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Social and Behavioral Sciences Commons™
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Articles 1 - 2 of 2
Full-Text Articles in Social and Behavioral Sciences
A Multi-Site Resting State Fmri Study On The Amplitude Of Low Frequency Fluctuations In Schizophrenia, Jessica Turner, Eswar Damaraju, Theo G. M. Van Erp, Daniel H. Mathalon, Judith Ford, James Voyvodic, Bryon A. Mueller, Aysenil Belger, Juan Bustillo, Sarah Mcewin, Steven G. Potkin, Vince D. Calhoun
A Multi-Site Resting State Fmri Study On The Amplitude Of Low Frequency Fluctuations In Schizophrenia, Jessica Turner, Eswar Damaraju, Theo G. M. Van Erp, Daniel H. Mathalon, Judith Ford, James Voyvodic, Bryon A. Mueller, Aysenil Belger, Juan Bustillo, Sarah Mcewin, Steven G. Potkin, Vince D. Calhoun
Psychology Faculty Publications
Background: This multi-site study compares resting state fMRI amplitude of low frequency fluctuations (ALFF) and fractional ALFF (fALFF) between patients with schizophrenia (SZ) and healthy controls (HC). Methods: Eyes-closed resting fMRI scans (5:38 min; n = 306, 146 SZ) were collected from 6 Siemens 3T scanners and one GE 3T scanner. Imaging data were pre-processed using an SPM pipeline. Power in the low frequency band (0.01–0.08 Hz) was calculated both for the original pre-processed data as well as for the pre-processed data after regressing out the six rigid-body motion parameters, mean white matter (WM) and cerebral spinal fluid (CSF) signals. …
Potential Impact Of Mir-137 And Its Targets In Schizophrenia, Carrie Wright, Jessica Turner, Vince D. Calhoun, Nora I. Perrone-Bizzozero
Potential Impact Of Mir-137 And Its Targets In Schizophrenia, Carrie Wright, Jessica Turner, Vince D. Calhoun, Nora I. Perrone-Bizzozero
Psychology Faculty Publications
The significant impact of microRNAs (miRNAs) on disease pathology is becoming increas- ingly evident. These small non-coding RNAs have the ability to post-transcriptionally silence the expression of thousands of genes. Therefore, dysregulation of even a single miRNA could confer a large polygenic effect. Schizophrenia is a genetically complex illness thought to involve multiple genes each contributing a small risk. Large genome-wide association studies identified miR-137, a miRNA shown to be involved in neuronal maturation, as one of the top risk genes. To assess the potential mechanism of impact of miR-137 in this disorder and identify its targets, we used a …