Social and Behavioral Sciences Commons^™

Viral Injection Of Rna Polymerase Ii-Interacting Protein Rprd2 In The Nucleus Accumbens Induces Anxiety-Like Behavior In Mice, Hannah E. Woolard

Theses and Dissertations

Anxiety and its related disorders have become increasingly prevalent as more awareness and acceptance of mental illnesses have come to fruition, especially in the light of the ongoing COVID-19 pandemic. Anxiety can affect anyone regardless of their age, sex, or social status and is currently the most commonly diagnosed mental illness worldwide (Bandelow & Michaelis, 2015). While there are several effective treatments available, the underlying brain mechanisms that cause anxiety are still largely unknown and further research continues to piece together the complex pathophysiology behind this disease. The use of laboratory animal models, such as mice, to induce and observe …

Neural Substrates Of Fear Generalization And Its Associations With Anxiety And Intolerance Of Uncertainty, Ashley Ann Huggins

Theses and Dissertations

Fear generalization - the tendency to interpret ambiguous stimuli as threatening due to perceptual similarity to a learned threat – is an adaptive process. Overgeneralization, however, is maladaptive and has been implicated in a number of anxiety disorders. Neuroimaging research has indicated several regions sensitive to effects of generalization, including regions involved in fear excitation (e.g., amygdala, insula) and inhibition (e.g., ventromedial prefrontal cortex). Research has suggested several other small brain regions may play an important role in this process (e.g., hippocampal subfields, bed nucleus of the stria terminalis [BNST], habenula), but, to date, these regions have not been examined …

Behavioral, Physiological, And Molecular Characterization Of Long-Term Administration Of A Novel Estrogen Receptor Beta Agonist In A Mouse Model Of Menopause, Aaron William Fleischer

Theses and Dissertations

The menopausal loss of circulating hormones, including estrogens, is associated with negative symptoms, such as hot flashes, anxiety and depression, cognitive decline, and weight gain. Although estrogenic hormone therapies (HT) prevent many of the negative symptoms related to the menopausal transition, these same therapies are associated with increased health risks, such as the development of breast and ovarian cancers, which is mediated by the activation of the a (ERa), but not b (ERb), estrogen receptor isoform. Furthermore, ERb agonism has previously been shown to reduce preclinical indices of hot flashes, memory decline, anxiety, and depression. As most ERb agonists are …

Neural Correlates Underlying The Interactions Between Anxiety And Cannabis Use In Predicting Motor Response Inhibition, Richard Ward

Theses and Dissertations

The ability to effectively withhold an inappropriate response is a critical feature of cognitive control. Prior research indicates alterations in neural processes required for motor response inhibition in anxious individuals, including those with posttraumatic stress disorder (PTSD), and those who engage in regular cannabis use. However, thus far most research has examined how anxiety-related symptoms and cannabis use influence response inhibition in isolation of one another. The current study examined the interactions between anxious symptomology and recent cannabis use in a sample that recently experienced a traumatic event using functional magnetic resonance imaging (fMRI) during the completion of a Stop-Signal …

How Does Anxiety Affect Cognitive Control? Proactive And Reactive Control Under State Anxiety, Youcai Yang

Theses and Dissertations

Cognitive control is a construct that prioritizes how we process stimuli and information and execute behaviors to flexibly and efficiently adapt to internal goals and external environmental changes. A recent theory, the Dual Mechanism of Control (DMC), distinguishes this phenomenon by two distinct cognitive control operations: proactive control and reactive control (Braver, 2012). Anxiety increases the allocation of attentional and working memory resources to threat-related stimuli, which impairs cognitive performance (Sarason, 1988), but additional work is needed to assess how anxiety impacts these two distinct forms of cognitive control. In this study, I examined how state anxiety affected proactive control, …

Neural Circuitry Underlying The Intrusion Of Task-Irrelevant Threat Into Working Memory In Anxiety, Daniel Stout

Theses and Dissertations

Dispositional anxiety is an important risk factor for the development of anxiety and other psychological disorders. Symptoms commonly expressed by highly anxious individuals include intrusive memories, uncertainty, and worry — all occurring in the absence of immediate threat. This raises the possibility that anxious individuals have difficulty governing threat’s access to working memory, the mental workspace where goal-related information is actively retained for guiding on-going behavior. Using functional magnetic resonance imaging (fMRI) while 81 subjects completed a well-validated working memory task, I show that threat-related and neutral distracters unnecessarily gain access to working memory, as evidenced by increased neural activity …

Neural Plasticity Of Extinction: Relations With Anxiety And Extinction Retention, Emily Louise Belleau

Theses and Dissertations

ABSTRACT

NEURAL PLASTICITY OF EXTINCTION LEARNING: RELATIONS WITH ANXIETY AND EXTINCTION RETENTION

by

Emily L. Belleau

The University of Wisconsin-Milwaukee, 2016

Under the Supervision of Associate Professor Christine Larson

Anxiety is a significant public health problem characterized by substantial psychological, physical, and economic burden. A key feature of anxiety is the inability to regulate fear. Aberrant extinction of conditioned fear is one prominent model of the etiology of anxiety disorders. Previous studies have shown that the neural circuitry underlying anxiety pathology overlaps with that mediating fear extinction learning. Recently, more precise pathways supporting the expression (CMA-aMCC) and inhibition (BLA-vmPFC) of …