Open Access. Powered by Scholars. Published by Universities.®
Social and Behavioral Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 5 of 5
Full-Text Articles in Social and Behavioral Sciences
Chronic Hippocampal Abnormalities And Blunted Hpa Axis In An Animal Model Of Repeated Unpredictable Stress, Moustafa Algamal, Joseph O. Ojo, Carlyn P. Lungmus, Phillip Muza, Constance Cammarata, Margaret J. Owens, Benoit C. Mouzon, David M. Diamond, Michael Mullan, Fiona Crawford
Chronic Hippocampal Abnormalities And Blunted Hpa Axis In An Animal Model Of Repeated Unpredictable Stress, Moustafa Algamal, Joseph O. Ojo, Carlyn P. Lungmus, Phillip Muza, Constance Cammarata, Margaret J. Owens, Benoit C. Mouzon, David M. Diamond, Michael Mullan, Fiona Crawford
Psychology Faculty Publications
Incidence of post-traumatic stress disorder (PTSD) ranges from 3 to 30% in individuals exposed to traumatic events, with the highest prevalence in groups exposed to combat, torture, or rape. To date, only a few FDA approved drugs are available to treat PTSD, which only offer symptomatic relief and variable efficacy. There is, therefore, an urgent need to explore new concepts regarding the biological responses causing PTSD. Animal models are an appropriate platform for conducting such studies. Herein, we examined the chronic behavioral and neurobiological effects of repeated unpredictable stress (RUS) in a mouse model. 12 weeks-old C57BL/6J male mice were …
Effects Of Vortioxetine On Biomarkers Associated With Glutamatergic Activity In An Ssri Insensitive Model Of Depression In Female Rats, N. Hlavacova, Y. Li, Alan Pehrson, Connie Sanchez, Isabel Bermudez-Diaz, Agnesa Csanova, Daniela Jezova, Michael Franklin
Effects Of Vortioxetine On Biomarkers Associated With Glutamatergic Activity In An Ssri Insensitive Model Of Depression In Female Rats, N. Hlavacova, Y. Li, Alan Pehrson, Connie Sanchez, Isabel Bermudez-Diaz, Agnesa Csanova, Daniela Jezova, Michael Franklin
Department of Psychology Faculty Scholarship and Creative Works
The aim of this study was to investigate the antidepressant activity of vortioxetine in a tryptophan (TRP) depletion female rat model of depression and compare it to that of paroxetine using doses that fully occupy the serotonin transporter (SERT). We evaluated the effects of vortioxetine on potential biomarkers associated with TRP depletion including serum aldosterone, corticosterone and IL-6 levels together with indirect indicators of glutamate neurotransmission. Female Sprague-Dawley rats were randomized to control, low TRP, low TRP/paroxetine or low TRP/vortioxetine groups. Vortioxetine and paroxetine were administered via diet (10 mg/kg/day) and drinking water (10 mg/kg/day) respectively for 14 days. Vortioxetine …
Modified Single Prolonged Stress Reduces Cocaine Self-Administration During Acquisition Regardless Of Rearing Environment, Rebecca S. Hofford, Mark A. Prendergast, Michael T. Bardo
Modified Single Prolonged Stress Reduces Cocaine Self-Administration During Acquisition Regardless Of Rearing Environment, Rebecca S. Hofford, Mark A. Prendergast, Michael T. Bardo
Psychology Faculty Publications
Until recently, there were few rodent models available to study the interaction of post-traumatic stress disorder (PTSD) and drug taking. Like PTSD, single prolonged stress (SPS) produces hypothalamic-pituitary-adrenal (HPA) axis dysfunction and alters psychostimulant self-administration. Other stressors, such as isolation stress, also alter psychostimulant self-administration. However, it is currently unknown if isolation housing combined with SPS can alter the acquisition or maintenance of cocaine self-administration. The current study applied modified SPS (modSPS; two hours restraint immediately followed by cold swim stress) to rats raised in an isolation condition (Iso), enrichment condition (Enr), or standard condition (Std) to measure changes in …
Adolescent Bisphenol-A Exposure Decreases Dendritic Spine Density: Role Of Sex And Age, Rachel E. Bowman, Victoria N. Luine, Hameda Khandaker, Joseph J. Villafane, Maya Frankfurt
Adolescent Bisphenol-A Exposure Decreases Dendritic Spine Density: Role Of Sex And Age, Rachel E. Bowman, Victoria N. Luine, Hameda Khandaker, Joseph J. Villafane, Maya Frankfurt
Psychology Faculty Publications
Bisphenol-A (BPA), a common environmental endocrine disruptor, modulates estrogenic, androgenic, and anti-androgenic effects throughout the lifespan. We recently showed that low dose BPA exposure during adolescence increases anxiety and impairs spatial memory independent of sex. In the current study, six week old Sprague Dawley rats (n=24 males, n=24 females) received daily subcutaneous injections (40 µg/kg bodyweight) of BPA or vehicle for one week. Serum corticosterone levels in response to a 1 h restraint stress and spine density were examined at age 7 (cohort 1) and 11 (cohort 2) weeks. Adolescent BPA exposure did not alter stress dependent corticosterone responses but …
Stress Alters The Discriminative Stimulus And Response Rate Effects Of Cocaine Differentially In Lewis And Fischer Inbred Rats, Therese A. Kosten, Mindy Miserendino
Stress Alters The Discriminative Stimulus And Response Rate Effects Of Cocaine Differentially In Lewis And Fischer Inbred Rats, Therese A. Kosten, Mindy Miserendino
Psychology Faculty Publications
Stress enhances the behavioral effects of cocaine, perhaps via hypothalamic-pituitary-adrenal (HPA) axis activity. Yet, compared to Fischer 344 (F344) rats, Lewis rats have hyporesponsive HPA axis function and more readily acquire cocaine self-administration. We hypothesized that stress would differentially affect cocaine behaviors in these strains. The effects of three stressors on the discriminative stimulus and response rate effects of cocaine were investigated. Rats of both strains were trained to discriminate cocaine (10 mg/kg) from saline using a two-lever, food-reinforced (FR10) procedure. Immediately prior to cumulative dose (1, 3, 10 mg/kg cocaine) test sessions, rats were restrained for 15-min, had 15-min …