Social and Behavioral Sciences Commons^™

Dissociating Allopregnanolone Mnemonic Effects From Sedation, Sarah B. Hartman

Honors Projects

Allopregnanolone (Allop) is a neurosteroid metabolite of progesterone. Allop modulates cognition, specifically learning and memory, but these effects are frequently confounded by its anxiolytic and sedative properties. We attempted to dissociate the anxiolytic effects of Allop from its mnemonic effects by employing a pharmacological challenge with d- amphetamine. Because previous research suggests that the effects of Allop may vary with the cognitive domain being tested, we assessed both spatial and non-spatial memory. Spatial memory was tested in a Morris Water Maze, and non-spatial object memory was tested on a novel discrimination task. Allop, alone or in combination with d-amphetamine …