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Full-Text Articles in Social and Behavioral Sciences
Role Of Dorsostriatal D1 And D2 Receptors In Modulating The Kappa Opioid-Mediated Locomotor Activity Of Preweanling Rats: Importance Of Synergistic Activation, Sergios Charntikov
Role Of Dorsostriatal D1 And D2 Receptors In Modulating The Kappa Opioid-Mediated Locomotor Activity Of Preweanling Rats: Importance Of Synergistic Activation, Sergios Charntikov
Theses Digitization Project
Infusions of the nonselective dopamine agonist R( - ) propylnorapomorphine (NPA) into the dorsal striatum of preweanling rats atteuates kappa opioid-mediated locomotor activity. The purpose of this thesis was to ascertain which dopamine receptor subtype (D1 or D2) is responsible for this effect. It was hypothsized that a) D1, but not D2, receptors in the dorsal striatum underlie NPA's ability to attenuate the kappa opioid-mediated locomotor activity of preweanling rats, and b) microinjectng SKF38393 (a D1 agonist), and not quinpirole (a D2 agonist), would attenuate kappa opioid-mediated locomotion.