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Articles 1 - 11 of 11
Full-Text Articles in Social and Behavioral Sciences
Adolescent And Adult Nicotine Exposure On The Acquisition Of Methamphetamine Self-Administration And The Reinstatement Of Extinguished Methamphetamine-Seeking In Male Rats, Joseph Allan Pipkin
Adolescent And Adult Nicotine Exposure On The Acquisition Of Methamphetamine Self-Administration And The Reinstatement Of Extinguished Methamphetamine-Seeking In Male Rats, Joseph Allan Pipkin
Theses Digitization Project
This study sought to determine the individual and combined contribution of adolescent and adult nicotine exposure on METH self-administration and METH-seeking behavior in male rats. Nicotine is a commonly abused substance among adolescents and is believed to be a "gateway" to other drugs of abuse. In support of the gateway hypothesis, cigarette smoking during adolescence is related to increased methamphetamine (METH) use in adulthood.
Role Of The Ventral Tegmental Area And Nucleus Accumbens For The One-Trial Behavioral Sensitization Of The Preweanling Rat, Alexandria Grace Pothier
Role Of The Ventral Tegmental Area And Nucleus Accumbens For The One-Trial Behavioral Sensitization Of The Preweanling Rat, Alexandria Grace Pothier
Theses Digitization Project
Behavioral sensitization is defined as an increase in behavioral responding that occurs after repeated administration of a psychostimulant. Behavioral sensitization is an important component of the addiction process that is mediated by different brain regions. In this thesis, lidocaine was used to determine those brain areas mediating one-trial behavioral sensitization in preweanling rats.
Paradoxical Behavior Effects Of Dopamine Receptor Inactivation In Preweanling Rats: Role Of The Dorsal Striatum, Taleen Siran Der-Ghazarian
Paradoxical Behavior Effects Of Dopamine Receptor Inactivation In Preweanling Rats: Role Of The Dorsal Striatum, Taleen Siran Der-Ghazarian
Theses Digitization Project
The purpose of this thesis was to: a) investigate the effects of intrastriatally administered N-ethoxycarbonyl-2ethoxy-1, 2-dihydroquinoline (EEDQ) on nonselective dopamine agonists (NPA) -induced locomotor activity in preweanling and adult rats; b) determine which dopamine receptor subtype (D1- or D2-like) is responsible for modulating EEDQ's paradoxical behavioral effects in preweanling rats; and c) examine the magnitude of EEDQ-induced D1- and D2-like receptor inactivation in both adult and preweanling rats. Subjects were 252 male and female rat pups of Sprague-Dawley descent (Charles River Laboratories, Hollister, CA, USA), born and raised at California State University, San Bernardino (CSUSB).
Ontogeny Of One-Trial Behavioral Sensitization In Preweanling, Adolescent, And Adult Rats: Differential Effects Of Cocaine And Methamphetamine, Olga Olia Kozanian
Ontogeny Of One-Trial Behavioral Sensitization In Preweanling, Adolescent, And Adult Rats: Differential Effects Of Cocaine And Methamphetamine, Olga Olia Kozanian
Theses Digitization Project
The purpose of this thesis was to assess the ontogeny of cocaine- and methamphetamine-induced one-trial locomotor sensitization in preweanling, adolescent, and adult rats. Subjects were 336 male and female rats of Sprague-Dawley descent that were raised at California State University, San Bernardino (CSUSB).
Consequences Of Early Methylphenidate Exposure On Opioid System Functioning In Adult Rats, Matthew Scott Herbert
Consequences Of Early Methylphenidate Exposure On Opioid System Functioning In Adult Rats, Matthew Scott Herbert
Theses Digitization Project
Methylphenidate is the preferred treatment for attention-deficit hyperactivity disorder in preschool-aged children, even though few human studies have assessed the long-term consequences of early methyphenidate use. In rats, exposure to methylphenidate during a developmental period that approximates early childhood increases morphine-induced antinociception in adulthood. However, because morphine activates three distinct opioid receptors it is unknown which receptor is resonsible for this methylphenidate effect. The purpose of the present study was to assess the long-term effects of early methylphenidate exposure on DAMGO- and U50, 488-induced antinociception, a mu-opioid and kappa-opioid selective agonist.
Role Of Dorsostriatal D1 And D2 Receptors In Modulating The Kappa Opioid-Mediated Locomotor Activity Of Preweanling Rats: Importance Of Synergistic Activation, Sergios Charntikov
Role Of Dorsostriatal D1 And D2 Receptors In Modulating The Kappa Opioid-Mediated Locomotor Activity Of Preweanling Rats: Importance Of Synergistic Activation, Sergios Charntikov
Theses Digitization Project
Infusions of the nonselective dopamine agonist R( - ) propylnorapomorphine (NPA) into the dorsal striatum of preweanling rats atteuates kappa opioid-mediated locomotor activity. The purpose of this thesis was to ascertain which dopamine receptor subtype (D1 or D2) is responsible for this effect. It was hypothsized that a) D1, but not D2, receptors in the dorsal striatum underlie NPA's ability to attenuate the kappa opioid-mediated locomotor activity of preweanling rats, and b) microinjectng SKF38393 (a D1 agonist), and not quinpirole (a D2 agonist), would attenuate kappa opioid-mediated locomotion.
The Effects Of (Rs)-Mcpg On Amphetamine-Induced Sensitization In Neonatal Rats, Fiona Yeuk-Lun Choi
The Effects Of (Rs)-Mcpg On Amphetamine-Induced Sensitization In Neonatal Rats, Fiona Yeuk-Lun Choi
Theses Digitization Project
The purpose of the study was to investigate the role of metabotropic glutamate receptors (mGluR) in the ontogeny of amphetamine-induced behavioral sensitization. Eleven-day-old rat pups were given five daily bilateral infusions of the mGluR antagonist, (RS)-methyl-4-carboxyphenylglycine (MCPG) followed by a systemic injection of amphetamine and locomotor activity was measured. It was hypothesized that rats receving amphetamine pretreatment and an amphetamine challenge would exhibit a significant increase in activity, indicating short-term behavioral sensitization. As predicted, repeated amphetamine administration during the pretreatment phase produced progressively enhanced locomotor activity, indicating the development of behavioral sensitization. The effect of MCPG on locomotor activity appears …
Biconditional Discrimination Learning In Rats With 192 Igg-Saporin Lesions Of The Nucleus Basalis Magnocellularis, Michael Ryan Kitto
Biconditional Discrimination Learning In Rats With 192 Igg-Saporin Lesions Of The Nucleus Basalis Magnocellularis, Michael Ryan Kitto
Theses Digitization Project
The experiment tested the hypothesis that 192 IgG-saporin lesions of the nucleus basalis magnocellularis (NBM) in rats would impair performance in a biconditional visual discrimination task, which requires configural association learning. Experiment used 22 male Long-Evan rats (Harlan Sprague-Dawley). Behavioral testing was conducted in two identical T-mazes. Rats were randomly assigned to either a bilateral 192 IgG-saporin lesion group (n = 10) or to a control group (n = 12). Results support the hypothesis that NBM is critically involved in configural but not simple association learning and suggest that NBM may be involved more generally in cognitive flexibility.
Actions Of A Partial D2-Like Agonist During Low Or High Dopaminergic Tone: A Neurochemical Study Using Preweanling Rats, Shelly Taeko Yoshida
Actions Of A Partial D2-Like Agonist During Low Or High Dopaminergic Tone: A Neurochemical Study Using Preweanling Rats, Shelly Taeko Yoshida
Theses Digitization Project
The neurochemical effects of partial D2-like agonists (i.e., terguride) to alter striatal DOPA accumulation under high and low dopaminergic tone was examined in preweanling rats. The results indicate that terguride has agonist-like (quinpirole-like) effects under a low dopaminergic tone and antagonist-like (haloperidol-like) effects under a high dopaminergic tone during the preweanling period.
Effect Of Preweanling Methylphenidate Exposure On The Induction, Extinction And Reinstatement Of Morphine-Induced Conditioned Place Preference In Rats, Kellie Lynn Kucher
Effect Of Preweanling Methylphenidate Exposure On The Induction, Extinction And Reinstatement Of Morphine-Induced Conditioned Place Preference In Rats, Kellie Lynn Kucher
Theses Digitization Project
This study examined the effect of preweanling methyphenidate exposure on later drug reward. We examined the induction, extinction, and reinstatement of morphine induced conditioned place preference (CPP) in rats that received methylphenidate pretreatment during the preweanling period.
The Effects Of The Kappa Opioid Agonist U-50,488 On Locomotor Activity Of The Preweanling Rat Following Bilateral Microinjection Into The Substantia Nigra Pars Reticulata And Striatum, Robert Linwood Collins
The Effects Of The Kappa Opioid Agonist U-50,488 On Locomotor Activity Of The Preweanling Rat Following Bilateral Microinjection Into The Substantia Nigra Pars Reticulata And Striatum, Robert Linwood Collins
Theses Digitization Project
No abstract provided.