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Full-Text Articles in Social and Behavioral Sciences
Dissociating Allopregnanolone Mnemonic Effects From Sedation, Sarah B. Hartman
Dissociating Allopregnanolone Mnemonic Effects From Sedation, Sarah B. Hartman
Honors Projects
Allopregnanolone (Allop) is a neurosteroid metabolite of progesterone. Allop modulates cognition, specifically learning and memory, but these effects are frequently confounded by its anxiolytic and sedative properties. We attempted to dissociate the anxiolytic effects of Allop from its mnemonic effects by employing a pharmacological challenge with d- amphetamine. Because previous research suggests that the effects of Allop may vary with the cognitive domain being tested, we assessed both spatial and non-spatial memory. Spatial memory was tested in a Morris Water Maze, and non-spatial object memory was tested on a novel discrimination task. Allop, alone or in combination with d-amphetamine …