunately, opioids are abused recreationally, and in some instances, individuals are unaware of the presence of dangerous synthetic drugs like fentanyl, hidden in materials such as heroin, cocaine, oxycodone, and methamphetamine. Recent …

Investigation Of Postmortem Methamphetamine Cases Submitted To The New York City Office Of Chief Medical Examiner, Isaiah Jewell

Student Theses

Methamphetamine (N-methylamphetamine) is a central nervous system stimulant (CNS) and sympathomimetic drug with a high addiction potential. In the United States, there has been a significant increase in the presence of methamphetamine in recent years, specifically in the Northeastern region of the country. The New York City Office of Chief Medical Examiner (NYC-OCME) postmortem methamphetamine casework from 2018 and 2019 was analyzed and revealed that the presence of the drug increased drastically within a span of one year, jumping from 65 cases in 2018 to 99 cases in 2019. Males were overwhelmingly responsible for much of the casework, taking up …

New Demands In Basic Research On Environmental Pollution And Health In China, Qian Liu, Guangbo Qu, Dawei Lu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The complex environmental pollution in China greatly threatens the human health. Although the pollution control policies have taken a great effect in recent years, the resultant long-term, chronic health risks are still concerned. Until now, the causes of many regional high-incidence diseases are still unclear. In order to solve these environmental health problems, we need multi-disciplinary innovations in basic research to establish the comprehensive research chain of "pollution process-human exposure-body response-disease development". We need breakthroughs in interdisciplinary fields including exposomics, ultratrace measurement and source tracing methodology, molecular epidemiology, environmental big data, and artificial intelligence. Only in this way can we …

Assessing The Toxicity Of A Reconstituted Water Simulating Streams Influenced By Mountaintop Mining In Central Appalachia, Benjamin David Browning

Theses, Dissertations and Capstones

Freshwater ecosystems in Central Appalachia experience increased concentrations of manganese (Mn) and total dissolved solids from the runoff of surface mines and valley fills. Biological communities have been impacted by these surface mining operations and it has been suggested that the increase in total dissolved solids may contribute to these negative effects, but standard laboratory toxicity tests have not found increased concentrations of total dissolved solids to have such negative effects as seen in the field. The elevated total dissolved solids in mining influenced streams may only be toxic in conjunction with another toxicant that is presence in these systems …

Dop-Coroners’ Study 2019 Final Report: Assessing Coroners’ Needs, Brittany Willmore, B. Shine Cho, Jeanette Harder

Reports

The Nebraska Department of Health and Human Services (DHHS) partnered with Support and Training for the Evaluation of Programs (STEPs) at the University of Nebraska at Omaha to assess the needs of Nebraska county coroners in conducting drug overdose death investigations.

To develop a clear understanding of the Nebraska county coroners’ needs, STEPs conducted an online survey of 91 county coroners who are serving 93 Nebraska counties, according to Nebraska DHHS’s internal data. STEPs administered the survey on July 23, 2019, and closed it on August 16, 2019. 28 people participated in the survey and 25 completed it, giving a …

Zolpidem Facilitated Sexual Assaults: A Hair Method Validation, Danielle N. Chasworth

Student Theses

A liquid chromatography tandem mass spectrometry (LC-MSMS) method was developed and validated to detect for the presence of zolpidem in human hair samples. Zolpidem is a sedative hypnotic whose adverse effects make it a common drug found in drug facilitated crimes (DFC). It is important to be able to detect and quantitate the drug after a long period of time due to the victim’s delayed reporting of the crime. Hair’s long window of detection makes it a useful matrix for DFC investigations. The linear range of the assay was targeted at 2 pg/mg to 1,000 pg/mg and experiments designed to …

Forensic Markers Of Lampricide Toxicity In Oncorhynchsus Mykiss, Chris White

Theses and Dissertations (Comprehensive)

The lampricide 3-trifluoromethyl-4-nitrophenol (TFM) has been used for decades to control invasive sea lamprey (Petromyzon marinus) populations in the Great Lakes, normally with little harm to other fish populations. However, due to the nature of lampricide treatments and the chemical properties of TFM, adverse effects to non-target fishes and non-target mortality occasionally occur. However, investigations of non-target mortality can be complex, particularly if fish deaths are not noticed immediately, due to decomposition of the carcasses. The objectives of this thesis were to expose rainbow trout (Oncorhynchsus mykiss) to TFM in order to: (i) identify forensic markers …

Poison In Pink, Sydney V. Cook

Graduate Student Theses, Dissertations, & Professional Papers

Humans slather, spray, mist, and cleanse their bodies with personal care products like lotion, hairspray, cologne, and shampoo every day. Our cupboards are stocked full of them, but few of us understand what is in those jars and bottles. We trust that if it’s on the shelf at the store, it’s safe. However, this is not always the case, and many personal care products contain chemicals that are harmful to human and environmental health.

My multi-disciplinary Environmental Studies thesis project combines evidenced-based research, interviews, nonfiction narrative, and science communication to create part of a book manuscript intended to educate general …

An Analysis Of The Use Of Dogs In Predicting Human Toxicology And Drug Safety, Jarrod Bailey, Michelle Thew, Michael Balls

Jarrod Bailey, PhD

Dogs remain the main non-rodent species in preclinical drug development. Despite the current dearth of new drug approvals and meagre pipelines, this continues, with little supportive evidence of its value or necessity. To estimate the evidential weight provided by canine data to the probability that a new drug may be toxic to humans, we have calculated Likelihood Ratios (LRs) for an extensive dataset of 2,366 drugs with both animal and human data, including tissue-level effects and Medical Dictionary for Regulatory Activities (MedDRA) Level 1–4 biomedical observations. The resulting LRs show that the absence of toxicity in dogs provides virtually no …

Predicting Human Drug Toxicity And Safety Via Animal Tests: Can Any One Species Predict Drug Toxicity In Any Other, And Do Monkeys Help?, Jarrod Bailey, Michelle Thew, Michael Balls

Jarrod Bailey, PhD

Animals are still widely used in drug development and safety tests, despite evidence for their lack of predictive value. In this regard, we recently showed, by producing Likelihood Ratios (LRs) for an extensive data set of over 3,000 drugs with both animal and human data, that the absence of toxicity in animals provides little or virtually no evidential weight that adverse drug reactions will also be absent in humans. While our analyses suggest that the presence of toxicity in one species may sometimes add evidential weight for risk of toxicity in another, the LRs are extremely inconsistent, varying substantially for …

An Analysis Of The Use Of Animal Models In Predicting Human Toxicology And Drug Safety, Jarrod Bailey, Michelle Thew, Michael Balls

Jarrod Bailey, PhD

Animal use continues to be central to preclinical drug development, in spite of a lack of its demonstrable validity. The current nadir of new drug approvals and the drying-up of pipelines may be a direct consequence of this. To estimate the evidential weight given by animal data to the probability that a new drug may be toxic to humans, we have calculated Likelihood Ratios (LRs) for an extensive data set of 2,366 drugs, for which both animal and human data are available, including tissue-level effects and MedDRA Level 1–4 biomedical observations. This was done for three preclinical species (rat, mouse …

Consequences Of Developmental Lead (Pb2+) Exposure On Reproductive Strategies In Drosophila, Elizabeth Kathleen Peterson

Legacy Theses & Dissertations (2009 - 2024)

Anthropogenic lead (Pb) pollution is ubiquitous in the environment and a risk factor for both human and wildlife health. Pb exposure has the potential to alter reproductive strategies with respect to mate choice and reproductive output. This could be especially deleterious if these changes disrupt adaptive behavioral and reproductive life history strategies. Therefore, the overall aim of this body of work was to examine the consequences of developmental Pb exposure on reproductive strategies, using Drosophila melanogaster as a model system. In all experiments, D. melanogaster were reared from egg stage to adulthood in either control or leaded medium and were …

Predicting Human Drug Toxicity And Safety Via Animal Tests: Can Any One Species Predict Drug Toxicity In Any Other, And Do Monkeys Help?, Jarrod Bailey, Michelle Thew, Michael Balls

Laboratory Experiments Collection

Animals are still widely used in drug development and safety tests, despite evidence for their lack of predictive value. In this regard, we recently showed, by producing Likelihood Ratios (LRs) for an extensive data set of over 3,000 drugs with both animal and human data, that the absence of toxicity in animals provides little or virtually no evidential weight that adverse drug reactions will also be absent in humans. While our analyses suggest that the presence of toxicity in one species may sometimes add evidential weight for risk of toxicity in another, the LRs are extremely inconsistent, varying substantially for …

Development Of Culturing Methods For Native Mayfly Taxa For Use In Laboratory Toxicity Testing, Kevin Nicholas Rowsey

Theses, Dissertations and Capstones

Salinity is increasing in freshwaters throughout the world due to anthropogenic impacts with the implication of the increases to biological communities only now being realized. Declining mayfly populations in Appalachian streams have generated increased interest in elevated dissolved solids in that region and their effect on benthic macroinvertebrates, particularly the sensitive Ephemeroptera taxa. Field and laboratory evaluations have indicated high sensitivity of mayflies to elevated dissolved solids. The research described herein is part of an ongoing effort to provide opportunity for toxicity testing with native mayflies in the laboratory. A successful endeavor would establish mayfly sensitivity to total dissolved solids …

The Neurobehavioral Consequences Of Gestational And Chronic Atrazine Exposure In Male And Female Sprague Dawley Rats, Jennifer L. Walters

Dissertations

The adverse health risks of exposure to the herbicide, atrazine, in humans are not fully understood. Although numerous studies have demonstrated atrazine to be an endocrine disrupter, the neurobehavioral consequences of atrazine exposure have not been thoroughly examined. The aim of this study was to investigate the effects of environmentally-relevant levels

of gestational followed by continued chronic atrazine exposure on motor function, learning and memory, anxiety, and striatal dopamine content in rodents. Pregnant Sprague Dawley rats were treated by gavage with 100 µg/kg atrazine (ATZ low), 10 me/kg atrazine (ATZ high), or vehicle on

gestational day l through postnatal day …

An Analysis Of The Use Of Animal Models In Predicting Human Toxicology And Drug Safety, Jarrod Bailey, Michelle Thew, Michael Balls

Experimentation Collection

Animal use continues to be central to preclinical drug development, in spite of a lack of its demonstrable validity. The current nadir of new drug approvals and the drying-up of pipelines may be a direct consequence of this. To estimate the evidential weight given by animal data to the probability that a new drug may be toxic to humans, we have calculated Likelihood Ratios (LRs) for an extensive data set of 2,366 drugs, for which both animal and human data are available, including tissue-level effects and MedDRA Level 1–4 biomedical observations. This was done for three preclinical species (rat, mouse …

An Analysis Of The Use Of Dogs In Predicting Human Toxicology And Drug Safety, Jarrod Bailey, Michelle Thew, Michael Balls

Laboratory Experiments Collection

Dogs remain the main non-rodent species in preclinical drug development. Despite the current dearth of new drug approvals and meagre pipelines, this continues, with little supportive evidence of its value or necessity. To estimate the evidential weight provided by canine data to the probability that a new drug may be toxic to humans, we have calculated Likelihood Ratios (LRs) for an extensive dataset of 2,366 drugs with both animal and human data, including tissue-level effects and Medical Dictionary for Regulatory Activities (MedDRA) Level 1–4 biomedical observations. The resulting LRs show that the absence of toxicity in dogs provides virtually no …

Lokta’S Law Revisited In Toxicology Literature, Mini Devi B

Library Philosophy and Practice (e-journal)

The article highlights the significance of Lotka’s Inverse Square Law of Scientific Productivity in today’s information age and later studies. The classical law is applied to Toxicology literature collected from the international database, Toxicology Information Online (TOXLINE), and its validity on that data was tested. The data was found unfit for the law Hence a new formula is derived, , was found fit for the study.

Agenda: Air Quality Impacts From Oil And Gas Development, University Of Colorado Boulder. Natural Resources Law Center

Air Quality Impacts from Oil and Gas Development (January 27)

Oil and gas development and hydraulic fracturing have received enormous attention over the past few years, and most of that attention has focused on the potential impacts of such development on water quality. However, the potential impacts on air quality from oil and gas development have received far less public and media attention and discussion. This two-hour program will assess the current scientific knowledge, regulatory requirements and policies regarding the impacts on air quality from oil and gas development and will address current initiatives at the state and national levels to further regulate and control those impacts.

Toxicology And New Social Ethics For Animals, Bernard E. Rollin

Experimentation Collection

The issue of animal treatment has emerged as a major social concern over the past three decades. This ramified in a new ethic for animal treatment that goes beyond concern about cruelty and attempts to eliminate animal pain and suffering, whatever its source. This is evidenced by laws governing animal research in many countries. Insofar as toxicology can entail significant and prolonged animal suffering, it is at loggerheads with this new ethic. Ways are suggested for the toxicological community to put itself in harmony with the ethic and thereby preserve its autonomy.

Evolution Of Chemical Contaminant And Toxicology Studies, Part 2- Case Studies Of Selenium And Arsenic, Glennys O'Brien, Dianne Jolley, Robert John Morrison

Faculty of Science - Papers (Archive)

As the second of a two part series discussing the evolution of the field of environmental toxicology, this paper presents two case studies: selenium and arsenic. Developments over several decades in the understanding of the behaviour of arsenic and selenium in different chemical forms in various compartments of the environment are discussed. Selenium was initially thought to be toxic, but later investigations showed it to be an essential micronutrient with a variety of biochemical functions, and, importantly, that there is a very narrow gap between the essential and the toxic body burden. Arsenic, on the other hand, has not yet …