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Full-Text Articles in Social and Behavioral Sciences
Effects Of Development On Hpa Function Following Pubertal Stress, Brittany D. Elliott
Effects Of Development On Hpa Function Following Pubertal Stress, Brittany D. Elliott
Graduate Theses, Dissertations, and Problem Reports
For women, two of the greatest risk factors for affective disorders are adversity experienced during puberty and later becoming pregnant. We have created a translationally relevant mouse model where we address these complex risk factors. Previously, we discovered that pregnant mice (dams) that experienced chronic variable stress (CVS) during puberty display a blunted hypothalamic-pituitary-adrenal (HPA) response when exposed to an acute stressor. Interestingly, this alteration only first becomes apparent during pregnancy, which is a sensitive period for these effects due to normative neuroendocrine changes. Further investigation of the mechanisms underlying this dysfunction revealed altered gene expression in the paraventricular nucleus …
Impact Of Adolescent Social Isolation On Adult, Binge-Like Ethanol Consumption And Plasma Corticosterone In High-Alcohol-Preferring Mice, Eva Cullins
The Journal of Purdue Undergraduate Research
Adolescent stress exposure increases the likelihood of alcohol misuse and alcohol use disorder (AUD) in adulthood; however, it is not clear how genetic and environmental factors interact to increase risk. This study examined how adolescent social isolation affects adult binge-like ethanol drinking and levels of the stress hormone corticosterone in male and female mice with a genetic predisposition toward high alcohol preference (HAP). Twenty-eight HAP mice were separated into group-housed (GH) and socially isolated (SI) conditions (n = 13, 13). Binge drinking was assessed using a drinking in the dark (DID) procedure. Blood samples were taken before DID and after …
Blocking The Acquisition Of Ethanol-Induced Conditioned Place Preference With 11, 21-Bisphenyl-19-Norpregnane (Pt150) In Coturnix Quail, Mia Radevski
Theses and Dissertations--Psychology
Alcohol use disorder (AUD) has been associated with a dysregulated stress system. Therefore, regulating stress hormones has been investigated as a potential therapeutic target for AUDs. The purpose of the current study was to investigate whether a stress hormone receptor antagonist, PT150, would block the rewarding properties of ethanol. Quail were used as subjects because a conditioned place preference (CPP) apparatus that utilized visual cues was used, and quail readily attend to visual cues. Visual cues in the environment have been shown to become associated with alcohol effects and later induce craving. Starting on day one, quail were pretreated with …
Methamphetamine-Induced Modulation Of Anxiety/Depressive-Like Behaviors And Hpa Axis Output : Contributing Factors Within Stress Associated Brain Regions, Jason Jacobskind
Methamphetamine-Induced Modulation Of Anxiety/Depressive-Like Behaviors And Hpa Axis Output : Contributing Factors Within Stress Associated Brain Regions, Jason Jacobskind
Legacy Theses & Dissertations (2009 - 2024)
Methamphetamine (MA) is a psychostimulant drug of addiction that induces a wide range ofeffects. Among its many side effects is the potentiation of cellular, physiological, and behavioral changes in the stress response system. Upon exposure, the hypothalamic-pituitary-adrenal (HPA) axis is initiated. This process entails many factors. Receiving input from other brain regions, the paraventricular nucleus (PVN) of the hypothalamus secretes corticotropin-releasing factor (CRF) and arginine vasopressin into the anterior pituitary gland. These together stimulate the synthesis and release of adrenocorticotropic hormone, which circulates via the blood stream to cause the release of glucocortoicoids, the stress hormone (CORT). Binding of glucocorticoids …
Chronic Hippocampal Abnormalities And Blunted Hpa Axis In An Animal Model Of Repeated Unpredictable Stress, Moustafa Algamal, Joseph O. Ojo, Carlyn P. Lungmus, Phillip Muza, Constance Cammarata, Margaret J. Owens, Benoit C. Mouzon, David M. Diamond, Michael Mullan, Fiona Crawford
Chronic Hippocampal Abnormalities And Blunted Hpa Axis In An Animal Model Of Repeated Unpredictable Stress, Moustafa Algamal, Joseph O. Ojo, Carlyn P. Lungmus, Phillip Muza, Constance Cammarata, Margaret J. Owens, Benoit C. Mouzon, David M. Diamond, Michael Mullan, Fiona Crawford
Psychology Faculty Publications
Incidence of post-traumatic stress disorder (PTSD) ranges from 3 to 30% in individuals exposed to traumatic events, with the highest prevalence in groups exposed to combat, torture, or rape. To date, only a few FDA approved drugs are available to treat PTSD, which only offer symptomatic relief and variable efficacy. There is, therefore, an urgent need to explore new concepts regarding the biological responses causing PTSD. Animal models are an appropriate platform for conducting such studies. Herein, we examined the chronic behavioral and neurobiological effects of repeated unpredictable stress (RUS) in a mouse model. 12 weeks-old C57BL/6J male mice were …
Effects Of Vortioxetine On Biomarkers Associated With Glutamatergic Activity In An Ssri Insensitive Model Of Depression In Female Rats, N. Hlavacova, Y. Li, Alan Pehrson, Connie Sanchez, Isabel Bermudez-Diaz, Agnesa Csanova, Daniela Jezova, Michael Franklin
Effects Of Vortioxetine On Biomarkers Associated With Glutamatergic Activity In An Ssri Insensitive Model Of Depression In Female Rats, N. Hlavacova, Y. Li, Alan Pehrson, Connie Sanchez, Isabel Bermudez-Diaz, Agnesa Csanova, Daniela Jezova, Michael Franklin
Department of Psychology Faculty Scholarship and Creative Works
The aim of this study was to investigate the antidepressant activity of vortioxetine in a tryptophan (TRP) depletion female rat model of depression and compare it to that of paroxetine using doses that fully occupy the serotonin transporter (SERT). We evaluated the effects of vortioxetine on potential biomarkers associated with TRP depletion including serum aldosterone, corticosterone and IL-6 levels together with indirect indicators of glutamate neurotransmission. Female Sprague-Dawley rats were randomized to control, low TRP, low TRP/paroxetine or low TRP/vortioxetine groups. Vortioxetine and paroxetine were administered via diet (10 mg/kg/day) and drinking water (10 mg/kg/day) respectively for 14 days. Vortioxetine …
Modified Single Prolonged Stress Reduces Cocaine Self-Administration During Acquisition Regardless Of Rearing Environment, Rebecca S. Hofford, Mark A. Prendergast, Michael T. Bardo
Modified Single Prolonged Stress Reduces Cocaine Self-Administration During Acquisition Regardless Of Rearing Environment, Rebecca S. Hofford, Mark A. Prendergast, Michael T. Bardo
Psychology Faculty Publications
Until recently, there were few rodent models available to study the interaction of post-traumatic stress disorder (PTSD) and drug taking. Like PTSD, single prolonged stress (SPS) produces hypothalamic-pituitary-adrenal (HPA) axis dysfunction and alters psychostimulant self-administration. Other stressors, such as isolation stress, also alter psychostimulant self-administration. However, it is currently unknown if isolation housing combined with SPS can alter the acquisition or maintenance of cocaine self-administration. The current study applied modified SPS (modSPS; two hours restraint immediately followed by cold swim stress) to rats raised in an isolation condition (Iso), enrichment condition (Enr), or standard condition (Std) to measure changes in …
The Impact Of Neonatal Pain And Reduced Maternal Care On Brain And Behavioral Development, Sean Michael Mooney-Leber
The Impact Of Neonatal Pain And Reduced Maternal Care On Brain And Behavioral Development, Sean Michael Mooney-Leber
Wayne State University Dissertations
In the neonatal intensive care unit (NICU) preterm infants are exposed to a multitude of stressors, which include both neonatal pain and reduced maternal care. Clinical and preclinical research has demonstrated that exposure to neonatal pain and reduced maternal care has a profound negative impact on brain and behavioral development. Currently, the biological mechanism by which both of these stressors impacts brain and behavioral outcomes remains widely unknown. To uncover a potential biological mechanism, the current dissertation project utilized a preclinical model of repetitive needle pokes and developed a novel model of reduced maternal care through tea-ball encapsulation. Briefly, rat …
Characterizing The Role Of Glucocorticoids In The Sign Tracking Behavior Of Male Japanese Quail (Coturnix Japonica), Beth A. Rice
Characterizing The Role Of Glucocorticoids In The Sign Tracking Behavior Of Male Japanese Quail (Coturnix Japonica), Beth A. Rice
Theses and Dissertations--Psychology
A devastating feature of drug-dependence is the susceptibility of relapse (40-60%) after stretches of abstinence. One theory that may account for relapse suggests that drug cues (e.g., paraphernalia) may increase stress hormones, and this may prompt relapse. Repeatedly pairing a neutral cue with a reward is commonly utilized to measure what subjects learn about a cue that is predictive of reward. Research has shown that animals that attend to a cue more than to the reward (sign trackers) may be more vulnerable to drug addiction. Additionally, research has shown that sign tracking is associated with an increase in corticosterone (CORT), …
An Animal Model Of Flashbulb Memory: Insights Into The Time-Dependent Mechanisms Of Memory Enhancement, Laura Ashley Bullard
An Animal Model Of Flashbulb Memory: Insights Into The Time-Dependent Mechanisms Of Memory Enhancement, Laura Ashley Bullard
USF Tampa Graduate Theses and Dissertations
The vivid memory of an emotional event, as well as memory for incidental details associated with the arousing event, has been referred to collectively as a “flashbulb memory”. An important aspect of flashbulb memory in people is that an emotional event enhances memory of contextual details, such as the weather, or clothes one was wearing at the time of the event. Therefore, an emotional event not only produces a detailed memory of the event, itself, but also enhances memory for contextual details that would otherwise not be remembered. The first goal of this work is to describe the development of …
Effectiveness Of Different Corticosterone Administration Methods To Alter Corticosterone Levels In Serum And Depressive-Like Behavior In Female Rats, Jennifer Marie Kott
Effectiveness Of Different Corticosterone Administration Methods To Alter Corticosterone Levels In Serum And Depressive-Like Behavior In Female Rats, Jennifer Marie Kott
Wayne State University Theses
There is wide variation in the current literature on rodent models of high levels of chronic stress. This study aims to reduce these discrepancies by investigating the effects of 3 different administration methods of corticosterone (CORT; the endogenous stress hormone in rodents) and the differential effects it has in the female sex. The majority of studies utilize male rodents, while research in female rodents is largely under-investigated. This study will utilize female rats and 3 different administration routes: a) subcutaneous implantation of a CORT pellet, b) CORT in the drinking water, and c) CORT by a daily subcutaneous injection, and …
Adolescent Bisphenol-A Exposure Decreases Dendritic Spine Density: Role Of Sex And Age, Rachel E. Bowman, Victoria N. Luine, Hameda Khandaker, Joseph J. Villafane, Maya Frankfurt
Adolescent Bisphenol-A Exposure Decreases Dendritic Spine Density: Role Of Sex And Age, Rachel E. Bowman, Victoria N. Luine, Hameda Khandaker, Joseph J. Villafane, Maya Frankfurt
Psychology Faculty Publications
Bisphenol-A (BPA), a common environmental endocrine disruptor, modulates estrogenic, androgenic, and anti-androgenic effects throughout the lifespan. We recently showed that low dose BPA exposure during adolescence increases anxiety and impairs spatial memory independent of sex. In the current study, six week old Sprague Dawley rats (n=24 males, n=24 females) received daily subcutaneous injections (40 µg/kg bodyweight) of BPA or vehicle for one week. Serum corticosterone levels in response to a 1 h restraint stress and spine density were examined at age 7 (cohort 1) and 11 (cohort 2) weeks. Adolescent BPA exposure did not alter stress dependent corticosterone responses but …
Stress And Social Relationships: The Role Of Corticosterone In The Formation And Maintenance Of Pair Bonds In The Monogamous Zebra Finch (Taeniopygia Guttata), Kimberly Anne Laplante
Stress And Social Relationships: The Role Of Corticosterone In The Formation And Maintenance Of Pair Bonds In The Monogamous Zebra Finch (Taeniopygia Guttata), Kimberly Anne Laplante
Wayne State University Dissertations
Stress and affiliative social relationships are bi-directionally related. It is well understood that social relationships can buffer the physiological response to a stressor. Conversely, there is some evidence to suggest that stress can affect the propensity to form a pair bond. Data from humans and prairie voles, monogamous rodents, suggest that activation of the hypothalamic-pituitary-adrenal axis (HPA) in males increases attraction for females. Across species, females are understudied, but evidence from the prairie vole suggests HPA activation impairs formation of partner preference, the first step in establishing a pair bond. Across taxa there is evidence that formation and maintenance of …
Characterizing Consumption, Dependence, And The Role Of Glucocorticoids In An Animal Model Of Voluntary Ethanol Consumption, Lynda Sharrett-Field
Characterizing Consumption, Dependence, And The Role Of Glucocorticoids In An Animal Model Of Voluntary Ethanol Consumption, Lynda Sharrett-Field
Theses and Dissertations--Psychology
Alcohol abuse disorders (AUD) represent a serious worldwide health problem with far reaching social, financial, and interpersonal implications. One of the most devastating facets of these disorders is the propensity to relapse following periods of abstinence. Ethanol withdrawal (EWD) is believed to promote relapse by increasing anxiety and craving, and may contribute to the development of cognitive decline associated with long-term dependence. Clinical data suggest that stress also plays a main role in both the development of AUD as well as relapse to drinking. As a physiological stressor, EtOH elevates levels of stress hormones (cortisol in humans, corticosterone (CORT) in …
Stress Alters The Discriminative Stimulus And Response Rate Effects Of Cocaine Differentially In Lewis And Fischer Inbred Rats, Therese A. Kosten, Mindy Miserendino
Stress Alters The Discriminative Stimulus And Response Rate Effects Of Cocaine Differentially In Lewis And Fischer Inbred Rats, Therese A. Kosten, Mindy Miserendino
Psychology Faculty Publications
Stress enhances the behavioral effects of cocaine, perhaps via hypothalamic-pituitary-adrenal (HPA) axis activity. Yet, compared to Fischer 344 (F344) rats, Lewis rats have hyporesponsive HPA axis function and more readily acquire cocaine self-administration. We hypothesized that stress would differentially affect cocaine behaviors in these strains. The effects of three stressors on the discriminative stimulus and response rate effects of cocaine were investigated. Rats of both strains were trained to discriminate cocaine (10 mg/kg) from saline using a two-lever, food-reinforced (FR10) procedure. Immediately prior to cumulative dose (1, 3, 10 mg/kg cocaine) test sessions, rats were restrained for 15-min, had 15-min …
Stress-Induced Alterations In Hippocampal Plasticity, Place Cells, And Spatial Memory, Jeansok J. Kim, Hongjoo J. Lee, Adam C. Welday, Eunyoung Song, Jeiwon Cho, Patricia E. Sharp, Min W. Jung, Hugh T. Blair
Stress-Induced Alterations In Hippocampal Plasticity, Place Cells, And Spatial Memory, Jeansok J. Kim, Hongjoo J. Lee, Adam C. Welday, Eunyoung Song, Jeiwon Cho, Patricia E. Sharp, Min W. Jung, Hugh T. Blair
Patricia E Sharp
Acute, inescapable, and unpredictable stress can profoundly modify brain and cognition in humans and animals. The present study investigated the ensuing effects of 2-h variable "audiogenic" stress on three related levels of hippocampal functions in rats: long-term potentiation, place cell activity, and spatial memory. In agreement with prior findings, we observed that stress reduced the magnitude of Schaffer collateral/commissural-Cornu Ammonis field 1 long-term potentiation in vitro, and selectively impaired spatial memory on a hidden platform version of the Morris water maze task. We also observed that stress impaired the stability of firing rates (but not firing locations) of place cells …