Social and Behavioral Sciences Commons^™

Specialization Or Diversification? Creators’ Strategies On User-Generated Content Platforms, Ziwei Ye

Theses and Dissertations in Business Administration

Recent advancements in digital platforms have reshaped content creation and distribution. User-generated content (UGC), created and shared by internet users, is transforming entertainment, communication, and information sharing. The rise of UGC has fueled the growth of the "creator economy"—an ecosystem of creators, users, and advertisers facilitated by platforms such as YouTube and TikTok. While prior research has primarily explored how UGC platforms incentivize content quantity and quality, this study advances the literature by examining how creators' content strategies influence consumer attention and how platform mechanisms shape this relationship, offering new insights into the interplay between creator behavior and platform design. …

Thriving In The Age Of Ai: Navigating Ai Identity Threat Through Ai Job Crafting, Yuming He

Theses and Dissertations in Business Administration

As artificial intelligence (AI) technologies like GenAI tools increasingly reshape the workplace, employees increasingly face threats to their work identity. Grounded in the identity threat response model and job crafting theory, this study investigates how AI identity threat influences employee AI job crafting behaviors and how these behaviors, in turn, affect vitality and learning. Using survey data from 521 full-time employees who actively engage with AI tools, the results indicate that AI identity threat stimulates both AI approach job crafting and AI avoidance job crafting. AI approach crafting enhances both vitality and learning, while AI avoidance crafting only supports vitality. …

Community Safety Innovations: New York State Initiatives To Strengthen Public Safety, Justice D. Evans, Elia Del Carmen Solano-Patricio, Rebecca Balletto, Kathleen A. Tomberg, Jeffrey A. Butts

Publications and Research

This report presents findings from researchers at the Research and Evaluation Center at John Jay College (JohnJayREC) regarding the impact of state investments in community safety. The report highlights key initiatives such as the SNUG program, Gun Involved Violence Elimination (GIVE), Project RISE, and Crime Analysis Centers (CACs). Through interviews with State agency staff and initiative leaders, the research team gathered valuable insights into the goals, challenges, and implementation of these programs. The findings suggest that these efforts may contribute to reduced violence and enhanced neighborhood safety, though further, more robust evaluation could help refine and expand these efforts for …

Understanding Anti-Racism In Counselor Education: A Narratology Of Anti-Racist Pedagogy In Sociocultural Courses, Danielle G. Rodgers

Counseling & Human Services Theses & Dissertations

Counselors have the privilege to join children, adolescents, and adults from all walks of life in a journey of working towards mental and emotional wellness. Our code of ethics outlines “honoring diversity and embracing a multicultural approach in support of the worth, dignity, potential, and uniqueness of people within their social and cultural contexts” (p.3) and promoting social justice as two of our core professional values (American Counseling Association [ACA], 2014). The ACA also stated in their Antiracist Statement in 2020 that “we have a moral and professional obligation to deconstruct institutions which have historically been designed to benefit White …

Benchmarking Empirical Severity For The Yale-Brown Obsessive Compulsive Scale-Second Edition, Caitlin M. Pinciotti, Juliana Avery, Chencheng Zhang, Josselyn S. Muñoz, Dayan Berrones, Vanessa Zavala Cruz, Andrew D. Wiese, Jacey L. Anderberg, Isabella A. Cruz, Joseph D. Hovey

Psychological Science Faculty Publications

The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) is considered the primary instrument for assessing the presence and severity of obsessive-compulsive disorder (OCD). Conceptual and empirical critiques inspired the development of an updated version of the instrument, the Yale-Brown Obsessive Compulsive Scale-Second Edition (Y-BOCS-II), with a higher ceiling of OCD severity to better differentiate between severe and the most debilitating OCD presentations, among other revisions. The Y-BOCS-II has demonstrated sound psychometric properties across diverse samples. Empirically derived severity benchmarks have been proposed for the original Y-BOCS, yielding somewhat different ranges than what has been commonly used in clinical and research settings, yet …

Handling Socio-Institutional Traps–Inertia Towards Australia’S Resilient International Development Aid Programs In The Solomon Islands, Mark Opoku Amankwa, Kwadwo Adusei-Asante, Alina Novak

Research outputs 2022 to 2026

This study critically examines how donor’s aid delivery approach, entrenched socio-institutional dynamics, and the Solomon Islands’ complex political economy create persistent barriers to Australia’s aid programming. Through a desktop research approach, institutional trap–inertia theory is applied to analyze how Australia’s aid efforts and political structures perpetuate aid inertia. The study critiques both Australia’s aid delivery approach and the internal governance challenges in a cohesive society of the SI, highlighting their intertwined roles in impeding Australia’s aid programming. The article proffers context-driven, locally adaptive strategies aimed at overcoming institutional traps and fostering more resilient and effective aid interventions.

A Comprehensive Science Mapping Of Tourism And Hospitality Research: Tribes, Territories And Networks, Songshan (Sam) Huang

Research outputs 2022 to 2026

This study aims to provide a comprehensive bibliographic analysis of the field of tourism and hospitality research by mapping the contributions of researchers, research institutions and evolution of research topics and collaboration networks. Metadata from 27 SSCI and 30 ESCI tourism and hospitality journals were collected from Web of Science. Data analysis was conducted utilizing R package of Bibliometrix and Biblioshiny, adhering to the guidelines of bibliometric analysis. The study identified topics of sustainability and IT technology applications in tourism and hospitality as the recent research fronts. An increasing number of Chinese origin researchers emerged in the author collaboration network, …

Synthesis Of Publications On The Anomalous June 2021 Heat Wave In The Pacific Northwest Of The United States And Canada, Erica Fleishman, David E. Rupp, Paul C. Loikith, Karin A. Bumbaco, Larry W. O'Neill

Geography Faculty Publications and Presentations

We synthesized more than 70 articles, most peer reviewed, that addressed the heat wave that occurred across the Pacific Northwest of the United States and Canada in late June 2021, breaking hundreds of daily and all-time daily maximum temperature records across the region. A persistent, extraordinarily strong ridge of high pressure was a primary driver of the heat wave. Contributing mechanisms were moisture originating in the tropical western Pacific Ocean, high solar radiation, low pressure offshore, large-scale subsidence over land, and unusually dry soils. Climate change contributed to the heat wave’s magnitude by increasing mean temperature, although it is unclear …

A Multi-Site Study Of Clinician Perspectives In The Lifecycle Of An Algorithmic Risk Prediction Tool, Rita Dexter, Kristin Kostick-Quenet, Jennifer Blumenthal-Barby

Center for Medical Ethics and Health Policy Staff Publications

Recent advancements in the performative capacities of artificial intelligence (AI), machine learning (ML), and algorithmic-based tools open up numerous applications in modern medicine. There are, however, few studies that track the whole lifecycle of a digital healthcare tool as it evolves from conception, to design, and deployment in real world settings-especially with a focus on the social dynamics amongst the end-users of the tool: clinicians. In this paper, we present data from a multi-site, 5-year study focused on the development and deployment of an algorithmic risk calculator (HeartMate 3 Risk Score) into a validated and efficacy tested clinical decision support …

Developmental Lead Exposure And Aggression In Male Rats: Influences Of Maternal Care And Environmental Enrichment, Shamaila Zafar, Courtney K. Williams, Jaehyun Joo, Blanca E. Himes, Jay S. Schneider

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Developmental lead (Pb) exposure results in a variety of cognitive deficits and behavioral issues including increased antisocial behavior and aggression. This study investigated the effect of developmental Pb exposure on aggression and violent behavior in male rats and the potential modulatory influences of quality of maternal care and enriched/non-enriched housing conditions. Long-Evans male rats with or without Pb exposure (perinatal or early postnatal) from low or high maternal care mothers (based on amounts of licking/grooming and arched- back nursing) were randomly assigned to live in enriched or non-enriched environments at weaning. At post- natal day 120–190, offensive aggression was assessed …

Increasing Soil Respiration In A Northern Hardwood Forest Indicates Symptoms Of A Changing Carbon Cycle, Angela R. Possinger, Charles T. Driscoll, Mark B. Green, Timothy J. Fahey, Chris E. Johnson, Mary Margaret K. Koppers, Lisa D. Martel, Jennifer L. Morse, Pamela H. Templer, Angelina M. Uribe, Geoffrey F. Wilson, Peter M. Groffman

Environmental Science and Management Faculty Publications and Presentations

Soil carbon dioxide (CO2) flux, or soil respiration, is a critical control on net ecosystem carbon (C) balance. Using long-term (2002-2020) measurements at the Hubbard Brook Experimental Forest (New Hampshire, U.S.), we show that soil respiration rates have notably increased since ~2015. In 2020, cumulative summer respiration flux was approximately 90% higher than the average summer flux over the 2002–2015 period. The increase in soil respiration cannot be explained directly by temperature or pH change alone. We also found that heterotrophic microbial C mineralization and microbial biomass C have also increased rapidly since ~2015, pointing towards an increase in the …

A Meta-Analysis Of Diagnostic Yield And Clinical Utility Of Genome And Exome Sequencing In Pediatric Rare And Undiagnosed Genetic Diseases, Rajshree Pandey, Noemi Fluetsch Brennan, Kalliopi Trachana, Sarah Katsandres, Olaf Bodamer, John Belmont, David L Veenstra, Siyang Peng

Center for Medical Ethics and Health Policy Staff Publications

Purpose: To systematically evaluate the diagnostic yield and clinical utility of genome sequencing (GS) and exome sequencing (ES; genome-wide sequencing [GWS]) in pediatric patients with rare and undiagnosed genetic diseases.

Methods: We conducted a meta-analysis of studies published between 2011 and 2023. To address study heterogeneity, comparative analyses included within-cohort studies using random-effects models.

Results: We identified 108 studies including 24,631 probands with diverse clinical indications. The pooled diagnostic yield among within-cohort studies (N = 13) for GWS was 34.2% (95% CI: 27.6-41.5; I2: 86%) vs 18.1% (95% CI: 13.1-24.6; I2: 89%) for non-GWS, with 2.4-times odds of diagnosis (95% …

Detection Of Enterovirus Rna In Pancreas And Lymphoid Tissues Of Organ Donors With Type 1 Diabetes, Jutta E Laiho, Sami Oikarinen, Sofia Morfopoulou, Maarit Oikarinen, Ashlie Renner, Daniel Depledge, Matthew C Ross, Ivan C Gerling, Judith Breuer, Joseph F Petrosino, Vincent Plagnol, Alberto Pugliese, Antonio Toniolo, Richard E Lloyd, Heikki Hyöty, Npod-Virus Group

Center for Medical Ethics and Health Policy Staff Publications

Aims/hypothesis: The nPOD-Virus group collaboratively applied innovative technologies to detect and sequence viral RNA in pancreas and other tissues from organ donors with type 1 diabetes. These analyses involved the largest number of pancreas samples collected to date. The aim of the current work was to examine the presence of enterovirus RNA in pancreas and lymphoid tissues of organ donors with and without type 1 diabetes.

Methods: We analysed pancreas, spleen, pancreatic lymph nodes and duodenum samples from the following groups: (1) donors with type 1 diabetes (n=71) with (n=35) or without (n=36) insulin-containing islets; (2) donors with single or …

Genome-Wide Analyses Identify 30 Loci Associated With Obsessive-Compulsive Disorder, Nora I Strom, Zachary F Gerring, Marco Galimberti, Dongmei Yu, Matthew W Halvorsen, Abdel Abdellaoui, Cristina Rodriguez-Fontenla, Julia M Sealock, Tim Bigdeli, Jonathan R Coleman, Behrang Mahjani, Jackson G Thorp, Katharina Bey, Christie L Burton, Jurjen J Luykx, Gwyneth Zai, Silvia Alemany, Christine Andre, Kathleen D Askland, Julia Bäckman, Nerisa Banaj, Cristina Barlassina, Judith Becker Nissen, O Joseph Bienvenu, Donald Black, Michael H Bloch, Sigrid Børte, Rosa Bosch, Michael Breen, Brian P Brennan, Helena Brentani, Joseph D Buxbaum, Jonas Bybjerg-Grauholm, Enda M Byrne, Judit Cabana-Dominguez, Beatriz Camarena, Adrian Camarena, Carolina Cappi, Angel Carracedo, Miguel Casas, Maria Cristina Cavallini, Valentina Ciullo, Edwin H Cook, Jesse Crosby, Bernadette A Cullen, Elles J De Schipper, Richard Delorme, Srdjan Djurovic, Jason A Elias, Xavier Estivill, Martha J Falkenstein, Bengt T Fundin, Lauryn Garner, Christina Gironda, Fernando S Goes, Marco A Grados, Jakob Grove, Wei Guo, Jan Haavik, Kristen Hagen, Kelly Harrington, Alexandra Havdahl, Kira D Höffler, Ana G Hounie, Donald Hucks, Christina Hultman, Magdalena Janecka, Eric Jenike, Elinor K Karlsson, Kara Kelley, Julia Klawohn, Janice E Krasnow, Kristi Krebs, Christoph Lange, Nuria Lanzagorta, Daniel Levey, Kerstin Lindblad-Toh, Fabio Macciardi, Brion Maher, Brittany Mathes, Evonne Mcarthur, Nathaniel Mcgregor, Nicole C Mclaughlin, Sandra Meier, Euripedes C Miguel, Maureen Mulhern, Paul S Nestadt, Erika L Nurmi, Kevin S O'Connell, Lisa Osiecki, Olga Therese Ousdal, Teemu Palviainen, Nancy L Pedersen, Fabrizio Piras, Federica Piras, Sriramya Potluri, Raquel Rabionet, Alfredo Ramirez, Scott Rauch, Abraham Reichenberg, Mark A Riddle, Stephan Ripke, Maria C Rosário, Aline S Sampaio, Miriam A Schiele, Anne Heidi Skogholt, Laura G Sloofman, Jan Smit, María Soler Artigas, Laurent F Thomas, Eric Tifft, Homero Vallada, Nathanial Van Kirk, Jeremy Veenstra-Vanderweele, Nienke N Vulink, Christopher P Walker, Ying Wang, Jens R Wendland, Bendik S Winsvold, Yin Yao, Hang Zhou, Estonian Biobank, 23andme Inc, Arpana Agrawal, Pino Alonso, Götz Berberich, Kathleen K Bucholz, Cynthia M Bulik, Danielle Cath, Damiaan Denys, Valsamma Eapen, Howard Edenberg, Peter Falkai, Thomas V Fernandez, Abby J Fyer, J M Gaziano, Dan A Geller, Hans J Grabe, Benjamin D Greenberg, Gregory L Hanna, Ian B Hickie, David M Hougaard, Norbert Kathmann, James Kennedy, Dongbing Lai, Mikael Landén, Stéphanie Le Hellard, Marion Leboyer, Christine Lochner, James T Mccracken, Sarah E Medland, Preben B Mortensen, Benjamin M Neale, Humberto Nicolini, Merete Nordentoft, Michele Pato, Carlos Pato, David L Pauls, John Piacentini, Christopher Pittenger, Danielle Posthuma, Josep Antoni Ramos-Quiroga, Steven A Rasmussen, Margaret A Richter, David R Rosenberg, Stephan Ruhrmann, Jack F Samuels, Sven Sandin, Paul Sandor, Gianfranco Spalletta, Dan J Stein, S Evelyn Stewart, Eric A Storch, Barbara E Stranger, Maurizio Turiel, Thomas Werge, Ole A Andreassen, Anders D Børglum, Susanne Walitza, Kristian Hveem, Bjarne K Hansen, Christian Rück, Nicholas G Martin, Lili Milani, Ole Mors, Ted Reichborn-Kjennerud, Marta Ribasés, Gerd Kvale, David Mataix-Cols, Katharina Domschke, Edna Grünblatt, Michael Wagner, John-Anker Zwart, Gerome Breen, Gerald Nestadt, Jaakko Kaprio, Paul D Arnold, Dorothy E Grice, James A Knowles, Helga Ask, Karin J Verweij, Lea K Davis, Dirk J Smit, James J Crowley, Jeremiah M Scharf, Murray B Stein, Joel Gelernter, Carol A Mathews, Eske M Derks, Manuel Mattheisen

Center for Medical Ethics and Health Policy Staff Publications

Obsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including WDR6, DALRD3 and CTNND1 and multiple genes in the major histocompatibility complex (MHC) region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and the cortex, along …

Why Democracy Has Lost The Trust Of Modern People In The Modern Era, Erica Rubel

University Honors Theses

This thesis examines the growing crisis of democratic legitimacy among young people in the 21st century. Across the United States and globally, young people are increasingly disillusioned with formal democratic systems, not because they are disengaged or apathetic, but because they feel systematically excluded from structures that claim to represent them. Through an interdisciplinary framework rooted in political theory, affect studies, intersectionality, and critical media analysis, this research argues that democratic trust cannot be repaired without emotional truth, structural accountability, and reimagined participation.

Drawing on the work of Lipset (1959), Crenshaw (1989), Cohen (2020), Papacharissi (2015), and Spade (2020), this …

The Impact Of Emotions On Informal Learning Experiences In The Workplace, Jennifer L. Walavalkar

University Honors Theses

This study investigates the role of emotion--specifically valence and arousal--on informal learning experiences in the workplace. As remote and flexible work environments grow, informal learning has become the dominant method through which employees acquire new skills. Drawing on theories such as Cognitive Load Theory and Ego Depletion Theory, this research explores how emotions influence cognitive processes critical to learning, such as attention, memory, and self-regulation. Prior literature suggests that both positive and negative affect (valence) impact learning outcomes, but the specific influence of emotional intensity (arousal) in informal learning remains underexplored. Using a longitudinal survey method, ten employees at Portland …

Indigenous Science And The Legacy Of Fire: Resilience, Fuels, Mosaics, And Eco-Cultural Landscapes In Oregon’S Coastal And Cascade Range, Julia Alcalá

University Honors Theses

Most of Oregon's western Cascade and Coastal range is a landscape that has historically been considered devoid of mid to low-intensity fires by Western science. However, for time immemorial, Indigenous peoples have been stewarding the forests through the use of "good fire," creating diverse and heterogenous landscapes with mixed fire regimes, ranging from less than a decade to several centuries since the last fire, resulting in a mosaic of patchy forest, oak savannas, prairies, and wetlands. Yet centuries of Indigenous displacement, cultural assimilation, and suppression of cultural burning contributed to this prevailing belief. Despite that, in recent decades, Western scientists …

Is Sharing Always Caring: Critical Discourse Analysis On The Parasociality Of Family Influencing Content On Tiktok, Riley Brown

University Honors Theses

Sharenting, the practice of parents sharing images and information about their children on social media, is a growing, cross-platform phenomenon threatening the privacy and safety of children, especially on TikTok. As this content gained popularity it became monetizable through influencer marketing, or paid partnerships with brands, and created a form of sharenting referred to as family influencing. Influencer marketing encourages the development of parasocial relationships (PSRs) to build a loyal audience for financial success. PSRs develop when a viewer forms a non-reciprocal relationship with a figure through a series of one-sided, mediated interactions simulating face-to-face or intimate interactions. The present …

Not Just An Ad: Exploring Exposure, Persuasion Knowledge, And Health Misinformation On Social Media, Danielle Murray

University Honors Theses

This study explores how exposure to sponsored health and fitness content on social media influences users' perceptions of influencer motivation and belief in health-related misinformation. Drawing on parasocial interaction (PSR), attribution theory, and influencer marketing research, this study investigates two hypotheses: that frequent exposure to branded content is positively associated with (1) perceptions of influencers as commercially motivated and (2) belief in pseudoscientific health myths. A cross-sectional online survey (N = 104) was conducted using convenience sampling of adult social media users. Results partially supported the first hypothesis: exposure frequency was positively correlated with recognition of persuasive intent, but …

Identity, Bodies, And Time: Analysis Of Transgender Education Curricula In K Through 12 Grades, Dean Weiler-Zilberman

University Honors Theses

The author analyzes lesson plans that focus on education around gender and transgender subjects--sourced from Sexual Orientation and Gender Institute (SOGI) 123 and Advocates for Youth (AFY)--and puts them in conversation with key literature on transgender education. What surfaces from their interaction are clear strong areas that support transgender education and gaps that fail transgender students.

"I Just Kind Of Wish People Knew We Existed:" Rethinking Queer Visibility, Identity, And Belonging In Rural America, Alyson C. Hagen

University Honors Theses

This thesis explores how LGBTQ+ individuals in rural America navigate identity, visibility, and belonging amid the pressures of metronormativity--the dominant cultural narrative that equates queerness with urban life. Through qualitative interviews with five queer adults who lived in rural settings, the study shows that rural queer life is shaped by not only structural erasure and limited resources but also adaptive strategies, emotional labor, and creative community-building. Participants described environments where queerness was often unspoken or denied, yet they developed contingent forms of visibility, online belonging, and grassroots kinship to survive and thrive. Although all participants had migrated to urban areas, …

Alloparenting And Male Infant Care Behaviors In Varecia Rubra (Red-Ruffed Lemur), Noelle Wilcox

University Honors Theses

Nonhuman primates are known for their complex social structures that sometimes includes cooperative breeding strategies. In recent years there has been an increase in investigating alloparenting (infant care provided by an adult or subadult that is not a genetic parent) and male infant care, and how such behaviors contribute to the overall assistance to the extreme energetic investment and costs of the mother for the rearing of offspring. There is also debate to how male care has evolved in the primate clade, be it through the theory of kin selection or theory of mutualism. However, there is not enough research …

East Portland Grid: Supporting Clean Industry And Residents, Allison Kirkpatrick, Andrew Azar, Diego Joao Murphy-Mendez, Evan Howington, Kate Carroll, Maura Paxton

Master of Urban and Regional Planning Workshop Projects

Supporting clean industry and residents in ways that are mutually beneficial requires a diversity of efforts. The Columbia Salmonry Group, working for the Portland Bureau of Planning and Sustainability, finds that designating the Sumner-Parkrose-Argay Terrace neighborhoods as a Green Resilient Industrial District (GRID) can, with the following recommendations, build on the work of community and city partners to sustain and grow clean industry in Portland. This area is well suited to be a GRID due to the close proximity of industry and residents, a history of over-planning and under-delivering of investment, and the engaged community. Focusing on the needs of …

Bridgeless To Better Burnside: Reclaiming Burnside, Reconnecting The West Side, Michael Azierski, Brian Bill, Eric Gasper, Alex Gill, Jackson Morrison, Michel Rojas

Master of Urban and Regional Planning Workshop Projects

This report, produced for Better Block PDX, is a resource for shaping the future of lower West Burnside Street during and after the 2028–2033 Burnside Bridge closure. It captures current conditions, community input, principles of transportation planning and placemaking, and recommended interventions to build a shared vision for transforming the corridor from a barrier into a pedestrian-friendly, vibrant street. Framed around a two-phase timeline, temporary interventions during the bridge closure and permanent improvements after the new bridge opens, it offers a snapshot of community visions and a blueprint for turning those visions into action. Recommended interventions for the new bridge …

Building Adaptive Capacity Through Community Visioning, Silas Carr, Isaiah Jackman, Brandon Huezo, Lara Opeifa

Master of Urban and Regional Planning Workshop Projects

East Portland represents one of Oregon’s most diverse communities. This rich cultural tapestry reflects the strength and resilience of communities who have built vibrant neighborhoods despite facing systemic exclusion and displacement. This project focuses on community engagement efforts undertaken in collaboration with the Rosewood Initiative, a community-based organization operating in East Portland. However, the legacy of discriminatory policies and practices has created concentrated challenges in East Portland, which have relegated many residents to areas with inadequate infrastructure, limited access to services, and heightened exposure to environmental hazards. Climate change intensifies these challenges, with East Portland experiencing more severe urban heat …

Joint Analysis Of The Npod-Virus Group Data: The Association Of Enterovirus With Type 1 Diabetes Is Supported By Multiple Markers Of Infection In Pancreas Tissue, Sarah J Richardson, Teresa Rodriguez-Calvo, Jutta E Laiho, John S Kaddis, Julius O Nyalwidhe, Irina Kusmartseva, Sofia Morfopoulou, Joseph F Petrosino, Vincent Plagnol, Kathrin Maedler, Margaret A Morris, Jerry L Nadler, Mark A Atkinson, Matthias Von Herrath, Richard E Lloyd, Heikki Hyoty, Noel G Morgan, Alberto Pugliese, Npod-Virus Group

Center for Medical Ethics and Health Policy Staff Publications

Aims/hypothesis: Previous pathology studies have associated enterovirus infections with type 1 diabetes by examining the enterovirus capsid protein 1 (VP1) in autopsy pancreases obtained near diabetes diagnosis. The Network for Pancreatic Organ Donors with Diabetes (nPOD) has since obtained pancreases from organ donors with type 1 diabetes (with broad age and disease duration) and donors with disease-associated autoantibodies (AAbs), the latter representing preclinical disease. Two accompanying manuscripts from the nPOD-Virus Group report primary data from a coordinated analysis of multiple enterovirus indices. We aimed to comprehensively assess the association of multiple enterovirus markers with type 1 diabetes.

Methods: The nPOD-Virus …

International Society For Cell & Gene Therapy Expanded Access Working Group Position Paper: Key Considerations To Support Equitable And Ethical Expanded Access To Investigational Cell- And Gene-Based Interventions, Elena Maryamchik, Laertis Ikonomou, Beth E Roxland, Felix Grignon, Bruce L Levine, Bambi J Grilley

Center for Medical Ethics and Health Policy Staff Publications

This position paper reviews the Expanded Access pathway for cell and gene therapies, examining its critical role at the nexus of patient need, regulatory frameworks, and scientific advancement. Spearheaded by the International Society for Cell & Gene Therapy's Expanded Access Working Group, it explores how investigational therapies are accessed outside of clinical trials for patients with serious or life-threatening conditions when no approved alternatives exist. Access to cell and gene therapy products are of specific interest to patients because many times the products are bespoke, being used to treat serious and/or incurable conditions, and are potentially curative. As the field …

Promises And Pitfalls Of Preimplantation Genetic Testing For Polygenic Disorders: A Narrative Review, Jaime A Roura-Monllor, Zachary Walker, Joel M Reynolds, Greysha Rivera-Cruz, Avner Hershlag, Gheona Altarescu, Sigal Klipstein, Stacey Pereira, Gabriel Lázaro-Muñoz, Shai Carmi, Todd Lencz, Ruth Bunker Lathi

Center for Medical Ethics and Health Policy Staff Publications

Preimplantation genetic testing for polygenic disorders (PGT-P) has been commercially available since 2019. PGT-P makes use of polygenic risk scores for conditions which are multifactorial and are significantly influenced by environmental and lifestyle factors. If current predictions are accurate, then absolute risk reductions range from about 0.02% to 10.1%, meaning that between 10 and 5,000 in vitro fertilization patients would need to be tested with PGT-P to prevent one offspring from becoming affected in the future, depending on the condition and the number of embryos available. Survey and interview data reveal that patients and the public have largely favorable views …

What Language Are We Speaking?: Marketing Information Literacy On University Library Websites, Aleksandar Golijanin

Communications in Information Literacy

This study investigates how Canadian university libraries communicate information literacy (IL) to non-library faculty members on faculty-facing web pages. A content analysis was conducted of websites from institutions affiliated with the Canadian Association of Research Libraries (n = 25) to identify trends in the terminology used to describe IL. The findings reveal that the term "information literacy" appears with varying frequency across website headings, subheadings and body text, while terms like “research skills” and “critical information use” may appear in its stead. University libraries may intentionally be employing these terms to enhance faculty engagement in response to the existing …

Visual Literacy Instruction At Scale: Developing Asynchronous Learning Objects For First-Year Art And Design Students, Jacqueline Huddle, Sarah Carter

Communications in Information Literacy

While learning modules are not new to academic librarianship, student-centered, asynchronous learning modules are an innovative approach not commonly considered within the academic librarianship literature. This article discusses the development and implementation of visual literacy asynchronous learning modules created by two librarians for a cohort of first-year studio art students. In creating these modules, the goal was to offer studio art students visual literacy instruction specific to their personal interests and future careers. Specifically, this article discusses the module design process and how student-centered learning can be incorporated into modules in order to offer deep learning opportunities.