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Full-Text Articles in Other Statistics and Probability
Trans-Ancestry Fine Mapping And Molecular Assays Identify Regulatory Variants At The Angptl8 Hdl-C Gwas Locus, Maren E. Cannon, Qing Duan, Ying Wu, Monica Zeynalzadeh, Zheng Xu, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, Mete Civelek, Aldons J. Lusis, Johanna Kuusisto, Francis S. Collins, Michael Boehnke, Hua Tang, Markku Laakso, Yun Li, Karen L. Mohlke
Trans-Ancestry Fine Mapping And Molecular Assays Identify Regulatory Variants At The Angptl8 Hdl-C Gwas Locus, Maren E. Cannon, Qing Duan, Ying Wu, Monica Zeynalzadeh, Zheng Xu, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, Mete Civelek, Aldons J. Lusis, Johanna Kuusisto, Francis S. Collins, Michael Boehnke, Hua Tang, Markku Laakso, Yun Li, Karen L. Mohlke
Department of Statistics: Faculty Publications
Recent genome-wide association studies (GWAS) have identified variants associated with highdensity lipoprotein cholesterol (HDL-C) located in or near the ANGPTL8 gene. Given the extensive sharing of GWAS loci across populations, we hypothesized that at least one shared variant at this locus affects HDL-C. The HDL-C–associated variants are coincident with expression quantitative trait loci for ANGPTL8 and DOCK6 in subcutaneous adipose tissue; however, only ANGPTL8 expression levels are associated with HDL-C levels. We identified a 400-bp promoter region of ANGPTL8 and enhancer regions within 5 kb that contribute to regulating expression in liver and adipose. To identify variants functionally responsible for …
The Change In Differing Leukocyte Populations During Vaccination To Bovine Respiratory Disease And Their Correlations With Lung Scores, Health Records, And Average Daily Gain, R. J. Leach, C. G. Chitko-Mckown, G. L. Bennett, S. A. Jones, Stephen D. Kachman, J. W. Keele, K. A. Leymaster, R. M. Thallman, L. A. Kuehn
The Change In Differing Leukocyte Populations During Vaccination To Bovine Respiratory Disease And Their Correlations With Lung Scores, Health Records, And Average Daily Gain, R. J. Leach, C. G. Chitko-Mckown, G. L. Bennett, S. A. Jones, Stephen D. Kachman, J. W. Keele, K. A. Leymaster, R. M. Thallman, L. A. Kuehn
Department of Statistics: Faculty Publications
Bovine respiratory disease (BRD) is the most economically important disease in U.S. feedlots. Infection can result in morbidity, mortality, and reduced average daily gain. Cheap and reliable genetic methods of prediction and protection from BRD would be highly advantageous to the industry. The immune response may correlate with BRD incidence. Cattle (n = 2,182) were vaccinated against common viral and bacterial pathogens of BRD. Two blood samples were collected, one during booster vaccination and one 21d later, enabling 3 phenotypes for each trait [prebooster (pre), postbooster (post), and delta (post minus pre)]. From the blood samples innate and adaptive responses …
Pregnancy Rate And First-Service Conception Rate In Angus Heifers, J. Minick Bormann, L. R. Totir, Stephen D. Kachman, R. L. Fernando, D. E. Wilson
Pregnancy Rate And First-Service Conception Rate In Angus Heifers, J. Minick Bormann, L. R. Totir, Stephen D. Kachman, R. L. Fernando, D. E. Wilson
Department of Statistics: Faculty Publications
The objective of this project was to determine the genetic control of conception rate, or pregnancy percentage in Angus beef heifers. Producers from 6 herds in 5 states provided 3,144 heifer records that included breeding dates, breeding contemporary groups, service sires, and pregnancy check information. Two hundred fourteen sires of the heifers were represented; with 104 sires having less than 5 progeny, and 14 sires having greater than 50 progeny. These data were combined with performance and pedigree information, including actual and adjusted birth weights, weaning weights, and yearling weights, from the American Angus Association database. Heifer pregnancy rate varied …