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Full-Text Articles in Biological and Chemical Physics
Investigations Of Cell-Penetrating And Membrane-Pore Forming Peptides, Rudramani Pokhrel
Investigations Of Cell-Penetrating And Membrane-Pore Forming Peptides, Rudramani Pokhrel
FIU Electronic Theses and Dissertations
Cell-penetrating and membrane-pore forming peptides are a class of membrane-active peptides. They are short sequence peptides having both hydrophilic and lipophilic combinations of amino acids. These peptides can have contrast functional diversity. Peptides encoded by viruses function as viroporins and play a critical role in viral replication, propagation, and pathogenesis. One such peptide is the Ebola virus delta peptide, which forms a pore in the host cell membrane. Another set of pore-forming peptides are antimicrobial Lantibiotic peptides that may be useful for killing antibiotic resistant bacteria by disrupting the bacterial membrane through two different possible mechanisms. Not only can they …
Multifunctional Nanopipette For Single Nanoparticles And Proteins Analysis, Popular Pandey
Multifunctional Nanopipette For Single Nanoparticles And Proteins Analysis, Popular Pandey
FIU Electronic Theses and Dissertations
Complex biological processes occur in the nanoscale (1-100 nm) regime. ‘DNA’ which is just 2 nm in dimension is a fundamental building block of all life. ‘Hemoglobin’, a blood protein that transports oxygen throughout our body is only 5 nm in diameter. Importantly, the structure, composition, and dynamics of these nanoscale entities determine their biological function. A slight alteration in the structure and composition can lead to the malfunction of the protein which is key to various diseases including cancer. Therefore, the single-molecule measurement approach is essential to characterize both the average properties and the rare …