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Articles 421 - 438 of 438
Full-Text Articles in Social and Behavioral Sciences
Using A Framework To Implement Large-Scale Innovation In Medical Education With The Intent Of Achieving Sustainability, Judith N. Hudson, Elizabeth Farmer, Kathryn M. Weston, John A. Bushnell
Using A Framework To Implement Large-Scale Innovation In Medical Education With The Intent Of Achieving Sustainability, Judith N. Hudson, Elizabeth Farmer, Kathryn M. Weston, John A. Bushnell
Faculty of Science, Medicine and Health - Papers: part A
Background Particularly when undertaken on a large scale, implementing innovation in higher education poses many challenges. Sustaining the innovation requires early adoption of a coherent implementation strategy. Using an example from clinical education, this article describes a process used to implement a large-scale innovation with the intent of achieving sustainability. Desire to improve the effectiveness of undergraduate medical education has led to growing support for a longitudinal integrated clerkship (LIC) model. This involves a move away from the traditional clerkship of 'block rotations' with frequent changes in disciplines, to a focus upon clerkships with longer duration and opportunity for students …
Not Just A "Challenging Behaviour", Kate Swaffer
Not Just A "Challenging Behaviour", Kate Swaffer
Faculty of Science, Medicine and Health - Papers: part A
Abstract presented at the 30th International Conference of Alzheimer's Disease International, 15 - 18 April 2015, Perth, Australia
Starvation In The Land Of Plenty: Why Australians Are Malnourished, Karen E. Charlton, Karen L. Walton
Starvation In The Land Of Plenty: Why Australians Are Malnourished, Karen E. Charlton, Karen L. Walton
Faculty of Science, Medicine and Health - Papers: part A
Malnutrition is a significant issue around the world, especially in developing countries. But it's not just a problem for poor nations; a large number of older Australians also suffer from this insidious condition, which has some very serious repercussions.
Bacterial Sliding Clamp Inhibitors That Mimic The Sequential Binding Mechanism Of Endogenous Linear Motifs, Zhou Yin, Louise R. Whittell, Yao Wang, Slobodan Jergic, Cong Ma, Peter Lewis, Nicholas E. Dixon, Jennifer L. Beck, Michael J. Kelso, Aaron J. Oakley
Bacterial Sliding Clamp Inhibitors That Mimic The Sequential Binding Mechanism Of Endogenous Linear Motifs, Zhou Yin, Louise R. Whittell, Yao Wang, Slobodan Jergic, Cong Ma, Peter Lewis, Nicholas E. Dixon, Jennifer L. Beck, Michael J. Kelso, Aaron J. Oakley
Faculty of Science, Medicine and Health - Papers: part A
The bacterial DNA replication machinery presents new targets for the development of antibiotics acting via novel mechanisms. One such target is the protein-protein interaction between the DNA sliding clamp and the conserved peptide linear motifs in DNA polymerases. We previously established that binding of linear motifs to the Escherichia coli sliding clamp occurs via a sequential mechanism that involves two subsites (I and II). Here, we report the development of small-molecule inhibitors that mimic this mechanism. The compounds contain tetrahydrocarbazole moieties as "anchors" to occupy subsite I. Functional groups appended at the tetrahydrocarbazole nitrogen bind to a channel gated by …
Evaluating The Removal Of Non-Detrital Matter From Soils And Sediment Using Uranium Isotopes, Ashley Martin, Anthony Dosseto, Leslie Kinsley
Evaluating The Removal Of Non-Detrital Matter From Soils And Sediment Using Uranium Isotopes, Ashley Martin, Anthony Dosseto, Leslie Kinsley
Faculty of Science, Medicine and Health - Papers: part A
The time elapsed since detrital minerals were reduced to < 63 μm by weathering can be constrained by applying the comminution dating method, which is based on the (234U/238U) activity ratio and surface area properties of the detrital minerals. In order to constrain an accurate age, the detrital minerals should be isolated and non-detrital matter present must be completely removed. Here we evaluate current sample pre-treatment procedures for removing non-detrital matter using uranium isotopes. The (234U/238U) activity ratio of the solid residue decreased stepwise throughout sequential extraction procedures, which is attributed to the removal of non-detrital matter. Despite the heterogeneity observed in the untreated samples, the final (234U/238U) activity ratio of solid residues from replicate experiments were within analytical error. This shows that the (234U/238U) activity ratio of the detrital minerals is consistent following removal of non-detrital matter. The addition of a complexing agent (sodium citrate) to extraction reagents decreased the readsorption of uranium, but did not affect the final (234U/238U) activity ratio. Mild HF/HCl etching experiments showed that the (234U/238U) activity ratio can be further decreased following sequential extraction. Particle-size distribution measurements revealed that the decrease in the (234U/238U) activity ratio is likely due to the dissolution of clay minerals. Mild HF/HCl etching of a rock standard also revealed a small amount of preferential leaching of 234U (< 1%). The inferred comminution ages are generally beyond the limit of the technique (1000 ka). By assuming an initial activity ratio of 0.95 to account for preferential leaching effects, the ages of samples following sequential extraction were within analytical error. Mild HF/HCl etching following sequential extraction results in older ages, which is attributed to the further removal of clay minerals. We recommend sequential extraction followed by mild HF/HCl etching as sample pre-treatment for comminution dating studies.
An Overview Of The Influential Developments And Stakeholders Within The Food Composition Program Of Australia, Yasmine Probst, Judy Cunningham
An Overview Of The Influential Developments And Stakeholders Within The Food Composition Program Of Australia, Yasmine Probst, Judy Cunningham
Faculty of Science, Medicine and Health - Papers: part A
Development of the Australian food composition program, focussing on the enablers and barriers to progress, is reviewed following a process of reference harvesting and unstructured interviews with experts. Strong growth in new data and publications during the 1930s and 1970/80s was followed by more stagnant periods, particularly during the 1990s, enabled by data needs for national nutrition surveys, labelling requirements and national policy needs. From the late 1980s there was a move from paper to computerised tables and then to online databases in the 2000s. Australia's food composition tables have evolved in line with international developments in science and changed …
Quantifying Soil Loss With In-Situ Cosmogenic 10be And 14c Depth-Profiles, Reka H. Fulop, Paul Bishop, Derek Fabel, Gordon T. Cook, Jeremy Everest, Christoph Schnabel, Alexandru T. Codilean, Sheng Xu
Quantifying Soil Loss With In-Situ Cosmogenic 10be And 14c Depth-Profiles, Reka H. Fulop, Paul Bishop, Derek Fabel, Gordon T. Cook, Jeremy Everest, Christoph Schnabel, Alexandru T. Codilean, Sheng Xu
Faculty of Science, Medicine and Health - Papers: part A
Conventional methods for the determination of past soil erosion provide only average rates of erosion of the sediment's source areas and are unable to determine the rate of at-a-site soil loss. In this study, we report in-situ produced cosmogenic 10Be, and 14C measurements from erratic boulders and two depth-profiles from Younger Dryas moraines in Scotland, and assess the extent to which these data allow the quantification of the amount and timing of site-specific Holocene soil erosion at these sites. The study focuses on two sites located on end moraines of the Loch Lomond Readvance (LLR): Wester Cameron and Inchie Farm, …
A Review Of The Nutrient Composition Of Selected Rubus Berries, Yasmine Probst
A Review Of The Nutrient Composition Of Selected Rubus Berries, Yasmine Probst
Faculty of Science, Medicine and Health - Papers: part A
Purpose - The purpose of this paper is a nutritional review of the scientific literature of four Rubus varieties: raspberry, blackberry, boysenberry and loganberry. The study aimed to review the scientific literature related to Rubus and the bioactives and key nutrients. Design/methodology/approach - Nutrient data were obtained from Australia and New Zealand, where Australian data were absent; to provide an overview of the existing and available nutrient composition data, a review of the scientific literature using defined search terms in the Web of Science and Scopus databases for the years 2001-2011 was conducted. The primary components of Rubus are the …
Effects Of 10-Year Management Regimes On The Soil Seed Bank In Saline-Alkaline Grassland, Hongyuan Ma, Haoyu Yang, Zhengwei Liang, Mark K. J Ooi
Effects Of 10-Year Management Regimes On The Soil Seed Bank In Saline-Alkaline Grassland, Hongyuan Ma, Haoyu Yang, Zhengwei Liang, Mark K. J Ooi
Faculty of Science, Medicine and Health - Papers: part A
Background Management regimes for vegetation restoration of degraded grasslands can significantly affect the process of ecological succession. However, few studies have focused on variation in the soil seed bank during vegetation restoration under different management regimes, especially in saline-alkaline grassland habitats. Our aim was to provide insights into the ecological effects of grassland management regimes on soil seed bank composition and vegetation establishment in mown, fenced, transplanted and natural grassland sites, all dominated by the perennial rhizomatous grass Leymus chinensis. Methodology We studied species composition and diversity in both the soil seed bank and aboveground vegetation in differently managed grasslands …
Rapid Response Of Silicate Weathering Rates To Climate Change In The Himalaya, Anthony Dosseto, Nathalie Vigier, Renaud C. Joannes-Boyau, Ian Moffat, T Singh, Pradeep Srivastava
Rapid Response Of Silicate Weathering Rates To Climate Change In The Himalaya, Anthony Dosseto, Nathalie Vigier, Renaud C. Joannes-Boyau, Ian Moffat, T Singh, Pradeep Srivastava
Faculty of Science, Medicine and Health - Papers: part A
Chemical weathering of continental rocks plays a central role in regulating the carbon cycle and the Earth's climate (Walker et al., 1981; Berner et al., 1983), accounting for nearly half the consumption of atmospheric carbon dioxide globally (Beaulieu et al., 2012). However, the role of climate variability on chemical weathering is still strongly debated. Here we focus on the Himalayan range and use the lithium isotopic composition of clays in fluvial terraces to show a tight coupling between climate change and chemical weathering over the past 40 ka. Between 25 and 10 ka ago, weathering rates decrease despite temperature increase …
Progressing Institutional Quality Assurance And Accreditation Of Higher Education Programmes, Dominique R. Parrish
Progressing Institutional Quality Assurance And Accreditation Of Higher Education Programmes, Dominique R. Parrish
Faculty of Science, Medicine and Health - Papers: part A
Abstract of an oral presentation.
The Online Presence Of Teaching And Learning Within Australian University Websites, Fabienne Else, Patrick A. Crookes
The Online Presence Of Teaching And Learning Within Australian University Websites, Fabienne Else, Patrick A. Crookes
Faculty of Science, Medicine and Health - Papers: part A
Teaching and Learning as a form of scholarship has struggled for recognition in universities, with one of the biggest hurdles being visibility. As the Internet is now one of the primary sources of visibility, this study examines how Australia's 39 universities present their teaching and learning profiles online. The purpose was to examine the aspects of teaching and learning that were visible and those which were not, highlighting the areas of scholarship that may require enhanced focus. The study used a scoring system of 15 primary criteria drawn from the literature, in conjunction with common teaching and learning website elements …
Strand Separation Establishes A Sustained Lock At The Tus-Ter Replication Fork Barrier, Bojk A. Berghuis, David Dulin, Zhi-Qiang Xu, Theo Van Laar, Bronwen Cross, Richard Janissen, Slobodan Jergic, Nicholas E. Dixon, Martin Depken, Nynke H. Dekker
Strand Separation Establishes A Sustained Lock At The Tus-Ter Replication Fork Barrier, Bojk A. Berghuis, David Dulin, Zhi-Qiang Xu, Theo Van Laar, Bronwen Cross, Richard Janissen, Slobodan Jergic, Nicholas E. Dixon, Martin Depken, Nynke H. Dekker
Faculty of Science, Medicine and Health - Papers: part A
The bidirectional replication of a circular chromosome by many bacteria necessitates proper termination to avoid the head-on collision of the opposing replisomes. In Escherichia coli, replisome progression beyond the termination site is prevented by Tus proteins bound to asymmetric Ter sites. Structural evidence indicates that strand separation on the blocking (nonpermissive) side of Tus-Ter triggers roadblock formation, but biochemical evidence also suggests roles for protein-protein interactions. Here DNA unzipping experiments demonstrate that nonpermissively oriented Tus-Ter forms a tight lock in the absence of replicative proteins, whereas permissively oriented Tus-Ter allows nearly unhindered strand separation. Quantifying the lock strength reveals the …
Is "Cooling Then Freezing" A Humane Way To Kill Amphibians And Reptiles?, Richard Shine, Joshua Amiel, Adam J. Munn, Mathew Stewart, Alexei L. Vyssotski, John A. Lesku
Is "Cooling Then Freezing" A Humane Way To Kill Amphibians And Reptiles?, Richard Shine, Joshua Amiel, Adam J. Munn, Mathew Stewart, Alexei L. Vyssotski, John A. Lesku
Faculty of Science, Medicine and Health - Papers: part A
What is the most humane way to kill amphibians and small reptiles that are used in research? Historically, such animals were often killed by cooling followed by freezing, but this method was outlawed by ethics committees because of concerns that ice-crystals may form in peripheral tissues while the animal is still conscious, putatively causing intense pain. This argument relies on assumptions about the capacity of such animals to feel pain, the thermal thresholds for tissue freezing, the temperature-dependence of nerve-impulse transmission and brain activity, and the magnitude of thermal differentials within the bodies of rapidly-cooling animals. A review of published …
Stabilisation Of Laryngeal Al Amyloidosis With Long Term Curcumin Therapy, Terry Golombick, Terrence H. Diamond, Arumugam Manoharan, Raj Ramakrishna
Stabilisation Of Laryngeal Al Amyloidosis With Long Term Curcumin Therapy, Terry Golombick, Terrence H. Diamond, Arumugam Manoharan, Raj Ramakrishna
Faculty of Science, Medicine and Health - Papers: part A
Multiple myeloma (MM), smoldering myeloma (SMM), and monoclonal gammopathy of undetermined significance (MGUS) represent a spectrum of plasma cell dyscrasias (PCDs). Immunoglobulin light chain amyloidosis (AL) falls within the spectrum of these diseases and has a mortality rate of more than 80% within 2 years of diagnosis. Curcumin, derived from turmeric, has been shown to have a clinical benefit in some patients with PCDs. In addition to a clinical benefit in these patients, curcumin has been found to have a strong affinity for fibrillar amyloid proteins. We thus administered curcumin to a patient with laryngeal amyloidosis and smoldering myeloma and …
Influence Of Subduction History On South American Topography, Nicolas Flament, Michael Gurnis, R Dietmar Muller, Dan J. Bower, Laurent Husson
Influence Of Subduction History On South American Topography, Nicolas Flament, Michael Gurnis, R Dietmar Muller, Dan J. Bower, Laurent Husson
Faculty of Science, Medicine and Health - Papers: part A
The Cenozoic evolution of South American topography is marked by episodes of large-scale uplift and subsidence not readily explained by lithospheric deformation. The drying up of the inland Pebas system, the drainage reversal of the Amazon river, the uplift of the Sierras Pampeanas and the uplift of Patagonia have all been linked to the evolution of mantle flow since the Miocene in separate studies. Here we investigate the evolution of long-wavelength South American topography as a function of subduction history in a time-dependent global geodynamic model. This model is shown to be consistent with these inferred changes, as well as …
Assimilating Lithosphere And Slab History In 4-D Earth Models, Dan J. Bower, Michael Gurnis, Nicolas Flament
Assimilating Lithosphere And Slab History In 4-D Earth Models, Dan J. Bower, Michael Gurnis, Nicolas Flament
Faculty of Science, Medicine and Health - Papers: part A
We develop methods to incorporate paleogeographical constraints into numerical models of mantle convection. Through the solution of the convection equations, the models honor geophysical and geological data near the surface while predicting mantle flow and structure at depth and associated surface deformation. The methods consist of four constraints determined a priori from a plate history model: (1) plate velocities, (2) thermal structure of the lithosphere, (3) thermal structure of slabs in the upper mantle, and (4) velocity of slabs in the upper mantle. These constraints are implemented as temporally- and spatially-dependent conditions that are blended with the solution of the …
Evaluation Of Assessment In The Context Of Work-Based Learning: Qualitative Perspectives Of New Graduates, Claire Palermo, Alexandra Chung, Eleanor Beck, Susan Ash, Sandra Capra, Helen Truby, Brian Jolly
Evaluation Of Assessment In The Context Of Work-Based Learning: Qualitative Perspectives Of New Graduates, Claire Palermo, Alexandra Chung, Eleanor Beck, Susan Ash, Sandra Capra, Helen Truby, Brian Jolly
Faculty of Science, Medicine and Health - Papers: part A
Aim Evaluation or assessment of competence is an important step to ensure the safety and efficacy of health professionals, including dietitians. Most competency-based assessment studies are focused on valid and reliable methods of assessment for the preparation of entry-level dietitians, few papers have explored student dietitians' perceptions of these evaluations. The present study aimed to explore the perceptions of recent graduates from accredited nutrition and dietetics training programs in Australia. It also aimed to establish the relevance of competency-based assessment to adequately prepare them for entry-level work roles. Methods A purposive sample of newly graduated dietitians with a range of …