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Effect Of Motion On The Adc Quantification Accuracy Of Whole-Body Dwibs, A. Stone, Jacinta Browne, Brian Lennon, James Meaney, Andrew Fagan
Effect Of Motion On The Adc Quantification Accuracy Of Whole-Body Dwibs, A. Stone, Jacinta Browne, Brian Lennon, James Meaney, Andrew Fagan
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Diffusion-weighted whole-body imaging with background body signal subtraction was introduced as a qualitative approach to detecting metastases in the body. A liver-mimicking phantom with embedded tumours that could be moved to replicate respiratory motion was developed to assess its ability to accurately quantify ADC values.
RESULTS:
Mean tumour ADC values were unaltered by the motion; however, a significant (p < 0.05) increase in the spread of ADC values was measured, even for relatively large tumours.
CONCLUSIONS:
These findings may be of significance in cancer therapy monitoring where subtle changes in ADC histograms may reveal changes in tumour heterogeneity.