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Biological and Chemical Physics Commons™
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Full-Text Articles in Biological and Chemical Physics
Multifunctional Nanopipette For Single Nanoparticles And Proteins Analysis, Popular Pandey
Multifunctional Nanopipette For Single Nanoparticles And Proteins Analysis, Popular Pandey
FIU Electronic Theses and Dissertations
Complex biological processes occur in the nanoscale (1-100 nm) regime. ‘DNA’ which is just 2 nm in dimension is a fundamental building block of all life. ‘Hemoglobin’, a blood protein that transports oxygen throughout our body is only 5 nm in diameter. Importantly, the structure, composition, and dynamics of these nanoscale entities determine their biological function. A slight alteration in the structure and composition can lead to the malfunction of the protein which is key to various diseases including cancer. Therefore, the single-molecule measurement approach is essential to characterize both the average properties and the rare …
Scanning Ion Conductance Microscopy For Single Cell Imaging And Analysis, Namuna Panday
Scanning Ion Conductance Microscopy For Single Cell Imaging And Analysis, Namuna Panday
FIU Electronic Theses and Dissertations
Most biological experiments are performed on an ensemble of cells under the assumption that all cells are identical. However, recent evidence from single cells studies reveals that this assumption is incorrect. Individual cells within the same generation may differ dramatically, and these differences have important consequences for the health and function of the entire living body. I have used Scanning Ion Conductance Microscopy (SICM) for imaging and analysis of topographical change of single cell membrane, which is difficult to be revealed by optical microscopes. Morphological change in the fixed and live HeLa cell membrane during endocytosis of conjugated polymer nanoparticles …