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Biological and Chemical Physics Commons™
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- Biomolecular interactions (1)
- Biophysics (1)
- Carbon nanotube based nanoporous membrane devices (1)
- Conformational changes of protein (1)
- DNA supercoiling (1)
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- DNA topoisomerases (1)
- Drug resistance (1)
- Envelope protein (1)
- Finite element simulations (1)
- Heme proteins (1)
- Label-free methods (1)
- Molecular Dynamics Simulation (1)
- Multidrug transporters (1)
- Omicron (1)
- PfMATE (1)
- Physics (1)
- Quartz nanopipettes (1)
- SARS-CoV-2 (1)
- SPR data fitting (1)
- Surface plasmon resonance (SPR) (1)
Articles 1 - 2 of 2
Full-Text Articles in Biological and Chemical Physics
The Role Of Conformational Changes In Viral And Bacterial Protein Functions, Md Lokman Hossen
The Role Of Conformational Changes In Viral And Bacterial Protein Functions, Md Lokman Hossen
FIU Electronic Theses and Dissertations
Proteins do versatile work in cells. They require a cascade of structural changes to perform different tasks like binding to the other neighboring biomolecules, transporting small chemicals, activating a chemical reaction, etc. The structural conformations of proteins can be critical in changing their working ability. In this dissertation, I investigated the role of conformational changes of viral protein, e.g., spike and envelope protein of SARS-CoV-2, and bacterial protein, e.g., multidrug transporter and toxic extrusion protein- PfMATE from Pyrococcus furiosus. Also, I performed molecular docking-based drug screening targeting the E protein to suggest a set of drugs that can be repurposed …
Multimode Analysis Of Nanoscale Biomolecular Interactions, Purushottam Babu Tiwari
Multimode Analysis Of Nanoscale Biomolecular Interactions, Purushottam Babu Tiwari
FIU Electronic Theses and Dissertations
Biomolecular interactions, including protein-protein, protein-DNA, and protein-ligand interactions, are of special importance in all biological systems. These interactions may occer during the loading of biomolecules to interfaces, the translocation of biomolecules through transmembrane protein pores, and the movement of biomolecules in a crowded intracellular environment. The molecular interaction of a protein with its binding partners is crucial in fundamental biological processes such as electron transfer, intracellular signal transmission and regulation, neuroprotective mechanisms, and regulation of DNA topology. In this dissertation, a customized surface plasmon resonance (SPR) has been optimized and new theoretical and label free experimental methods with related analytical …