Social and Behavioral Sciences Commons^™

Microglial P38Α Mapk Is Critical For Lps-Induced Neuron Degeneration, Through A Mechanism Involving Tnfα, Bin Xing, Adam D. Bachstetter, Linda J. Van Eldik

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: The p38α MAPK isoform is a well-established therapeutic target in peripheral inflammatory diseases, but the importance of this kinase in pathological microglial activation and detrimental inflammation in CNS disorders is less well understood. To test the role of the p38α MAPK isoform in microglia-dependent neuron damage, we used primary microglia from wild-type (WT) or p38α MAPK conditional knockout (KO) mice in co-culture with WT cortical neurons, and measured neuron damage after LPS insult.

RESULTS: We found that neurons in co-culture with p38α-deficient microglia were protected against LPS-induced synaptic loss, neurite degeneration, and neuronal death. The involvement of the proinflammatory …

Alternative Medical Care And Livelihood In Latin America = 拉丁美洲另類醫療與人民生計實踐, Aleida Guevara

South South Forum 南南論壇

No abstract provided.

Reclaiming Fat, Emilie Debaie

Health Sciences Student Scholarship

No abstract provided.

Driving Qi With Research: Findings From Public Health Pbrns, Glen P. Mays

Health Management and Policy Presentations

Public health agencies are increasingly experimenting with quality improvement (QI) strategies designed to enhance the effectiveness and efficiency of their efforts. Does QI work in public health, and if so for whom and under what circumstances? What QI strategies work best for which types of public health process failures, and at what cost? Research underway through the Public Health Practice-Based Research Networks (PBRN) Program is examining these types of questions to build an evidence base for public health QI.

Chhs December 2011 E-Newsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, Wku College Of Health And Human Services, Western Kentucky University

College of Health & Human Services Publications

No abstract provided.

Gestation Length, Mode Of Delivery And Neonatal Line Thickness Variation, CléMent Zanolli, Luca Bondioli, Franz Manni, Paola Rossi, Roberto Macchiarelli

Human Biology Open Access Pre-Prints

The transition from an intra- to extra-uterine environment leaves its mark in deciduous teeth (and first permanent molars) as an accentuated enamel incremental ring called the neonatal line (NL). This prominent microfeature separates the enamel formed during intrauterine life from that formed after leaving the womb. However, while the physical structure of this scar is well known, the bases of its formation are still a matter of investigation. In particular, besides the influence of the birth-related abrupt environmental and dietary changes and the role played by physiological factors such as hypocalcaemia, it has been suggested a direct relationship between NL …

A Non-Invasive Assay For Monitoring Stress Responses: A Comparison Between Wild And Captive-Reared Rainbowfish (Melanoteania Duboulayi), Amina Zuberi, Sinan Ali, Culum Brown

Aquaculture Collection

The stress response of wild and captive reared rainbowfish (Melanoteania duboulayi) following chasing by a simulated predator was examined. Cortisol release rate was monitored using a flow through system by measuring water borne hormone levels. Tests using known cortisol concentrations revealed that the technique yielded 95% of the cortisol present in the water. Cortisol release rates increased several fold in both populations after being chased but peaked at different time periods. Wild fish showed a typical stress response with release rate rising to (2.29±0.22 ng g⁻¹ h⁻¹) 2 h after exposure followed by rapid recovery. The captive-reared …

Lessons From Chimpanzee-Based Research On Human Disease: The Implications Of Genetic Differences, Jarrod Bailey

Laboratory Experiments Collection

Assertions that the use of chimpanzees to investigate human diseases is valid scientifically are frequently based on a reported 98–99% genetic similarity between the species. Critical analyses of the relevance of chimpanzee studies to human biology, however, indicate that this genetic similarity does not result in sufficient physiological similarity for the chimpanzee to constitute a good model for research, and furthermore, that chimpanzee data do not translate well to progress in clinical practice for humans. Leading examples include the minimal citations of chimpanzee research that is relevant to human medicine, the highly different pathology of HIV/AIDS and hepatitis C virus …

Measuring Accessibility To Primary Care Physicians In The Nashville Metropolitan Statistical Area, Sami M. Almudaris

Masters Theses & Specialist Projects

The growing concern for the shortage of primary care physicians (PCPs) prompted a government legislation to designate areas where shortage in the delivery of primary care services occurs. The implemented systems (e.g., HPSA, MUA, and MUP) analyze utilization of health services within confined administrative units and fail to account for spatial interactions that occur across administrative borders. This research examines the spatial accessibility to PCPs and the underlying demographic and socioeconomic settings. With the Nashville Metropolitan Statistical Area (MSA) as a study area, this study utilized data from the U.S. Census 2000 and 2010, as well as the known locations …

Specific Contributions Of Ventromedial, Anterior Cingulate, And Lateral Prefrontal Cortex For Attentional Selection And Stimulus Valuation., Daniel Kaping, Martin Vinck, R Matthew Hutchison, Stefan Everling, Thilo Womelsdorf

Brain and Mind Institute Researchers' Publications

Attentional control ensures that neuronal processes prioritize the most relevant stimulus in a given environment. Controlling which stimulus is attended thus originates from neurons encoding the relevance of stimuli, i.e. their expected value, in hand with neurons encoding contextual information about stimulus locations, features, and rules that guide the conditional allocation of attention. Here, we examined how these distinct processes are encoded and integrated in macaque prefrontal cortex (PFC) by mapping their functional topographies at the time of attentional stimulus selection. We find confined clusters of neurons in ventromedial PFC (vmPFC) that predominantly convey stimulus valuation information during attention shifts. …

Wind Turbines And Health, Richard Philp

Data and Test Instruments

In an effort to reduce the polluting effects of coal-fired electrical generators the Province of Ontario passed the Green Energy Act in 2009. Included in the act were clauses that removed authority from regional governments to control the placement of wind turbine or solar panel 'farms'. In concequence, forests of wind turbines sprang up throughout rural Ontario, angering rural residents and the tourist industry. Despite government claims that low frequency noise (LFN) posed no risks to health, hundreds of complaints quickly surfaced from people experiencing sleep disruption, headache, dizziness, and a host of other neurobehavioural adverse effects. This article reviews …

Full Issue, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Graduate Scholar Profiles, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Teachers’ And Parents’ Perspective As How The Social Environment Of Immediate Vicinity Can Affect The Academic Learning Of A Child 4-6 Years Age Group, Salma Amin Rattani, Deedar Shah

School of Nursing & Midwifery

In the process of human development environment plays a pivotal role. At the age of 4 -6 years, children's immediate vicinity expands from home to school and in his social environment parents and teachers play a vital role. Therefore, in this study which was conducted in Phander district Ghizer, Northern areas; of Pakistan, employing descriptive research design five parents and five school teachers were enrolled. Participants shared their definition and understanding about social environment and immediate vicinity and its effects on academic learning. This research is part of Advanced Diploma in Human Development: Early Child Development Programme, Aga Khan University. …

Message From The Senior Vice Provost And Dean Of Undergraduate Studies, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Notes From The Director, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Friends Of The Library Mcnair Scholarship Awards, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Mentor Profile, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Acknowledgements, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Mcnair Scholars Program, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Empathy-Based Conservation: An Interdisciplinary Approach To Conservation Policy And Decision-Making, Kaitlyn Delashmutt

Department of Environmental Studies: Undergraduate Student Theses

In the late 20^th century, neuroscientists in Italy discovered a neuron in the brain capable of mentally mimicking the emotions derived from the actions of others (Rizzolatti and Craighero, 2004). It is the process that makes your elbow ache when someone else knocks their elbow on the counter or the uncontrollable smile that creeps up when someone smiles at you. No questions asked, people intuitively sense what others are feeling. The old school of thought was that humans deduced through logic and reason the actions of others and interpreted the emotions through a rational process (Carew et al, 2008). …

The Effect Of Gender Role And Males' Attitudes Toward Receiving Mental Health Therapy, Christina H. Thomas

Graduate Theses

The purpose of this research study was to build upon previous research pertaining to gender role and young adult male attitudes towards receiving mental health therapy. An additional purpose of the study was to explore the relationship between media exposure and attitude toward mental health therapy. The first hypothesis was that there would be a positive correlation between gender role scores and attitudes with the BEM Sex- Role Inventory (BSRI) and with scores on attitudes with the Attitudes Towards Seeking Professional Psychological Help Scale (ATSPPHS) in young adult males. The second hypothesis was that young adult males who watched a …

Effect Of Environmental Conditions On Perceived Psychological Restorativeness Of Coastal Parks, J. Aaron Hipp, Oladele A. Ogunseitan

Brown School Faculty Publications

We investigated the hypothesis that perception of psychological restorativeness during visits to coastal parks is modified by objective and perceived environmental conditions. Visitors (n=1,153) to California beaches completed a survey on perceived weather, environmental quality, and perceived restorativeness. We used generalized ordinal logistic models to estimate the association between environmental parameters and odds of perceiving higher levels of restorativeness. Visitors perceived greater restorativeness at beaches when ambient temperatures were at or below mean monthly temperatures and during low tides. The odds of perceiving the environment as more psychologically restorative were three times greater when visiting on days defined by government …

Examining The Effect Of Medical Risk, Parental Stress, And Self-Efficacy On Parent Behaviors And The Home Environment Of Premature Children, Kathryn Woods

College of Education and Human Sciences: Dissertations, Theses, and Student Research

The purpose of this study was to examine the relationship between medical risk and parenting stress and the extent to which parental self-efficacy moderates the relationship between medical risk, parenting stress, specific parenting behaviors (i.e., parental responsivity, acceptance of child, parental involvement) and the home environment (i.e., organization of environment, learning materials, variety in experience, and IT-HOME total score) of premature children. Participants included 72 parent-child dyads with premature children between the ages of 7 and 35 months corrected age. Measures included parent reports of medical risk, stress, self-efficacy, and the IT-HOME. Results show that medical risk was not significantly …

Effect Of A Work Site Exercise Program On Selected Fitness And Psychological Parameters, Kristen Ann Christiansen

UNLV Theses, Dissertations, Professional Papers, and Capstones

The increasing rates of obesity continue to threaten the vitality of our nation. Health care costs are soaring and chronic diseases are reaching even the youngest populations. Physical activity is an integral component in reversing the obesity epidemic and improving the health of today's workforce. The present study sought to determine the effect of a work site exercise program on select fitness and psychological parameters. Five female employees participated in a six-week exercise program utilizing HealthBeat(TM) outdoor exercise equipment in a circuit fashion for 30 minutes, 2 days per week. Eighty percent of participants were categorized as sedentary or low-active …

The Influence Of Ethnic Identity And Family Support On Posttraumatic Symptoms In Maltreated Youth, Harpreet Kaur

UNLV Theses, Dissertations, Professional Papers, and Capstones

Maltreated children are at greater risk of developing PTSD than nonmaltreated children (Ackerman et al., 1998; Epstein et al., 1997; Famularo et al., 1996; Kilpatrick et al., 2003; Widom, 1999). This study sought to assess the role of ethnicity, ethnic identity, and family support on the effects of maltreatment and trauma in adolescents. Participants (n=145) included adolescents from Child Haven, a Department of Family Services (DFS)-related site in Las Vegas, and youths in foster care assessed at the offices of Dr. Stephanie Holland. The first hypothesis was that non-Caucasian youth would have higher levels of PTSD-related symptoms than Caucasian youth. …

A Comparative Study Of Indicator Bacteria Present In Ice And Soda From Las Vegas Food Establishments, Kimberly Jo Hertin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Microbial analysis has long been used as an indicator of water quality. Since the passing of the Safe Drinking Water Act in 1974, microbial standards have been strictly set by the Environmental Protection Agency (EPA) to ensure that the public health is protected from bacterial pathogens. The bacteriological quality of water generally deteriorates as it travels from water treatment facilities through the main distribution system and into private plumbing and distribution systems. For example, Heterotrophic Plate Count (HPC) values typically increase once the water has entered plumbing devices such as beverage vending machines. Upon reaching a private facility, the opportunity …

Guinea Pigging In Philadelphia, Roberto Abadie

Department of Sociology: Faculty Publications

On June 16, 2001, the national press first reported the death of Ellen Roche, a healthy 24-year-old who volunteered for an asthma study at Johns Hopkins University. The story revealed that a few days into the trial she felt very sick, was discharged, and sent home. Within some hours she checked into the emergency room at a local hospital and fell into a coma. Ellen remained in this state until her death a month later. She had received $375 for participating in seven to nine sessions as an outpatient in the clinical drug study that resulted in her death.

This …

Leaving Home Care: Decision Making, Risk Scenarios & Services Gaps In The Home Care System, Jacey J. Vaughan, Nina M. Silverstein

Gerontology Institute Publications

Home and community-based services (HCBS) enable older and disabled adults to age-in-place in their homes and communities by helping them function independently for as long as possible (Grabowski et al., 2010; Wong & Silverstein, 2011). Previous studies well document that older adults prefer receiving HCBS rather than institutional care at a nursing home (e.g., Walker, 2010; Fox-Grage, Coleman, & Freiman, 2006). Medicaid is a major source of funding for long-term care. Currently, a large proportion of Medicaid funds in most states has been spent on institutional care (National Conference of State Legislatures & AARP, 2009), and older adults and their …

A Brief Content Analysis Of Attachment And Sexual Relationships In Sex Therapy And Research Journals, Kathryn Zambrano Devis

UNLV Theses, Dissertations, Professional Papers, and Capstones

A surge of scholarly publications on attachment within couple relationships prompted this content analysis of attachment articles published in six sex therapy and sex research journals. This study investigates the extent to which these journals attend to attachment in the context of adult sexual relationships. The researcher found 2257 articles published within these journals; 64 of which attend to attachment and 9 of which attend to attachment and sex. Implications for couples therapy in the field of sex therapy and future directions are discussed.