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Social and Behavioral Sciences Commons™
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Articles 1 - 5 of 5
Full-Text Articles in Social and Behavioral Sciences
Deletion Of Abca7 Increases Cerebral Amyloid-Β Accumulation In The J20 Mouse Model Of Alzheimer's Disease, Woojin S. Kim, Hongyun Li, Kalani Ruberu, Sharon Chan, David A. Elliott, Jac Kee Low, David Cheng, Tim Karl, Brett Garner
Deletion Of Abca7 Increases Cerebral Amyloid-Β Accumulation In The J20 Mouse Model Of Alzheimer's Disease, Woojin S. Kim, Hongyun Li, Kalani Ruberu, Sharon Chan, David A. Elliott, Jac Kee Low, David Cheng, Tim Karl, Brett Garner
Faculty of Science, Medicine and Health - Papers: part A
ATP-binding cassette transporter A7 (ABCA7) is expressed in the brain and has been detected in macrophages, microglia, and neurons. ABCA7 promotes efflux of lipids from cells to apolipoproteins and can also regulate phagocytosis and modulate processing of amyloid precursor protein (APP) to generate the Alzheimer's disease (AD) amyloid-β (Aβ) peptide. Genome-wide association studies have indicated that ABCA7 single nucleotide polymorphisms confer increased risk for late-onset AD; however, the role that ABCA7 plays in the brain in the AD context is unknown. In the present study, we crossed ABCA7-deficient (A7-/-) mice with J20 amyloidogenic mice to address this issue. We show …
Developing Galleria Mellonella As A Model Host For Human Pathogens, Simon M. Cook, Jason D. Mcarthur
Developing Galleria Mellonella As A Model Host For Human Pathogens, Simon M. Cook, Jason D. Mcarthur
Faculty of Science, Medicine and Health - Papers: part A
The larvae of Galleria mellonella (also known colloquially as the wax worm) is increasingly being used as an infection model to study virulence factors and pathogenesis of many prominent bacterial and fungal human pathogens. When compared with traditional mammalian model hosts, invertebrate infection models are cheaper to establish and maintain, are more amenable to high-throughput studies and are not subjected to the same ethical constraints as vertebrates. In addition to these benefits, G. mellonella larvae possess a number of other characteristics which make these organisms particularly useful for the study of human pathogens. Larvae are relatively large in size (12- …
An Overview Of The Clubhouse Model Of Psychiatric Rehabilitation, Toby Raeburn, Elizabeth Halcomb, Garry Walter, Michelle Cleary
An Overview Of The Clubhouse Model Of Psychiatric Rehabilitation, Toby Raeburn, Elizabeth Halcomb, Garry Walter, Michelle Cleary
Faculty of Science, Medicine and Health - Papers: part A
Objective: The aim of this article is to provide an overview of the clubhouse model and its capacity to assist people with severe mental illness. Method: The paper uses a sample vignette (with all identifying information removed) and survey of literature describing clubhouses over the last 15 years. Results: Strengths of the clubhouse model include its ability to provide a safe environment, supportive relationships and supported employment activities. Criticisms include its failure to provide onsite psychiatry clinics and a risk of promoting service dependence. Conclusions: Modern clubhouses continue to provide useful models of psychiatric rehabilitation which are popular worldwide. Studying …
Paleoclimate Data-Model Comparison And The Role Of Climate Forcings Over The Past 1500 Years, Steven J. Phipps, Helen V. Mcgregor, Joelle Gergis, Ailie J. E Gallant, Raphael Neukom, Samantha Stevenson, Duncan Ackerley, Josephine R. Brown, Matt J. Fischer, Tas D. Van Ommen
Paleoclimate Data-Model Comparison And The Role Of Climate Forcings Over The Past 1500 Years, Steven J. Phipps, Helen V. Mcgregor, Joelle Gergis, Ailie J. E Gallant, Raphael Neukom, Samantha Stevenson, Duncan Ackerley, Josephine R. Brown, Matt J. Fischer, Tas D. Van Ommen
Faculty of Science, Medicine and Health - Papers: part A
The past 1500 years provide a valuable opportunity to study the response of the climate system to external forcings. However, the integration of paleoclimate proxies with climate modeling is critical to improving the understanding of climate dynamics. In this paper, a climate system model and proxy records are therefore used to study the role of natural and anthropogenic forcings in driving the global climate. The inverse and forward approaches to paleoclimate data–model comparison are applied, and sources of uncertainty are identified and discussed. In the first of two case studies, the climate model simulations are compared with multiproxy temperature reconstructions. …
Hox Measurements In The Summertime Upper Troposphere Over Europe: A Comparison Of Observations To A Box Model And A 3-D Model, E Regelin, H Harder, M Martinez, D Kubistin, C Tatum Ernest, H Bozem, T Klippel, Z Hosaynali-Beygi, H Fischer, R Sander, P Jockel, R Konigstedt, J Lelieveld
Hox Measurements In The Summertime Upper Troposphere Over Europe: A Comparison Of Observations To A Box Model And A 3-D Model, E Regelin, H Harder, M Martinez, D Kubistin, C Tatum Ernest, H Bozem, T Klippel, Z Hosaynali-Beygi, H Fischer, R Sander, P Jockel, R Konigstedt, J Lelieveld
Faculty of Science, Medicine and Health - Papers: part A
In situ airborne measurements of OH and HO2 with the HORUS (HydrOxyl Radical measurement Unit based on fluorescence Spectroscopy) instrument were performed in the summertime upper troposphere across Europe during the HOOVER 2 (HOx OVer EuRope) campaign in July 2007. Complementary measurements of trace gas species and photolysis frequencies were conducted to obtain a broad data set, which has been used to quantify the significant HOx sources and sinks. In this study we compare the in situ measurement of OH and HO2 with simulated mixing ratios from the constrained box model CAABA/MECCA (Chemistry As A Box Model Application/Module Efficiently Calculating …