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2026

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Full-Text Articles in Social and Behavioral Sciences

Development Of The Simultaneous Alcohol And Cannabis Use Expectancy Questionnaire (Sac-Eq), Shane D. Marohnic Jan 2026

Development Of The Simultaneous Alcohol And Cannabis Use Expectancy Questionnaire (Sac-Eq), Shane D. Marohnic

Graduate Studies Theses and Dissertations 2026

Background: Simultaneous alcohol and cannabis use (SAC/SAM), defined as using alcohol and cannabis at the same time so that their effects overlap, has been identified as a hazardous form of polysubstance use. Expectancies are a causal mechanism and can be changed with predictable reductions in substance use and associated consequences, yet only one measure has been developed to assess expectancies related to SAC. Due to limitations of the existing measure, this study sought to create a more comprehensive SAC expectancy scale. Method: Three phases of participants (Phase 1, N = 493; Phase 2, n = 4; Phase 3, n …


Human-Centered Governance Of Climate Resilience: Integrating Sustainability, Equity, And Mental Health, Chelcee A. Pangerl Jan 2026

Human-Centered Governance Of Climate Resilience: Integrating Sustainability, Equity, And Mental Health, Chelcee A. Pangerl

Graduate Studies Theses and Dissertations 2026

This dissertation examines how sustainability and resilience are defined, implemented, and experienced across three levels of climate governance: household perception, community experience, and federal policy. Climate resilience is often evaluated through infrastructure performance, emissions targets, restoration timelines, and preparedness systems, yet these measures do not fully capture how residents experience uncertainty, support, equity, and mental health. To address this gap, the dissertation develops and applies the Integrated Policy Framework for Sustainability and Resilience (IPFSR). IPFSR organizes six domains into three functional categories: policy outcomes, human-centered dimensions, and implementation mechanisms. Sustainability and operational/physical resilience are treated as policy outcomes; mental health …


I, Cock-A-Doodle-Do: Reclaiming Masculinity Through Queer Joy And Humorous Self-Exploration, Nelson J. Garcia Jan 2026

I, Cock-A-Doodle-Do: Reclaiming Masculinity Through Queer Joy And Humorous Self-Exploration, Nelson J. Garcia

Graduate Studies Theses and Dissertations 2026

I examine the contemporary norms of masculinity. My research wrestles with ultimately unresolvable stereotypes and imagery influencing current masculine behavior. I unearth queer potential through the physicality and behavior of the stereotypical “man’s man”. I infuse my own queer identity into my studio practice with an emphasis on humor and joy to subvert traditional models of male performance. This process drives self-exploration that allows me to personally respond, react, be directed, and redirected by the interactions between queerness and masculinity. Masculine and queer representations across various media, such as film, music, and television, historically and continuously inform restrictive cultural norms. …


Contested Air: Politics, Prejudice, And Radio Broadcasting In New York State, 1925-1928, Sebastian Garcia Jan 2026

Contested Air: Politics, Prejudice, And Radio Broadcasting In New York State, 1925-1928, Sebastian Garcia

Graduate Studies Theses and Dissertations 2026

This thesis examines the intersection between radio broadcasting as the "new media" of the 1920s and American political culture of the period, using New York Governor and 1928 Democratic presidential candidate Alfred E. Smith as a case study. Smith entered 1925 as a political lone wolf and left the year as a triumphant victor set to take the presidency. Building on the work of Smithian scholars, this thesis illuminates how Smith’s radio use remained central to this political transformation. Smith found in radio an apt space to bypass Republican opposition and mobilize the body politic through direct engagement, which, in …


Emotional Support Friends: Creating Social Impact Through Art And Polite Humor, Kenyari Gil Rosario Jan 2026

Emotional Support Friends: Creating Social Impact Through Art And Polite Humor, Kenyari Gil Rosario

Graduate Studies Theses and Dissertations 2026

This thesis aims to provide new imagery to the conversation of mental health and neurodivergence. It does this through forms of soft sculpture, digital paintings, marker drawings, and community murals. Inspired by the practices of Keith Haring, iconographic characters are used to portray common struggles and coping habits of mental conditions in an endearing light. With the goal of social impact, this project is affiliated with the non-profit organization Providing Autism Links and Support (P.A.L.S). This partnership has given the community an opportunity to share their compassion through art and donations and uses art as a means of social impact …


Centered A Story Of Family And Compassion In The Face Of Parkinson's Disease, Savannah Hill Jan 2026

Centered A Story Of Family And Compassion In The Face Of Parkinson's Disease, Savannah Hill

Graduate Studies Theses and Dissertations 2026

Centered is a three-dimensional (3D) animated short film that explores the topic of parental illness and how families must respond with compassion and adaptability when loved ones face mental or physical challenges. The story is inspired by the director’s own experience with her father’s diagnosis of Parkinson’s Disease when she was in high school. The main characters, a father and daughter, must navigate the father’s changing needs after his diagnosis by prioritizing their connection and adapting to his new physical challenges. In the film, they do this through the creation of pottery. The imperfect, handmade design style of the film …


Essays On Network Resilience: Enhancing Network Resilience Through Network Governance Structure, Process, Environment, And Leadership, Hanvit Kim Jan 2026

Essays On Network Resilience: Enhancing Network Resilience Through Network Governance Structure, Process, Environment, And Leadership, Hanvit Kim

Graduate Studies Theses and Dissertations 2026

As disasters become more complex, their impacts often cascade across interdependent systems, creating failures that extend beyond any single organization or sector. Because such crises cut across organizational and sectoral boundaries, effective response depends not only on the capacity of individual organizations but also on the resilience of interorganizational networks. Yet despite the growing importance of networked coordination in disaster response, the concept of network resilience remains underdeveloped in the literature, with limited consensus on its definition, measurement, and determinants. This dissertation addresses that gap by systematically examining what network resilience is, how it can be conceptualized and assessed, and …


Do Emerging Social Media Platforms Shape The Gender Gap In Surveillance Political Knowledge?, Saskia Papsova Jan 2026

Do Emerging Social Media Platforms Shape The Gender Gap In Surveillance Political Knowledge?, Saskia Papsova

Graduate Studies Theses and Dissertations 2026

Abstract

Research shows that men consistently score higher than women on standard political knowledge measures, but as Americans increasingly obtain political information through social media, it is unclear whether different platforms affect this gender gap. This study investigates whether social media platforms shape the gender gap in surveillance political knowledge—knowledge of current political facts and contested claims circulating in the contemporary information environment, and which platforms have the biggest impact. Using data from the ANES 2020 Social Media Study, I estimate weighted OLS regression models testing whether platform-specific usage is associated with surveillance political knowledge and whether these associations differ …


Modeling Hazard Perception Learning In Novice Drivers With Autism: A Multimodal Simulation-Based Study, Erik J. Sand Jan 2026

Modeling Hazard Perception Learning In Novice Drivers With Autism: A Multimodal Simulation-Based Study, Erik J. Sand

Graduate Studies Theses and Dissertations 2026

Young drivers with autism spectrum disorder (ASD) often demonstrate difficulties with road-surveillance behaviors such as scanning ahead, monitoring mirrors, and identifying emerging hazards. These challenges can increase crash risk, particularly for adolescents with limited driving experience. This study explored whether a simple, video-game–based hazard-training program could improve hazard detection performance, visual scanning, and self-regulation in this population. Five participants aged 15–18 years, each identified by a parent as having ASD and possessing either a learner’s permit or no license, completed sequential Baseline, three Treatment, and Withdrawal phases using the SpeedLimit driving simulation. The study employed a single-case experimental design with …


Rhetoric Of Opportunity: An Analysis Of Gullah Geechee Histories Through The Lens Of Counterstory, Xaria Arthur Jan 2026

Rhetoric Of Opportunity: An Analysis Of Gullah Geechee Histories Through The Lens Of Counterstory, Xaria Arthur

Graduate Studies Theses and Dissertations 2026

Counterstory as a method/ology has been used in a variety of disciplines to share experiences of individuals and communities whose voices have been historically silenced or suppressed. Utilizing this methodological framework, my study shares the stories of six Gullah Geechee descendants with ancestral roots in the unincorporated community of Nesmith in Williamsburg County, SC. Treating these minoritized and individual stories as experiential knowledge, I trace the counterstories as topoi to introduce and develop the theoretical concept that I call the rhetoric of opportunity, which refers to memories or stories that have come to motivate individuals toward or away from …


Essays On Politics And Ideology In Asset Management, Madison Borrelli Jan 2026

Essays On Politics And Ideology In Asset Management, Madison Borrelli

Graduate Studies Theses and Dissertations 2026

This dissertation examines how political influence and ideology shape the investment and governance decisions of institutional investors. My first essay studies the effects of political interference on public pension plan asset allocation. Plans facing investment restrictions shift away from low-cost traditional assets toward higher-fee, lower-performing alternative assets. While politicians advocating these restrictions receive increased media attention, state economies do not benefit. These findings underscore how political incentives create agency problems that adversely affect investment decisions and outcomes.

The second essay examines whether differences in political ideology between asset managers and investors give rise to conflicts of interest. Mutual fund institutions …


Do Fair Schedules Matter? Work-Home Conflict And Justice In Emergency Medicine, Maresca J. Brand Jan 2026

Do Fair Schedules Matter? Work-Home Conflict And Justice In Emergency Medicine, Maresca J. Brand

Graduate Studies Theses and Dissertations 2026

Emergency physicians work in a high-demand environment requiring irregular, around-the-clock schedules, which can contribute to elevated work-home conflict and burnout. While previous research has focused on objective schedule characteristics such as length of shift or time of day worked, less attention has been given to how emergency physicians perceive the fairness of the scheduling process itself. Drawing on Work-Home Resources Theory and Personal Resource Allocation Theory, this study examines whether perceptions of schedule justice influence work-home conflict via schedule satisfaction. I propose that perceived fairness in schedule creation functions as a contextual resource that shapes whether a schedule is experienced …


Examining Team Leader Visual Dynamics And Team Performance In Pediatric Emergency Simulations, Annamarie Brosnihan Jan 2026

Examining Team Leader Visual Dynamics And Team Performance In Pediatric Emergency Simulations, Annamarie Brosnihan

Graduate Studies Theses and Dissertations 2026

Pediatric medical emergencies are dynamic, high-intensity clinical situations that demand coordinated interdisciplinary actions for optimal patient outcomes. Effective teamwork and leadership are critical, especially during the preparatory phase. Here, team leaders define task goals, assign individual roles, and maintain situational awareness. This phase directs attention, organizes team dynamics, and ensures medical interventions are deployed properly. Medical simulations provide a unique opportunity to capture dynamic leadership behaviors in a controlled low-stakes environment using multimodal data, such as eye tracking, to gain insight into team leader cognitive processes (i.e., attention allocation and information processing). Prior research suggests that leaders who visually attend …


The Bite Model And Multi-Level Marketing: How Monat Propagates, Lilly D. Cheung Jan 2026

The Bite Model And Multi-Level Marketing: How Monat Propagates, Lilly D. Cheung

Graduate Studies Theses and Dissertations 2026

This study aims to understand how MONAT Global Corp, a Multi-Level Marketing (MLM) company, utilizes rhetoric that aligns with Steven Hassan’s BITE Model of Authoritarian Control. Hassan is a cult expert and cult survivor whose work primarily explains undue influence and thought control with BITE representing Behavior, Information, Thought, and Emotional control. The MLM MONAT is a haircare brand that operates through a recruitment-and-sales-based hierarchy, in which sellers sign up and work under one another in a layered marketing structure. To meet quotas and maintain ranks, representatives will use rhetorical strategies to recruit new sellers beneath them in their ‘downline’ …


Reliability Of Staged Maximal Aerobic Capacity Protocol Using A Combined Upper- And Lower-Body Air-Braked Ergometer, Jack J. Livingston Jan 2026

Reliability Of Staged Maximal Aerobic Capacity Protocol Using A Combined Upper- And Lower-Body Air-Braked Ergometer, Jack J. Livingston

Graduate Studies Theses and Dissertations 2026

Maximal oxygen uptake (VO₂max) is widely recognized as the preeminent measure of aerobic capacity and is typically assessed using graded exercise testing (GXT). This study examined the test–retest reliability of VO₂peak and associated physiological responses during a staged GXT performed on a combined upper- and lower-body air-braked ergometer. Fifteen recreationally active adults (9 males, 6 females; age: 26.9 ± 7.2 years; body mass: 75.1 ± 11.0 kg) completed one familiarization session and two trials separated by ≥72 hours. Participants performed a staged GXT (40 RPM start, +3 RPM every 3 min to exhaustion) on a combined upper- and lower-body air-braked …


Detecting Error In Ai-Generated Text: The Effects Of Authorship And Word Presentation Speed, Gabriela Flores Cruz Jan 2026

Detecting Error In Ai-Generated Text: The Effects Of Authorship And Word Presentation Speed, Gabriela Flores Cruz

Graduate Studies Theses and Dissertations 2026

The increased us of artificial intelligent (AI) chatbots powered by Generative Pre-trained Transformers has raised concerns about users’ ability to detect errors of AI-generated text. This dissertation examined how readers identify inconsistencies in AI-generated expository passages using the inconsistency detection paradigm from comprehension monitoring research. Across two experiments, it investigated whether perceived authorship and word presentation speed influenced inconsistency detection. Experiment 1 used a 3 (author: human, AI, no author) × 2 (inconsistency type: internal, external) between-subjects design. Perceived authorship did not significantly affect hit rates, sensitivity, or response bias. Exploratory analyses indicated that reading comprehension and working memory predicted …


Cracking The Code Of Ai Autonomy: Examining The Role Of Challenge And Hindrance Appraisals And Ai Literacy In Task Satisfaction, Rujuta Parekar Jan 2026

Cracking The Code Of Ai Autonomy: Examining The Role Of Challenge And Hindrance Appraisals And Ai Literacy In Task Satisfaction, Rujuta Parekar

Graduate Studies Theses and Dissertations 2026

AI is constantly evolving and being rapidly integrated into the workplace. Limited research has examined how this integration is affecting employee outcomes, and particularly the impacts of whether employees are expected or mandated to use AI for their work. The present study utilized the challenge-hindrance framework to examine the effect of autonomy in using AI on task satisfaction through challenge and hindrance appraisal among working adults. Since the ability to understand and use AI can influence how individuals perceive it, the moderating effect of AI literacy on the hypothesized research model is also examined. A multi-wave research design was used …


Perspectives Of Poetry: Peering Into Poetry And Aphasia, Kristian M. Perez Jan 2026

Perspectives Of Poetry: Peering Into Poetry And Aphasia, Kristian M. Perez

Graduate Studies Theses and Dissertations 2026

People with aphasia often experience significant barriers to communication, emotional expression, and participation in meaningful life activities following stroke or neurological injury. Although poetry and creative expression have been explored in broader therapeutic contexts, limited research has examined how people with aphasia perceive poetry. The purpose of this qualitative study was to explore the perspectives of people with aphasia regarding definitions of poetry, level of interest in poetry and the factors influencing said interest. Semi-structured interviews were conducted with adults with aphasia recruited through convenience sampling. Participants responded to questions before and after exposure to the poem Trust by Mark …


“I Call For The Resurgence And Reclamation Of Our Indigenous Ways”: Institutional Landscapes, Resistance, And The Experiences Of Mmir Advocates, Sara Tehrani Jan 2026

“I Call For The Resurgence And Reclamation Of Our Indigenous Ways”: Institutional Landscapes, Resistance, And The Experiences Of Mmir Advocates, Sara Tehrani

Graduate Studies Theses and Dissertations 2026

Indigenous Peoples across Turtle Island experience disproportionately high rates of violence and homicide compared to other racial groups. Rooted in coloniality and sustained by Western institutions, this epidemic is recognized as the Missing and Murdered Indigenous Relatives (MMIR) crisis. In response, Indigenous women have mobilized the MMIR Movement to raise awareness and advocate for institutional change. Although scholarship on MMIR has expanded, limited research has explored the experiences of MMIR advocates. This study interrogates the institutional landscapes that shape MMIR advocacy and explores the resistance strategies advocates employ to address the crisis. Using reflexive thematic analysis, this study examines semi-structured …


Symmetry, Presumptions, And The Judges Design, Murat C. Mungan Jan 2026

Symmetry, Presumptions, And The Judges Design, Murat C. Mungan

Faculty Scholarship

An instrumental variables approach called ‘the judges design’ used frequently in social sciences relies on an assumption called ‘average monotonicity’. This assumption pertains to how different judges’ (or other classifiers’) decision making processes relate to each other. Violations of it are hard to detect, which raises the importance of it being supported by a plausible theory. Decisions of judges who solve Bayesian decision problems violate average monotonicity as long as the signals they process are symmetric and they do not possess strong presumptions. This result is extended to cases where judge presumptions are symmetrically distributed and may include strong presumptions. …


The 2026 World Cup, In Trump’S Shadow, Richard Holtzman Jan 2026

The 2026 World Cup, In Trump’S Shadow, Richard Holtzman

History, Literature, and the Arts Faculty Journal Articles

This essay examines President Donald Trump’s rhetorical interventions in the lead-up to the 2026 FIFA World Cup. It is inspired by Eduardo Galeano’s Soccer in Sun and Shadow, which interprets football as a mirror reflecting broader political, cultural, and economic realities. My analysis explores how Trump commandeered the World Cup through spectacle, transforming it into a stage for symbolically demonstrating his power and indulging his ego. The president’s rhetorical behavior is explored and critiqued through three case studies and a final vignette: (1) the establishment of a White House World Cup Task Force, (2) the president’s threats to relocate …


Strategic Decoupling: How Great Power Competition Reshapes Domestic Economic Policy In The United States And China, Chick Edmond Jan 2026

Strategic Decoupling: How Great Power Competition Reshapes Domestic Economic Policy In The United States And China, Chick Edmond

Political Science & Geography Faculty Publications

Objectives:
The core idea of this research is that states react to great-power competitions using institutionally dependent paths: the U.S. uses regulatory tools such as export controls, investment screening, and targeted subsidies based on its fragmented, legally mediated-governance structure; whereas, China uses state-driven tools such as central planning directives, State-Owned Enterprise (SOE) mandates, and Policy Bank lending driven by its hierarchical Party-State structure

Methods:
This research utilizes a qualitative comparative case study model to compare how the U.S. and China have developed different forms of domestic economic policy in reaction to competing interests of being a global superpower. A comparative …


Affordable Course Content And Open Education Resources For Undergraduate Courses Teaching Fundamentals Of Wireless Communications And Networking, Dimitrie C. Popescu, Otilia Popescu Jan 2026

Affordable Course Content And Open Education Resources For Undergraduate Courses Teaching Fundamentals Of Wireless Communications And Networking, Dimitrie C. Popescu, Otilia Popescu

Electrical & Computer Engineering Faculty Publications

Wireless communication systems and networks along with the services they provide have become an essential component of the modern 21st century society, fueling job growth in the wireless industry and increasing the need for engineers specialized in wireless communication systems. As a consequence, over the past two decades, undergraduate courses teaching fundamentals of wireless communication systems and networks have become common in electrical and computer engineering and technology programs. At the same time, the number of textbooks dedicated to wireless systems and networks published by mainstream publishers has also grown, with availability in various formats and offerings and a significant …


Statewide Corridor Evacuation Response And Re-Entry Behaviors In Florida During Hurricane Irma, Xin Wang, Yuan Zhu, Hong Yang, Kun Xie Jan 2026

Statewide Corridor Evacuation Response And Re-Entry Behaviors In Florida During Hurricane Irma, Xin Wang, Yuan Zhu, Hong Yang, Kun Xie

Electrical & Computer Engineering Faculty Publications

Hurricane Irma stands as one of the most destructive tropical storms to make landfall in the United States, particularly impacting the State of Florida, where it prompted the largest evacuation in history with approximately 7 million residents. The profound consequences of mass evacuation underscore the critical need to understand travel behaviors during hurricane evacuation and the recovery process. This research analyzes statewide evacuation and re-entry patterns, leveraging diverse datasets, including TTMS data from main corridors and GIS data. A statewide corridor-based empirical analysis framework is constructed to characterize evacuation and re-entry response patterns using sensor-based traffic observations. The results show …


Neighborhood Socioeconomic Deprivation And Physical Activity Associate With Extracellular Vesicle Size And Cargo In A Community-Based Cohort Of Women, Yvonne Baumer, Elizabeth M. Aquino Peterson, Matthew R. Bavuso, Noel Miller, Cristhian A. Gutierrez-Huerta, Nithya P. Vijayakumar, Sam J. Neally, Kaveri Curlin, Valerie M. Mitchell, Billy S. Collins, Neelam R. Redekar, Subrata Paul, Anca D. Dobrian, Tiffany M. Powell-Wiley Jan 2026

Neighborhood Socioeconomic Deprivation And Physical Activity Associate With Extracellular Vesicle Size And Cargo In A Community-Based Cohort Of Women, Yvonne Baumer, Elizabeth M. Aquino Peterson, Matthew R. Bavuso, Noel Miller, Cristhian A. Gutierrez-Huerta, Nithya P. Vijayakumar, Sam J. Neally, Kaveri Curlin, Valerie M. Mitchell, Billy S. Collins, Neelam R. Redekar, Subrata Paul, Anca D. Dobrian, Tiffany M. Powell-Wiley

Department of Biomedical and Translational Sciences Faculty Publications

African American (AA) women face disproportionate cardiovascular disease (CVD) risk due to adverse social determinants of health (SDoH), including lower socioeconomic status (SES). Physical activity (PA) and plasma extracellular vesicles (EVs) modulate CVD risk, but their relationships with SDoH remain unclear. This study examines associations between SDoH, PA, and plasma EVs in a Washington, DC-based cohort of at-risk AA women. Participants (N = 24, Age: 57 ± 12, BMI: 35 ± 6, ASCVD: 9 ± 5) joined the Step It Up Community-Engaged, Digital Health Physical Activity Intervention pilot study. EVs were isolated from fasting plasma samples. Multivariable regression, adjusted for …


The Interplay Between Loneliness, Cortisol, And Nk Cell Function: The Role Of Cortisol In Nk Cell Dysfunction, Abhinav Saurabh, Yvonne Baumer, Laurel G. Mendelsohn, Elizabeth M. Aquino Peterson, Dana Sadler, Shirley J. Lopez De Leon, Ayushi Dave, Andrew S. Baez, Lola R. Ortiz-Whittingham, Mario A. Pita, Manuel A. Cintron, Hannatu A. Tarfa, Sandy T. Reynolds, Shelby R. Hicks, Sonal Sharda, J. Eleanor Seo, Maria Lopez-Ocasio, Pradeep K. Dagur, Skyler A. Kuhn, Neelam R. Redekar, James F. Troendle, Ayanna L. Wells, Marie Marah, Katherine J. Tolentino, Michael J. Corley, Alika K. Maunakea, Lynnette K. Nieman, Marcus R. Andrews, Tiffany M. Powell-Wiley Jan 2026

The Interplay Between Loneliness, Cortisol, And Nk Cell Function: The Role Of Cortisol In Nk Cell Dysfunction, Abhinav Saurabh, Yvonne Baumer, Laurel G. Mendelsohn, Elizabeth M. Aquino Peterson, Dana Sadler, Shirley J. Lopez De Leon, Ayushi Dave, Andrew S. Baez, Lola R. Ortiz-Whittingham, Mario A. Pita, Manuel A. Cintron, Hannatu A. Tarfa, Sandy T. Reynolds, Shelby R. Hicks, Sonal Sharda, J. Eleanor Seo, Maria Lopez-Ocasio, Pradeep K. Dagur, Skyler A. Kuhn, Neelam R. Redekar, James F. Troendle, Ayanna L. Wells, Marie Marah, Katherine J. Tolentino, Michael J. Corley, Alika K. Maunakea, Lynnette K. Nieman, Marcus R. Andrews, Tiffany M. Powell-Wiley

Department of Biomedical and Translational Sciences Faculty Publications

Chronic psychosocial stressors contribute to cardiovascular disease (CVD) and related risk factors, particularly in under-resourced communities. Psychosocial stressors activate the hypothalamic-pituitary-adrenal (HPA) axis, leading to sustained cortisol action on immune cells. Natural killer (NK) cells are altered in distribution and function in cardio-metabolic diseases; however, pathways linking cortisol as a marker of chronic stress to NK cell dysfunction remain understudied. We recruited 186 African American women from the Step It Up Community-Engaged, Digital Health Physical Activity Intervention study and collected cortisol, NK cell measures, and psychosocial stress measures using validated questionnaires, including chronic stress and loneliness. Plasma cortisol levels were …


The Effects Of Abused Drugs On Ferroptosis Pathways: Potential Therapeutic Targets For Substance Use Disorders, Tamara Bouchard, Brooke Russell, Liam Liyang Guo, Tina Nguyen, Yan Cheng, Yan Y. Sanders, Ming-Lei Guo Jan 2026

The Effects Of Abused Drugs On Ferroptosis Pathways: Potential Therapeutic Targets For Substance Use Disorders, Tamara Bouchard, Brooke Russell, Liam Liyang Guo, Tina Nguyen, Yan Cheng, Yan Y. Sanders, Ming-Lei Guo

Department of Biomedical and Translational Sciences Faculty Publications

Substance use disorders (SUDs) remain major public health concerns worldwide, particularly in developed countries. SUDs are characterized by persistent neuroinflammation and synaptic dysfunction in the brain. Despite decades of extensive investigation, the detailed mechanisms underlying SUDs remain elusive. Ferroptosis is a highly regulated cell death process deeply affected by iron metabolism, lipid peroxidation, reactive oxygen species (ROS) production, and antioxidant systems. It has been implicated in multiple neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and ischemic stroke. Recently, emerging evidence has highlighted the role of ferroptosis in drug-induced pathological changes. Various types of abused …


Yk-4-250, A Synthetic Telmisartan-Tempol Conjugate: Crystal Structure Of A Stabilized Free Radical Containing An Angiotensin At₁ Receptor Inhibitor, Simon Friedrich, Yali Kong, Faik N. Musayev, Milton L. Brown, B. Frank Gupton Jan 2026

Yk-4-250, A Synthetic Telmisartan-Tempol Conjugate: Crystal Structure Of A Stabilized Free Radical Containing An Angiotensin At₁ Receptor Inhibitor, Simon Friedrich, Yali Kong, Faik N. Musayev, Milton L. Brown, B. Frank Gupton

Department of Biomedical and Translational Sciences Faculty Publications

We report the first crystal structure of the telmisartan-tempol conjugate 2,2,6,6-tetramethyl-1-(λ'-oxidaneyl)piperidin-4-yl 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl]-[1,1'-biphenyl]-2-carboxylate free radical (YK-4-250, C₄₂H₄₆N₅O₃), a dual-function inhibitor designed to target both the angiotensin II type 1 receptor (AT₁R) and reactive oxygen species (ROS). Structural analysis reveals a unique crystal architecture in which the nitroxide radical is stabilized within a sterically protected environment while preserving the telmisartan pharmacophore essential for high-affinity receptor antagonism. YK-4-250 is a novel small-molecule conjugate of telmisartan and tempol that incorporates a catalytic stabilized nitroxide radical and was rationally designed to mitigate gastrointestinal acute radiation syndrome (GI-ARS).


Resilient Built Environment: An Overview On Design Strategies For Coastal Adaptation To Sea Level Rise, Farzaneh Soflaei, Gelareh Abdolzadeh, Navid Ziaee, Mohammad Amin Jafari, Faeghe Borhani Jan 2026

Resilient Built Environment: An Overview On Design Strategies For Coastal Adaptation To Sea Level Rise, Farzaneh Soflaei, Gelareh Abdolzadeh, Navid Ziaee, Mohammad Amin Jafari, Faeghe Borhani

Civil & Environmental Engineering Faculty Publications

This paper delves into the escalating risks faced by urban coastal communities due to tidal and storm flooding, exacerbated by climate change-induced Sea Level Rise (SLR). Projections indicate a potential increase in sea levels by at least 3 feet by 2100, with historical data revealing an average annual rise of 1.2-1.7 mm since the 1900s. With over 300 million individuals inhabiting coastal areas, low-lying regions emerge as particularly vulnerable to the impacts of SLR. This accelerated rise amplifies the significant challenge of nuisance flooding, a local-scale issue aggravated by high tide and winds, leading to inundation, road closures, infrastructure deterioration, …


Physics-Based Multi-Hazard Fragility Modeling Of Low-Rise Wood-Frame Buildings Under Hurricane-Induced Wind And Surge, Mumtasirun Nahar, Abdullah M. Braik, Mohammad Syed, Maria Koliou, Petros Sideris Jan 2026

Physics-Based Multi-Hazard Fragility Modeling Of Low-Rise Wood-Frame Buildings Under Hurricane-Induced Wind And Surge, Mumtasirun Nahar, Abdullah M. Braik, Mohammad Syed, Maria Koliou, Petros Sideris

Civil & Environmental Engineering Faculty Publications

Coastal buildings are exposed to concurrent hurricane-induced wind and storm surge, yet their vulnerability is commonly assessed using separate single-hazard models that neglect hazard interaction. This study developed a physics-based finite element framework to evaluate the performance of a low-rise light wood-frame building under simultaneous wind and surge-wave loading. A detailed three-dimensional model was constructed using a sub-assembly strategy that explicitly represented framing members, sheathing systems, and critical connections. Structural response was evaluated across a hazard space defined by wind speed, still-water depth, and flow velocity, and component- and system-level fragility functions were derived using Monte Carlo simulation and generalized …