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Full-Text Articles in Social and Behavioral Sciences

Breadtalk: Managing An Expanding Brand Portfolio, Singapore Management University Mar 2016

Breadtalk: Managing An Expanding Brand Portfolio, Singapore Management University

Perspectives@SMU

The Singapore-based company has expanded into foodcourts and restaurants in 17 countries. How can it manage its burgeoning portfolio of brands?


Non-Human Primates In Neuroscience Research: The Case Against Its Scientific Necessity, Jarrod Bailey, Katy Taylor Mar 2016

Non-Human Primates In Neuroscience Research: The Case Against Its Scientific Necessity, Jarrod Bailey, Katy Taylor

Experimentation Collection

Public opposition to non-human primate (NHP) experiments is significant, yet those who defend them cite minimal harm to NHPs and substantial human benefit. Here we review these claims of benefit, specifically in neuroscience, and show that: a) there is a default assumption of their human relevance and benefit, rather than robust evidence; b) their human relevance and essential contribution and necessity are wholly overstated; c) the contribution and capacity of non-animal investigative methods are greatly understated; and d) confounding issues, such as species differences and the effects of stress and anaesthesia, are usually overlooked. This is the case in NHP …


Does Environmental Enrichment Promote Recovery From Stress In Rainbow Trout?, Kieran C. Pounder, Jennifer L. Mitchell, Jack S. Thomson, Tom G. Pottinger, Jonathan Buckley, Lynne U. Sneddon Mar 2016

Does Environmental Enrichment Promote Recovery From Stress In Rainbow Trout?, Kieran C. Pounder, Jennifer L. Mitchell, Jack S. Thomson, Tom G. Pottinger, Jonathan Buckley, Lynne U. Sneddon

Experimental Research and Animal Welfare Collection

The EU Directive on animal experimentation suggests that all protected animals should have enrichment to improve welfare yet relatively little research has been conducted on the impact of enrichment in fish. Studies employing enrichment in zebrafish have been contradictory and all fish species should be provided with species-specific enrichments relevant to their ecology. Salmonids are important experimental models in studies within aquaculture, toxicology and natural ecosystems. This study therefore sought to establish whether an enriched environment in an experimental aquarium may promote improved welfare in rainbow trout (Oncorhynchus mykiss) by enhancing their recovery from invasive procedures. Trout were …


Circulating Amino Acids In Blood Plasma During The Peripartal Period In Dairy Cows With Different Liver Functionality Index, Z. Zhou, J. J. Loor, F. Piccioli-Cappelli, F. Librandi, G. E. Lobley, E. Trevisi Mar 2016

Circulating Amino Acids In Blood Plasma During The Peripartal Period In Dairy Cows With Different Liver Functionality Index, Z. Zhou, J. J. Loor, F. Piccioli-Cappelli, F. Librandi, G. E. Lobley, E. Trevisi

Physiology Collection

The liver functionality index (LFI) measures the changes of albumin, cholesterol, and bilirubin concentrations between 3 and 28 d postpartum. This composite index, based on variables with direct relevance to liver-specific plasma protein synthesis (albumin), hepatic/intestinal lipoprotein synthesis (cholesterol), and clearance of breakdown products of heme catabolism (bilirubin), provides a tool for evaluating manifestations of hepatic disease. Both energy and protein metabolism are likely to be affected by various physiological challenges in this period but have not been tested systematically. The present study was conducted to profile AA in cows with high or low LFI during the peripartal period …


Plant Community Composition And Structure Monitoring For Scotts Bluff National Monument, 2011-2015 Summary Report, Isabel W. Ashton, Christopher J. Davis Mar 2016

Plant Community Composition And Structure Monitoring For Scotts Bluff National Monument, 2011-2015 Summary Report, Isabel W. Ashton, Christopher J. Davis

United States National Park Service: Publications

Executive Summary

The Northern Great Plains Inventory & Monitoring Program and Fire Effects Program have been monitoring vegetation in Scotts Bluff National Monument for over 18 years. While methods have changed slightly, this report summarizes data from over 80 locations from 1998-2015. Below, we list the questions we asked using these data and provide a summarized answer. For more details see the full report. A summary of the current condition (2011-2015) and trends (based on 1988-2015) in plant communities at Scotts Bluff is found in Table ES-1.

1. What is the current status of plant community composition and structure of …


Semantic, Cognitive, And Perceptual Computing: Paradigms That Shape Human Experience, Amit P. Sheth, Pramod Anantharam, Cory Henson Mar 2016

Semantic, Cognitive, And Perceptual Computing: Paradigms That Shape Human Experience, Amit P. Sheth, Pramod Anantharam, Cory Henson

Kno.e.sis Publications

Unlike machine-centric computing, in which efficient data processing takes precedence over contextual tailoring, human-centric computation provides a personalized data interpretation that most users find highly relevant to their needs. The authors show how semantic, cognitive, and perceptual computing paradigms work together to produce actionable information.


A Model Of The Effects Of Deforestation On Local Climate In The North Cascades, Monica R. H. Jasper Mar 2016

A Model Of The Effects Of Deforestation On Local Climate In The North Cascades, Monica R. H. Jasper

Geography and the Environment: Graduate Student Capstones

Changes in areal extent of land cover types may lead to alterations in the surface energy budget that contribute to anthropogenic climate forcing. This study examines the effects of deforestation in the Cascade Range on local temperature. Temperature sensors were installed in 14 forest stands, taking measurements for one year. Estimated tree age, circumference, and species were recorded to calculate stand density index. Satellite imagery was used to calculate shade fraction from spectral mixture analysis, which is a proxy for canopy structure and density. These data were used to construct seasonal cycles of temperature to model variation with stand density …


Assessing The Impacts Of Federal Forest Planning On Wildfire Risk Mitigation In The Pacific Northwest, Usa, Alan A. Ager, Michelle A. Day, Karen C. Short, Cody R. Evers Mar 2016

Assessing The Impacts Of Federal Forest Planning On Wildfire Risk Mitigation In The Pacific Northwest, Usa, Alan A. Ager, Michelle A. Day, Karen C. Short, Cody R. Evers

Environmental Science and Management Faculty Publications and Presentations

We analyzed the impact of amenity and biodiversity protection as mandated in national forest plans on the implementation of hazardous fuel reduction treatments aimed at protecting the wildland urban interface (WUI) and restoring fire resilient forests. We used simulation modeling to delineate areas on national forests that can potentially transmit fires to adjacent WUI. We then intersected these areas with national forest planning maps to determine where mechanical treatments are allowed for restoration and fire protection, versus areas where they are prohibited. We found that a large proportion of the national forest lands (79%) can spawn fires that burn adjacent …


A Systems Approach To Animal Communication, Eileen A. Hebets, Andrew B. Barron, Christopher N. Balakrishnan, Mark E. Hauber, Paul H. Mason, Kim L. Hoke Mar 2016

A Systems Approach To Animal Communication, Eileen A. Hebets, Andrew B. Barron, Christopher N. Balakrishnan, Mark E. Hauber, Paul H. Mason, Kim L. Hoke

Eileen Hebets Publications

Why animal communication displays are so complex and how they have evolved are active foci of research with a long and rich history. Progress towards an evolutionary analysis of signal complexity, however, has been constrained by a lack of hypotheses to explain similarities and/or differences in signalling systems across taxa. To address this, we advocate incorporating a systems approach into studies of animal communication—an approach that includes comprehensive experimental designs and data collection in combination with the implementation of systems concepts and tools. A systems approach evaluates overall display architecture, including how components interact to alter function, and how function …


Mechanisms Of Methane Transport Through Populus Trichocarpa, Ellynne Marie Kutschera, M. A. K. Khalil, Andrew Rice, Todd Rosenstiel Mar 2016

Mechanisms Of Methane Transport Through Populus Trichocarpa, Ellynne Marie Kutschera, M. A. K. Khalil, Andrew Rice, Todd Rosenstiel

Physics Faculty Publications and Presentations

Although the dynamics of methane (CH4) emission from croplands and wetlands have been fairly well investigated, the contribution of trees to global CH4 emission and the mechanisms of tree transport are relatively unknown. CH4 emissions from the common wetland tree species Populus trichocarpa (black cottonwood) native to the Pacific Northwest were measured under hydroponic conditions in order to separate plant transport mechanisms from the influence of soil processes. Roots were exposed to CH4 enriched water and canopy emissions of CH4 were measured. The average flux for 34 trials (at temperatures ranging from 17 to 25 °C) was 2.8 ± 2.2 …


Early-Career Residential Migration Of Agriculture And Human Environmental Sciences B.S. Graduates: Evidence From One Land-Grant University, Donald M. Johnson, Catherine W. Shoulders, Leslie D. Edgar Feb 2016

Early-Career Residential Migration Of Agriculture And Human Environmental Sciences B.S. Graduates: Evidence From One Land-Grant University, Donald M. Johnson, Catherine W. Shoulders, Leslie D. Edgar

Journal of Human Sciences and Extension

The zip codes of agriculture (n = 346) and human environmental sciences (n = 304) bachelor’s degree graduates were examined six to seven years after graduation to describe and compare pre-college and post-college residences (rural versus metropolitan) by major and overall. A majority of agriculture graduates were from rural areas (61.6%), and a majority of human environmental sciences graduates were from metropolitan areas (55.9%). Majorities of both agriculture (54.9%) and human environmental sciences (70.1%) graduates lived in metropolitan areas post-graduation, resulting in a net loss of 100 college-educated rural youth. Among rural graduates, there was no significant difference in the …


Full Issue, Volume 4, Number 1, Donna J. Peterson Feb 2016

Full Issue, Volume 4, Number 1, Donna J. Peterson

Journal of Human Sciences and Extension

No abstract provided.


Interpreting Ambiguous Social Cues In Unpredictable Contexts, F. Caroline Davis, Maital Neta, M. Justin Kim, Joseph M. Moran, Paul J. Whalen Feb 2016

Interpreting Ambiguous Social Cues In Unpredictable Contexts, F. Caroline Davis, Maital Neta, M. Justin Kim, Joseph M. Moran, Paul J. Whalen

Dartmouth Scholarship

Unpredictable environments can be anxiety-provoking and elicit exaggerated emotional responses to aversive stimuli. Even neutral stimuli, when presented in an unpredictable fashion, prime anxiety-like behavior and elicit heightened amygdala activity. The amygdala plays a key role in initiating responses to biologically relevant information, such as facial expressions of emotion. While some expressions clearly signal negative (anger) or positive (happy) events, other expressions (e.g. surprise) are more ambiguous in that they can predict either valence, depending on the context. Here, we sought to determine whether unpredictable presentations of ambiguous facial expressions would bias participants to interpret them more negatively. We used …


Cadmium Contamination In Farmland Soil And Water Near Zinc Mining Site, Kanitta Jiraungkoorskul, Sara Arphorn, Mathuros Tipayamongholgul, Wattasit Siriwong Feb 2016

Cadmium Contamination In Farmland Soil And Water Near Zinc Mining Site, Kanitta Jiraungkoorskul, Sara Arphorn, Mathuros Tipayamongholgul, Wattasit Siriwong

Kesmas

Penelitian ini merupakan penelitian potong lintang yang dilakukan di Kecamatan Phatadpaeng, Kota Mae Sod, Provinsi Tak, Thailand. Penelitian ini bertujuan untuk mengetahui konsentrasi kadmium pada air dan tanah pertanian serta pada pemukiman petani dan rumah tangga. Konsentrasi kadmium pada 48 sampel tanah dan air pemukiman petani, 12 sampel rumah tangga, enam sampel tanah pertanian, dan delapan sampel air pertanian ditelusuri menggunakan Graphite Furnace Atomic Absorption Spectrophotometer. Uji Mann-Whitney U digunakan untuk analisis perbedaan konsentrasi kadmium antara tanah pertanian dan tanah pemukiman, air pertanian dan air pemukiman. Hasil penelitian menunjukkan tidak terdapat perbedaan secara statistik pada seluruh matriks, namun air dan …


Study On Clinical, Histopathological Features And Evaluation Results Of Skin Cancer Treatment In Can Tho Oncology Hospital, Nguyen Van Qui, Phan Nguyen Ngoc Feb 2016

Study On Clinical, Histopathological Features And Evaluation Results Of Skin Cancer Treatment In Can Tho Oncology Hospital, Nguyen Van Qui, Phan Nguyen Ngoc

Kesmas

Kanker kulit, diagnosis kanker paling umum, cenderung mengalami peningkatan. Kondisi ini secara khusus merupakan isu penting di negara-negara maju. Penelitian ini bertujuan untuk mendeskripsikan fitur klinis, fitur hispatologis, komplikasi dan hasil pengobatan bedah awal kanker kulit di Rumah Sakit Onkologi Can Tho dari tahun 2014 sampai 2015. Penelitian deskriptif prospektif ini melibatkan seluruh pasien dengan kanker kulit nonmelanoma yang diuji dan diobati di Rumah Sakit Onkologi Can Tho dari Juli 2014 sampai Maret 2015. Terdapat 78 kasus terpilih. Kanker kulit ditemukan lebih umum pada pasien yang lebih tua. Prevalensi karsinoma sel basal ditemukan lebih tinggi dibandingkan karsinoma sel skuamosa dengan …


Knowledge And Behavior Change Of People Living With Hiv Through Nutrition Education And Counseling, Fitri Hudayani, Ratu Ayu Dewi Sartika Feb 2016

Knowledge And Behavior Change Of People Living With Hiv Through Nutrition Education And Counseling, Fitri Hudayani, Ratu Ayu Dewi Sartika

Kesmas

HIV, AIDS, dan gizi saling berhubungan. Pada Unit Pelayanan Terpadu HIV Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo, layanan edukasi dan konseling gizi disediakan secara kolaboratif untuk orang yang hidup dengan HIV. Penelitian ini bertujuan untuk mengetahui pengaruh pendidikan dan konseling gizi terhadap pengetahuan dan perilaku orang yang hidup dengan HIV. Penelitian ini dilakukan dengan desain kuasi eksperimental menggunakan kelompok perlakuan dan kontrol. Kelompok perlakuan terdiri dari 25 sampel dan 29 sampel untuk kelompok kontrol, dilakukan sebelum dan setelah perlakuan. Sampel berusia dewasa antara 18 – 50 tahun dipilih dengan menerapkan kriteria inklusi dan eksklusi. Sampel uji-t berpasangan digunakan …


Communication Of Parents, Sexual Content Intake And Teenage Sexual Behavior At Senior High School In Banjarmasin City, Rusmilawaty Rusmilawaty, Yuniarti Yuniarti, Tri Tunggal Feb 2016

Communication Of Parents, Sexual Content Intake And Teenage Sexual Behavior At Senior High School In Banjarmasin City, Rusmilawaty Rusmilawaty, Yuniarti Yuniarti, Tri Tunggal

Kesmas

Perilaku seks bebas di kalangan remaja Kota Banjarmasin belakangan ini semakin mengkhawatirkan para orangtua. Kurangnya pendidikan seksologi berdampak para remaja cenderung melakukan hubungan seksual pranikah yang akan berakibat pada kehamilan yang tidak diinginkan dan pernikahan dini. Komunikasi orangtua-anak dan paparan media baik media cetak maupun elektronik merupakan cara untuk mengurangi perilaku seksual berisiko. Tujuan penelitian ini untuk mengetahui hubungan komunikasi orangtua dan asupan muatan seksual dengan perilaku seksual remaja sekolah menengah atas (SMA) di Kota Banjarmasin. Untuk mencapai tujuan tersebut, penelitian survei analitik dengan pendekatan potong lintang dilakukan pada bulan Juli – Oktober 2015 di dua sekolah negeri dan satu …


Influence Of Household Environment And Maternal Behaviors To Upper Respiratory Infection Among Toddlers, Reny Fahdiyani, Ardini S. Raksanagara, Hadyana Sukandar Feb 2016

Influence Of Household Environment And Maternal Behaviors To Upper Respiratory Infection Among Toddlers, Reny Fahdiyani, Ardini S. Raksanagara, Hadyana Sukandar

Kesmas

Infeksi saluran pernapasan akut atas (ISPA atas) di negara berkembang menyebabkan morbiditas tinggi pada anak bawah usia lima tahun (balita). Kementerian Kesehatan Republik Indonesia melaporkan bahwa ISPAnonpneumonia meningkat 2,6% dari tahun 2007 ke 2011. Faktor risiko yang dapat berkontribusi termasuk lingkungan dan perilaku. Penelitian ini bertujuan untuk menyelidiki faktor perilaku dan lingkungan dengan ISPA atas pada balita. Studi kasus kontrol ini dilakukan dari Februari-April 2015 pada balita di Tamansari yang merupakan daerah kumuh di Kota Bandung. Kasus adalah 55 ibu dengan balita menderita ISPA atas yang datang ke puskesmas, sedangkan kontrol dua kali lebih besar dari kasus dipilih dari lingkungan …


Predisposing Factors With Complementary Feeding Practices Among 9-11 Month-Old Infants In Jakarta Urban Slum Area, Septriana Septriana, Gita Ardelia Suhartono Feb 2016

Predisposing Factors With Complementary Feeding Practices Among 9-11 Month-Old Infants In Jakarta Urban Slum Area, Septriana Septriana, Gita Ardelia Suhartono

Kesmas

Penyebab utama kekurangan gizi selain dari penyakit infeksi adalah pola asuh yang tidak sesuai dan pemberian makan yang optimal menjadi salah satu cara untuk mengatasi konsekuensi jangka panjang dari kekurangan zat gizi. Penelitian ini bertujuan untuk mengetahui hubungan antara faktor pendukung praktik pemberian makanan pendamping air susu ibu (MPASI) pada bayi usia 9 - 11 bulan di daerah kumuh perkotaan Jakarta. Penelitian potong lintang ini melibatkan 50 orang pengasuh bayi usia 9 – 11 bulan. Data dikumpulkan melalui wawancara menggunakan kuesioner. Tidak terdapat hubungan yang bermakna antara usia pengasuh dengan praktik pemberian makan (nilai p = 0,645). Demikian juga dengan …


Residential Density, Parents’ Sexual Activity And Teenage Sexual Behavior In Yogyakarta, Luluk Rosida, Evi Martha, Besral Besral Feb 2016

Residential Density, Parents’ Sexual Activity And Teenage Sexual Behavior In Yogyakarta, Luluk Rosida, Evi Martha, Besral Besral

Kesmas

Pada daerah kumuh dan padat, orangtua sering terpaksa harus berbagi ruang tidur dengan anak-anaknya sehingga anak-anaknya sudah terpapar dengan aktivitas seksual sejak dini. Penelitian ini bertujuan mengetahui kepadatan hunian, aktivitas seksual orangtua, dan efeknya terhadap perilaku seksual remaja di Yogyakarta. Penelitian ini menggunakan desain potong lintang dengan mewawancarai 268 keluarga yang memiliki anak remaja yang dipilih secara acak di daerah kumuh perkotaan dan daerah pedesaan pada bulan Maret – Mei 2015. Analisis data dilakukan menggunakan uji kai kuadrat dan regresi-cox multivariat. Hasil penelitian ini menunjukkan bahwa orangtua yang tinggal di hunian padat memiliki risiko dua kali lebih besar untuk melakukan …


Effects Of Mothers’ Attitude As Breeders And Distance Of Stockyard Toward Diarrhea Incidence Among Toddlers, Yarmaliza Yarmaliza, Sugito Sugito, Teuku Reza Ferasyi, Nurliana Nurliana, Razali Razali Feb 2016

Effects Of Mothers’ Attitude As Breeders And Distance Of Stockyard Toward Diarrhea Incidence Among Toddlers, Yarmaliza Yarmaliza, Sugito Sugito, Teuku Reza Ferasyi, Nurliana Nurliana, Razali Razali

Kesmas

Diare merupakan penyakit dengan perubahan bentuk dan konsentrasi tinja yang melembek sampai mencair, dan bertambahnya frekuensi buang air besar lebih dari biasanya (tiga kali atau lebih dalam sehari). Di Provinsi Aceh, terdapat kasus diare sebanyak 48/1.000 kelahiran hidup pada 2013. Di Kabupaten Aceh Barat, pada tahun 2014 terdapat 1.071 kasus, sedangkan di Kecamatan Meureubo terdapat sebanyak 70 kasus pada anak bawah lima tahun (balita). Penelitian ini bertujuan untuk mengetahui hubungan sikap ibu sebagai peternak dan jarak kandang ternak terhadap kejadian diare pada balita di wilayah kerja Puskesmas Kecamatan Meureubo. Penelitian ini dilakukan secara potong lintang pada bulan Juli – September …


An Animal Victim's Best Chance: Veterinary Legal Duty To Report Cruelty In The U.S., Lora Dunn Feb 2016

An Animal Victim's Best Chance: Veterinary Legal Duty To Report Cruelty In The U.S., Lora Dunn

Animal Sentience

Legislation throughout the U.S. recognizes animal sentience and the importance of veterinary reporting to combat the ongoing suffering of these animal victims: All 50 states have felony penalties available for animal cruelty crimes, and veterinary reporting is permitted or required in the majority of states. The remaining minority of U.S. states should take action to require veterinarians to report animal cruelty and render veterinarians immune for good faith reporting.


Veterinary Medical Associations Need To Educate Veterinarians For Mandatory Reporting Of Suspected Animal Abuse, Melinda V. Merck Feb 2016

Veterinary Medical Associations Need To Educate Veterinarians For Mandatory Reporting Of Suspected Animal Abuse, Melinda V. Merck

Animal Sentience

When animals are suffering, we have a duty to take action. With appropriate incentive and educational support mandatory veterinary reporting can be a great legal avenue to help ensure their safety and welfare.


Fish Pain's Burden Of Proof, Carl Safina Feb 2016

Fish Pain's Burden Of Proof, Carl Safina

Animal Sentience

A hypothesis like Key’s, that fish cannot feel pain, should really be stated as a null hypothesis — an assumption that there is no difference in the things being compared. Then evidence — including anecdotal evidence — for and against rejecting the null hypothesis can be examined and weighed. Key (2016a) has proven only that fish lack mammalian brains.


Burden Of Proof Lies With Proposer Of Celestial Teapot Hypothesis, Brian Key Feb 2016

Burden Of Proof Lies With Proposer Of Celestial Teapot Hypothesis, Brian Key

Animal Sentience

Bertrand Russell famously imagined the existence of a celestial teapot to highlight that the burden of proof of a hypothesis lay with its proposer and it was not the responsibility of others to refute it. Those who propose that fish feel pain must bear the burden of proof for their hypothesis. There are several common arguments adopted by those defending the position that fish feel pain. For instance, proponents envisage that pain is so important for human survival that they can’t imagine fish could exist without it. Out of this argument from incredulity emerges the idea that pain must have …


Associations Between Domestic-Dog Morphology And Behaviour Scores In The Dog Mentality Assessment, Holly R. Stone, Paul D. Mcgreevy, Melissa J. Starling, Bjorn Forkman Feb 2016

Associations Between Domestic-Dog Morphology And Behaviour Scores In The Dog Mentality Assessment, Holly R. Stone, Paul D. Mcgreevy, Melissa J. Starling, Bjorn Forkman

Morphology Collection

The domestic dog shows a wide range of morphologies, that humans have selected for in the process of creating unique breeds. Recent studies have revealed correlations between changes in morphology and behaviour as reported by owners. For example, as height and weight decrease, many undesirable behaviours (non-social fear, hyperactivity and attention seeking) become more apparent. The current study aimed to explore more of these correlations, but this time used reports from trained observers. Phenotypic measurements were recorded from a range of common dog breeds (n = 45) and included cephalic index (CI: the ratio of skull width to skull length), …


Animal Suffering In China, Peter J. Li Feb 2016

Animal Suffering In China, Peter J. Li

Animal Sentience

Chinese policy has been aimed at maximizing GDP; it is time to focus also on minimizing animal suffering.


Science And Sensibility, Bernard E. Rollin Feb 2016

Science And Sensibility, Bernard E. Rollin

Animal Sentience

The sentience and suffering of animals is obvious to common sense, even if science and industry claim to be agnostic. Economic incentives to reduce the suffering of animals are welcome, but it is not clear whether animals can turn to science for help.


When The Client Is Not The Abuser, But One Of The Abused, Tania Signal Feb 2016

When The Client Is Not The Abuser, But One Of The Abused, Tania Signal

Animal Sentience

The question of client confidentiality and reporting animal abuse is complicated when the client is not the abuser, and when the abuse (of both people and animals) may escalate precisely because it has been (or may be) reported.


Mw151 Inhibited Il-1Β Levels After Traumatic Brain Injury With No Effect On Microglia Physiological Responses, Adam D. Bachstetter, Zhengqiu Zhou, Rachel K. Rowe, Bin Xing, Danielle S. Goulding, Alyssa N. Conley, Pradoldej Sompol, Shelby Meier, Jose F. Abisambra, Jonathan Lifshitz, D. Martin Watterson, Linda J. Van Eldik Feb 2016

Mw151 Inhibited Il-1Β Levels After Traumatic Brain Injury With No Effect On Microglia Physiological Responses, Adam D. Bachstetter, Zhengqiu Zhou, Rachel K. Rowe, Bin Xing, Danielle S. Goulding, Alyssa N. Conley, Pradoldej Sompol, Shelby Meier, Jose F. Abisambra, Jonathan Lifshitz, D. Martin Watterson, Linda J. Van Eldik

Sanders-Brown Center on Aging Faculty Publications

A prevailing neuroinflammation hypothesis is that increased production of proinflammatory cytokines contributes to progressive neuropathology, secondary to the primary damage caused by a traumatic brain injury (TBI). In support of the hypothesis, post-injury interventions that inhibit the proinflammatory cytokine surge can attenuate the progressive pathology. However, other post-injury neuroinflammatory responses are key to endogenous recovery responses. Therefore, it is critical that pharmacological attenuation of detrimental or dysregulated neuroinflammatory processes avoid pan-suppression of inflammation. MW151 is a CNS-penetrant, small molecule experimental therapeutic that restores injury- or disease-induced overproduction of proinflammatory cytokines towards homeostasis without immunosuppression. Post-injury administration of MW151 in a …