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Social and Behavioral Sciences Commons™
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Full-Text Articles in Social and Behavioral Sciences
Toxoplasma Gondii Moderates The Association Between Multiple Folate-Cycle Factors And Cognitive Function In U.S. Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges
Toxoplasma Gondii Moderates The Association Between Multiple Folate-Cycle Factors And Cognitive Function In U.S. Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges
Faculty Publications
Toxoplasma gondii (T. gondii) is a microscopic, apicomplexan parasite that can infect muscle or neural tissue, including the brain, in humans. While T. gondii infection has been associated with changes in mood, behavior, and cognition, the mechanism remains unclear. Recent evidence suggests that T. gondii may harvest folate from host neural cells. Reduced folate availability is associated with an increased risk of neurodevelopmental disorders, neurodegenerative diseases, and cognitive decline. We hypothesized that impairment in cognitive functioning in subjects seropositive for T. gondii might be associated with a reduction of folate availability in neural cells. We analyzed data from the third …
Progressive Deterioration Of Thalamic Nuclei Relates To Cortical Network Decline In Schizophrenia, Derin J. Cobia, Matthew J. Smith, Ilse Salinas, Charlene Ng, Mohktar Gado, John G. Csernansky, Lei Wang
Progressive Deterioration Of Thalamic Nuclei Relates To Cortical Network Decline In Schizophrenia, Derin J. Cobia, Matthew J. Smith, Ilse Salinas, Charlene Ng, Mohktar Gado, John G. Csernansky, Lei Wang
Faculty Publications
Thalamic abnormalities are considered part of the complex pathophysiology of schizophrenia, particularly the involvement of specific thalamic nuclei. The goals of this study were to: introduce a novel atlas-based parcellation scheme for defining various thalamic nuclei; compare their integrity in a schizophrenia sample against healthy individuals at baseline and follow-up time points, as well as rates of change over time; examine relationships between the nuclei and abnormalities in known connected cortical regions; and finally, to determine if schizophreniarelated thalamic nuclei changes relate to cognitive functioning and clinical symptoms. Subjects were from a larger longitudinal 2-year follow-up study, schizophrenia (n=20) and …