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Full-Text Articles in Biological and Chemical Physics
Ecology And Virulence Capabilities Of Vibrios Isolated From The Pristine North Inlet Estuary, Savannah Leigh Klein
Ecology And Virulence Capabilities Of Vibrios Isolated From The Pristine North Inlet Estuary, Savannah Leigh Klein
Theses and Dissertations
Vibrio bacteria are Gram negative, motile organisms that occur naturally in most coastal and estuarine ecosystems. Some vibrios are important human pathogens, including Vibrio parahaemolyticus and Vibrio vulnificus. The CDC estimates that vibrios cause 80,000 cases of disease each year in the United States alone. Most cases are caused by V. parahaemolyticus, which infects humans after the consumption of contaminated raw or undercooked seafood, primarily oysters. V. parahaemolyticus causes mild gastroenteritis that is self-limiting unless the patient is immunocompromised. V. vulnificus has a much lower incidence of disease (100 cases in the USA yr-1); however, this organism causes much more …
Regulation Of Cytoplasmic Dynein By Lis1 And Adenomatous Polyposis Coli, Timothy Joshua Hines
Regulation Of Cytoplasmic Dynein By Lis1 And Adenomatous Polyposis Coli, Timothy Joshua Hines
Theses and Dissertations
Cytoplasmic dynein 1 (dynein) is a microtubule motor that plays a role in mitosis, cell migration, and minus-end directed microtubule-based transport. The lissencephaly protein, Lis1, and its binding partner, Ndel1, are critical regulators of cytoplasmic dynein (Niethammer et al., 2000). In humans, haploinsufficiency of Lis1 leads to lissencephaly, a devastating developmental neurological disorder characterized by severe brain malformation, leading to cognitive and motor defects, and progressively worsening seizures (Dobyns et al., 1993). While Lis1 is known to play a role in regulating dynein-dependent functions such as neuronal migration and mitotic spindle orientation during development, the protein is still highly expressed …