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Social and Behavioral Sciences Commons™
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Full-Text Articles in Social and Behavioral Sciences
Neural Circuitry Underlying The Intrusion Of Task-Irrelevant Threat Into Working Memory In Anxiety, Daniel Stout
Neural Circuitry Underlying The Intrusion Of Task-Irrelevant Threat Into Working Memory In Anxiety, Daniel Stout
Theses and Dissertations
Dispositional anxiety is an important risk factor for the development of anxiety and other psychological disorders. Symptoms commonly expressed by highly anxious individuals include intrusive memories, uncertainty, and worry — all occurring in the absence of immediate threat. This raises the possibility that anxious individuals have difficulty governing threat’s access to working memory, the mental workspace where goal-related information is actively retained for guiding on-going behavior. Using functional magnetic resonance imaging (fMRI) while 81 subjects completed a well-validated working memory task, I show that threat-related and neutral distracters unnecessarily gain access to working memory, as evidenced by increased neural activity …
Neural Plasticity Of Extinction: Relations With Anxiety And Extinction Retention, Emily Louise Belleau
Neural Plasticity Of Extinction: Relations With Anxiety And Extinction Retention, Emily Louise Belleau
Theses and Dissertations
ABSTRACT
NEURAL PLASTICITY OF EXTINCTION LEARNING: RELATIONS WITH ANXIETY AND EXTINCTION RETENTION
by
Emily L. Belleau
The University of Wisconsin-Milwaukee, 2016
Under the Supervision of Associate Professor Christine Larson
Anxiety is a significant public health problem characterized by substantial psychological, physical, and economic burden. A key feature of anxiety is the inability to regulate fear. Aberrant extinction of conditioned fear is one prominent model of the etiology of anxiety disorders. Previous studies have shown that the neural circuitry underlying anxiety pathology overlaps with that mediating fear extinction learning. Recently, more precise pathways supporting the expression (CMA-aMCC) and inhibition (BLA-vmPFC) of …